Re: More on Protein Restriction

[Guest guest]

I haven't looked at this in depth, but isn't it possible that

increased methionine, without adequate methylation co-factors would

simply raise homocysteine and be a risk factor in this respect?

Thoughts?

--- In , " Rodney " <perspect1111@...>

wrote:

>

> (Something weird happening to the formatting here for some

>

reason)

>

> Hi

>

folks:

>

> I don't think this one has been previously posted. It is dated

> April

>

2007.

>

> 1: J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):352-

>

60.

>

>

Links

>

> Dietary protein restriction decreases oxidative protein damage,

> peroxidizability index, and mitochondrial complex I content in rat

>

liver.

>

> Ayala V, Naudí A, Sanz A, Caro P, Portero-Otin M, Barja G, Pamplona

> R.

>

R.

>

> Department of Basic Medical Sciences, Faculty of Medicine,

University

> of Lleida, Spain.

>

> " Caloric restriction (CR) decreases oxidative damage, which

> contributes to the slowing of aging rate. It is not known if such

> decreases are due to calories themselves or specific dietary

> components. In this work, the ingestion of proteins of Wistar rats

> was decreased by 40% below that of controls. After 7 weeks, the

liver

> of the protein-restricted (PR) animals showed decreases in

oxidative

> protein damage, degree of membrane unsaturation, and mitochondrial

> complex I content. The results and previous information suggest

that

> the decrease in the rate of aging induced by PR can be due in part

to

> decreases in mitochondrial reactive oxygen species production and

DNA

> and protein oxidative modification, increases in fatty acid

> components more resistant to oxidative damage, and decreased

> expression of complex I, analogously to what occurs during CR.

Recent

> studies suggest that those benefits of PR could be caused, in turn,

> by the lowered methionine intake of that dietary manipulation. "

>

> PMID:

>

17452727

>

> Rodney.

>