Re: Longevity pill

[Guest guest]

Hi Francesca:

It looks like this article cover the same subject matter:

http://www.technologyreview.com/Biotech/19776/

Rodney.

>

> Heard a piece on NPR radio just now that a longevity pill is in the

works.

> The pill is supposedly 1000X more potent than resveratrol.and has

reversed

> diabetes in rats. They are hoping it will reverse all diseases of

aging.

>

> Published in the Journal NATURE if anyone can access it. Also

studies have

> shown that resveratrol is NOT as potent when taken alone as when

taken with

> grapes. Once again nature triumphs over man-made supplements.

>

[Guest guest]

I always take my Longevinex pills with a glass of red wine, having

suspected as much.

;-)

Maco

At 07:55 AM 11/29/2007, you wrote:

Heard a piece on NPR radio just

now that a longevity pill is in the works. The pill is supposedly 1000X

more potent than resveratrol.and has reversed diabetes in rats.

They are hoping it will reverse all diseases of aging.

Published in the Journal NATURE if anyone can access it. Also

studies have shown that resveratrol is NOT as potent when taken alone as

when taken with grapes. Once again nature triumphs over man-made

supplements.

[Guest guest]

Ya, but- ya gotta eat a lot of grapes and/or drink massive quantities of wine toeven approach resveratrol/and or sirtuin activator levels similar to those given in

the studies by Sinclair and others studying the effects of these compounds. Mixing

with wine and grapes is, no doubt, helpful, but wine and grapes alone ain't gonna get ya significantlife extension, if, indeed, it can be achieved at all in humans by sirtuin activators.

On Nov 29, 2007 11:24 AM, Maco <mstewart@...> wrote:

I always take my Longevinex pills with a glass of red wine, having

suspected as much.

;-)

Maco

At 07:55 AM 11/29/2007, you wrote:

Heard a piece on NPR radio just

now that a longevity pill is in the works. The pill is supposedly 1000X

more potent than resveratrol.and has reversed diabetes in rats.

They are hoping it will reverse all diseases of aging.

Published in the Journal NATURE if anyone can access it. Also

studies have shown that resveratrol is NOT as potent when taken alone as

when taken with grapes. Once again nature triumphs over man-made

supplements.

[Guest guest]

Maco: you would need something like 1000 glasses of red wine to get the effect that rodents got! I say this even though I too drink some wine (mindful of the study that those who drank wine lived longer than those who didn’t) and I’m taking resveratrol. But I’m not sure it’s doing anything but lightening my pocketbook. In fact now I KNOW it’s not doing anything.

I look forward to a real longevity pill (Lord only knows what it will cost – as the song goes “If living were a thing that money could buy – you know the rich would live and the poor would die”) as well as eating hot fudge sundaes again!

And what are we going to do with all those people who don’t die.?...the earth is plenty overpopulated already.

From: Maco <mstewart@...>

Reply-< >

Date: Thu, 29 Nov 2007 09:24:08 -0700

< >

Subject: Re: [ ] Longevity pill

I always take my Longevinex pills with a glass of red wine, having suspected as much.

;-)

Maco

At 07:55 AM 11/29/2007, you wrote:

Heard a piece on NPR radio just now that a longevity pill is in the works. The pill is supposedly 1000X more potent than resveratrol.and has reversed diabetes in rats. They are hoping it will reverse all diseases of aging.

Published in the Journal NATURE if anyone can access it. Also studies have shown that resveratrol is NOT as potent when taken alone as when taken with grapes. Once again nature triumphs over man-made supplements.

[Guest guest]

At 09:31 AM 11/29/2007, you wrote:

Ya, but- ya gotta eat a lot

of grapes and/or drink massive quantities of wine to

even approach resveratrol/and or sirtuin activator levels similar to

those given in

the studies by Sinclair and others studying the effects of these

compounds. Mixing

with wine and grapes is, no doubt, helpful, but wine and grapes alone

ain't gonna get ya significant

life extension, if, indeed, it can be achieved at all in humans by

sirtuin activators.

We'll see. The conjugation likely provides an abiding low-level store of

ongoing free resveratrol infusion in the body, and that they use much

higher doses in mice doesn't necessarily mean it's ineffectual in

humans.

In any case, the glass of red wine stays, so except for the

buck-something I'm out for the two pills a day, the benefits remain

undetermined while the cost is acceptable, to me.

Maco

On Nov 29, 2007 11:24 AM, Maco

<mstewart@...>

wrote:

I always take my Longevinex pills with a glass of red wine, having

suspected as much.

;-)

Maco

At 07:55 AM 11/29/2007, you wrote:

Heard a piece on NPR radio just now that a longevity pill is in the

works. The pill is supposedly 1000X more potent than resveratrol.and has

reversed diabetes in rats. They are hoping it will reverse all

diseases of aging.

Published in the Journal NATURE if anyone can access it. Also

studies have shown that resveratrol is NOT as potent when taken alone as

when taken with grapes. Once again nature triumphs over man-made

supplements.

[Guest guest]

Hi All, The article is pdf-availed, and the abstract and citation are: Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes p712Jill C. Milne, Philip D. Lambert, Simon Schenk, P. Carney, J. , J. Gagne, Lei Jin, Olivier Boss, B. Perni, Chi B. Vu, E. Bemis, Xie, S. Disch, Pui Yee Ng, ph J. Nunes, Amy V. Lynch, Hongying Yang, Heidi Galonek, e Israelian, Choy, Andre Iffland, Siva Lavu, Oliver Medvedik, A. Sinclair, Jerrold M. Olefsky, R. Jirousek, J. Elliott & Christoph H. WestphalNature 450, 712-716 (29 November 2007); Received 3 August 2007 Calorie restriction extends lifespan and produces a metabolic profile desirable for treating diseases of ageing such as type 2 diabetes1, 2. SIRT1, an NAD+-dependent deacetylase, is a principal modulator of

pathways downstream of calorie restriction that produce beneficial effects on glucose homeostasis and insulin sensitivity3, 4, 5, 6, 7, 8, 9. Resveratrol, a polyphenolic SIRT1 activator, mimics the anti-ageing effects of calorie restriction in lower organisms and in mice fed a high-fat diet ameliorates insulin resistance, increases mitochondrial content, and prolongs survival10, 11, 12, 13, 14. Here we describe the identification and characterization of small molecule activators of SIRT1 that are structurally unrelated to, and 1,000-fold more potent than, resveratrol. These compounds bind to the SIRT1 enzyme–peptide substrate complex at an allosteric site amino-terminal to the catalytic domain and lower the is constant for acetylated substrates. In diet-induced obese and genetically obese mice, these compounds improve insulin sensitivity, lower plasma glucose, and increase mitochondrial capacity. In Zucker fa/fa rats, hyperinsulinaemic-euglycaemic clamp studies

demonstrate that SIRT1 activators improve whole-body glucose homeostasis and insulin sensitivity in adipose tissue, skeletal muscle and liver. Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes.Francesca Skelton <fskelton@...> wrote: Heard a piece on NPR radio just now that a longevity pill is in the works. The pill is supposedly 1000X more potent than resveratrol.and has reversed

diabetes in rats. They are hoping it will reverse all diseases of aging.Published in the Journal NATURE if anyone can access it. Also studies have shown that resveratrol is NOT as potent when taken alone as when taken with grapes. Once again nature triumphs over man-made supplements.

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[Guest guest]

Whoops! Correction/amendment:On Nov 29, 2007 6:14 PM, Dowling <christopher.a.dowling@...

> wrote:

Can anyone cite the studies purported to show resveratrol is not as potent alone

as when taken with grapes.

..