Bioflavonoids + / -

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" Bioflavonoids as Poisons of Human Topoisomerase II-alpha and II beta

May 24,2007-In their laboratory study, the researchers showed that

bioflavonoids poison topoisomerase II in cultured human cells. This

enzyme plays important roles in many critical DNA processes and

removes knots and tangles from the genome.

24/05/07 In an advance toward understanding the contradictory health

effects of bioflavonoids, scientists in Tennessee are reporting that

these natural components of fruits and vegetables poison a key human

enzyme critical for the normal function of DNA. The research is

scheduled for publication in the May 22 issue of ACS' Biochemistry, a

weekly journal.

Neil Osheroff and i J. Bandele point out that bioflavonoids are

the most abundant natural source of antioxidants in the diet, and

ordinarily are considered quite beneficial in protecting against

heart disease, cancer, and other health problems. Despite the

benefits, bioflavonoids also have toxic effects, with ingestion of

high levels among pregnant women linked to rare forms of infant

leukemia.

In their laboratory study, the researchers showed that bioflavonoids

poison topoisomerase II in cultured human cells. This enzyme plays

important roles in many critical DNA processes and removes knots and

tangles from the genome. The enzyme acts by making a double-stranded

cut in DNA, passing another segment of the double helix through the

break, and reconnecting the broken strands. The study found that

three major classes of bioflavonoids interfere with the enzyme in

cells, leading to DNA damage with potential adverse health effects.

The findings provide important new insights into how flavonoids act,

the researchers say.

" Bioflavonoids as Poisons of Human Topoisomerase II-alpha and II

beta " .

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Rodney.