More on Protein Restriction

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Hi

folks:

I don't think this one has been previously posted. It is dated

April

2007.

1: J Gerontol A Biol Sci Med Sci. 2007 Apr;62(4):352-

60.

Links

Dietary protein restriction decreases oxidative protein damage,

peroxidizability index, and mitochondrial complex I content in rat

liver.

Ayala V, Naudí A, Sanz A, Caro P, Portero-Otin M, Barja G, Pamplona

R.

R.

Department of Basic Medical Sciences, Faculty of Medicine, University

of Lleida, Spain.

" Caloric restriction (CR) decreases oxidative damage, which

contributes to the slowing of aging rate. It is not known if such

decreases are due to calories themselves or specific dietary

components. In this work, the ingestion of proteins of Wistar rats

was decreased by 40% below that of controls. After 7 weeks, the liver

of the protein-restricted (PR) animals showed decreases in oxidative

protein damage, degree of membrane unsaturation, and mitochondrial

complex I content. The results and previous information suggest that

the decrease in the rate of aging induced by PR can be due in part to

decreases in mitochondrial reactive oxygen species production and DNA

and protein oxidative modification, increases in fatty acid

components more resistant to oxidative damage, and decreased

expression of complex I, analogously to what occurs during CR. Recent

studies suggest that those benefits of PR could be caused, in turn,

by the lowered methionine intake of that dietary manipulation. "

PMID:

17452727

Rodney.