Polyunsaturated or monounsaturated for heart health..

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Poly's may be better Mono's for cardio health...

J Lipid Res. 2007 May;48(5):1122-31. Epub 2007 Feb 4.Click here to

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Monounsaturated fatty acyl-coenzyme A is predictive of

atherosclerosis in human apoB-100 transgenic, LDLr-/- mice.

Bell TA 3rd, MD, Kelley K, Sawyer JK, Rudel LL.

Department of Pathology, Section on Lipid Sciences, Wake Forest

University School of Medicine, Winston-Salem, NC 27157, USA.

ACAT2, the enzyme responsible for the formation of cholesteryl

esters incorporated into apolipoprotein B-containing lipoproteins by

the small intestine and liver, forms predominantly cholesteryl oleate

from acyl-CoA and free cholesterol. The accumulation of cholesteryl

oleate in plasma lipoproteins has been found to be predictive of

atherosclerosis. Accordingly, a method was developed in which fatty

acyl-CoA subspecies could be extracted from mouse liver and

quantified. Analyses were performed on liver tissue from mice fed one

of four diets enriched with one particular type of dietary fatty acid:

saturated, monounsaturated, n-3 polyunsaturated, or n-6

polyunsaturated. We found that the hepatic fatty acyl-CoA pools

reflected the fatty acid composition of the diet fed. The highest

percentage of fatty acyl-CoAs across all diet groups was in

monoacyl-CoAs, and values were 36% and 46% for the n-3 and n-6

polyunsaturated diet groups and 55% and 62% in the saturated and

monounsaturated diet groups, respectively. The percentage of hepatic

acyl-CoA as oleoyl-CoA was also highly correlated to liver cholesteryl

ester, plasma cholesterol, LDL molecular weight, and atherosclerosis

extent. These data suggest that replacing monounsaturated with

polyunsaturated fat can benefit coronary heart disease by reducing the

availability of oleoyl-CoA in the substrate pool of hepatic ACAT2,

thereby reducing cholesteryl oleate secretion and accumulation in

plasma lipoproteins.

PMID: 17277381

i'd like to see the full study if anyone has it.

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