Re: Man-made version of resveratrol 1,000x more potent

[Guest guest]

Here's another article regarding this Sirtis pharmaceuticals and

Harvard medical school study with man-made " super resveratrol. " They

claim SIRT1 activator drugs could be available as early as 2012 or 2013.

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link:

http://www.diabetesincontrol.com/results.php?storyarticle=5326

full text:

Red Wine A Possible Cure for Diabetes?

Millions of people with adult diabetes could one day be treated with a

drug based on the healthy ingredient of red wine which could even help

prevent other diseases linked with old age.

The new class of drugs, which will be tested on patients next year in

Europe or the US mimics the effects of a reduced-calorie diet, which

is known to extend the lifespan of a wide range of creatures, from

worms to mice and monkeys.

They work in the same way as resveratrol, the chemical in wine and

grapes thought to deliver some of the proposed health benefits and

explain the " French paradox, " referring to how the French suffer

relatively low incidence of coronary heart disease, despite having a

diet relatively rich in saturated fats.

The problem with red wine is that earlier animal research suggested

that around 1000 glasses would have to be consumed each day to take

enough resveratrol to reduce the impact of a high fat diet, increase

stamina two fold and significantly extend lifespan.

In a new report from researchers led by Christoph Westphal of the

company Sirtris Pharmaceuticals, Cambridge, and Sinclair of

Harvard Medical School they report that, new compounds have been

developed that are roughly 1,000 times more potent than resveratrol

and are also 1,000 times better at staving off the development of type

2 diabetes,

" The novel drug candidates we have identified can potentially unlock a

whole new approach to treating Type 2 Diabetes, " stated Dr Jill Milne,

lead author of the study.

Type 2 diabetes occurs when the body becomes insensitive to the

effects of the hormone insulin and it seems that the new drugs can

boost insulin sensitivity substantially.

The new drug candidates work by activating a protein called SIRT1,

which influences the ageing process and functions to ensure that the

body remains receptive to the activity of insulin.

The compounds potentially offer an important new avenue for developing

treatments to tackle diseases linked to ageing and poor diet. " The new

drug candidates represent a significant milestone because they are the

first molecules that have been designed to act on genes that control

the ageing process.

" For this reason, we feel they have considerable potential to treat

diseases of ageing such as Type 2 Diabetes, " said Dr Westphal.

" The breakthrough in potency we have achieved means that we can obtain

the health benefits of resveratrol with a considerably lower dose. "

" If all goes well, SIRT1 activator drugs could be available on the

market as early as 2012 or 2013. "

Nature. Nov 28, 2007

>

> Compound made by Sirtris Pharmaceuticals is a souped up version of

> resveratrol that activates the SIRT1 gene in mice as resveratrol does,

> but is 1,000 times more potent.

>

>

> link:

>

>

http://diabetes.webmd.com/news/20071129/wine-compound-spurs-diabetes-research

>

>

> full text:

>

> Wine Compound Spurs Diabetes Research