Re: Polyunsaturated or monounsaturated for heart health..

[Guest guest]

Hi Bill:

That seems supportive of the empirical data from humans on the island

of Crete, posted here a couple of years ago.

A comparatively small percentage of the island's population die from

CVD. But the study found that one of the characteristics of those

that do, is that they consume more olive oil than those that do not.

Rodney.

>

> Poly's may be better Mono's for cardio health...

>

>

> J Lipid Res. 2007 May;48(5):1122-31. Epub 2007 Feb 4.Click here to

> read Links

> Monounsaturated fatty acyl-coenzyme A is predictive of

> atherosclerosis in human apoB-100 transgenic, LDLr-/- mice.

> Bell TA 3rd, MD, Kelley K, Sawyer JK, Rudel LL.

>

> Department of Pathology, Section on Lipid Sciences, Wake Forest

> University School of Medicine, Winston-Salem, NC 27157, USA.

>

> ACAT2, the enzyme responsible for the formation of cholesteryl

> esters incorporated into apolipoprotein B-containing lipoproteins by

> the small intestine and liver, forms predominantly cholesteryl

oleate

> from acyl-CoA and free cholesterol. The accumulation of cholesteryl

> oleate in plasma lipoproteins has been found to be predictive of

> atherosclerosis. Accordingly, a method was developed in which fatty

> acyl-CoA subspecies could be extracted from mouse liver and

> quantified. Analyses were performed on liver tissue from mice fed

one

> of four diets enriched with one particular type of dietary fatty

acid:

> saturated, monounsaturated, n-3 polyunsaturated, or n-6

> polyunsaturated. We found that the hepatic fatty acyl-CoA pools

> reflected the fatty acid composition of the diet fed. The highest

> percentage of fatty acyl-CoAs across all diet groups was in

> monoacyl-CoAs, and values were 36% and 46% for the n-3 and n-6

> polyunsaturated diet groups and 55% and 62% in the saturated and

> monounsaturated diet groups, respectively. The percentage of hepatic

> acyl-CoA as oleoyl-CoA was also highly correlated to liver

cholesteryl

> ester, plasma cholesterol, LDL molecular weight, and atherosclerosis

> extent. These data suggest that replacing monounsaturated with

> polyunsaturated fat can benefit coronary heart disease by reducing

the

> availability of oleoyl-CoA in the substrate pool of hepatic ACAT2,

> thereby reducing cholesteryl oleate secretion and accumulation in

> plasma lipoproteins.

>

> PMID: 17277381

>

>

> i'd like to see the full study if anyone has it.

>

> bill4cr

>

[Guest guest]

I agree.

This study is consistent with the effects of oils in

humans, animals and based on models/formulas that we

have seen in studies posted here many times.

PUFA's tends to lower elevated cholesterols.

EFAs are PUFA's.

Thanks

Jeff