Vitamin D and Premenopausal Breast Cancer

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Vitamin D Intake May Reduce the Risk of Premenopausal Breast Cancer

Keywords: BREAST CANCER, PREMENOPAUSAL WOMEN - Vitamin D, Calcium

Reference: " Dietary vitamin D and calcium intake and premenopausal

breast cancer risk in a German case-control study, " Abbas S, Linseisen

J, Chang-Claude J, Nutr Cancer, 2007; 59(1): 54-61. (Address: Division

of Cancer Epidemiology, German Cancer Research Center, Heidelberg,

Germany).

Summary: In a population-based case-control study in Germany

involving 278 premenopausal women with breast cancer and 666

age-matched controls, vitamin D intake was found to be inversely

associated with risk of breast cancer. Dietary intakes were assessed

via food frequency questionnaires completed by participants. Subjects

with the highest intake of vitamin D (> or = 5 microg/day) has a 0.50

odds ratio of breast cancer, compared to subjects with the lowest

intake (< 2 microg/day). Subjects with the highest intake of calcium

(> or = 1,300 mg/day) had a 0.73 odds ratio of breast cancer, compared

to subjects with the lowest intake (< 700 mg/day) - this was not

considered a significant association. No significant interaction

effect was found between vitamin D and calcium. The authors conclude,

" Our data support a protective effect of dietary vitamin D on

premenopausal breast cancer risk independent of dietary calcium intake. "