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DR House On Selenium

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wrote:

> My recollection is that too much selenium intake has visible symptoms

> like

> discolored finger nails and toenails.

There is also some similarities to radiation poisoning, at least it was

in the House episode I saw. I think that eating a Brazil nut every day

would pose no risk and provide plenty of the mineral. (Although the guy

in the House episode eat a huge amount on a trip to Brazil)

Positive Dennis

>

> JR

> On Feb 28, 2008, at 9:35 AM, Diane Walter wrote:

>

>> Walford discusses selenium in BYT20YD. This article discusses how

>> there is a fine line between too much and too little. Does any

>> test measure blood levels of selenium? None of mine mention it.

>>

>> Diane

>>

>> http://www.nlm.nih.gov/medlineplus/news/fullstory_61552.html

>> <http://www.nlm.nih.gov/medlineplus/news/fullstory_61552.html>

>>

>> Moderate Selenium Levels Tied to Longer Life

>>

>> NEW YORK (Reuters Health) - When it comes to the effects of selenium

>> on health and longevity, you may be able to get too much of a good

>> thing. While moderate levels of the mineral are associated with

>> longevity, once selenium levels climb past a certain mark, the odds of

>> dying from any cause, or from cancer specifically, begin to tip

>> upward, a new study suggests.

>>

>> The study, of nearly 14,000 U.S. adults, found that higher blood

>> levels of selenium were linked to a lower risk of death over 12 years,

>> at which point the risk appears to increase.

>>

>> The findings, published in the Archives of Internal Medicine, support

>> earlier studies linking selenium to lower risks of prostate, lung and

>> colon cancers. But the study also " raises the concern that high-normal

>> levels of selenium may be associated with an increased risk of

>> mortality, " write the researchers, led by Dr. Joachim Bleys of s

>> Hopkins University School of Public Health in Baltimore.

>>

>> Selenium is a mineral that people require in small amounts; food

>> sources include grains, certain nuts and some meats and seafood, such

>> as beef and tuna.

>>

>> The body incorporates selenium into proteins called selenoproteins,

>> which act as antioxidant enzymes; antioxidants, in turn, help

>> neutralize cell-damaging substances called free radicals. Some studies

>> have linked higher selenium levels to lower risks of certain cancers

>> and heart disease.

>>

>> However, much of the research has been done in countries where

>> people's selenium levels are often fairly low.

>>

>> Most Americans, by contrast, get more than the recommended amount of

>> selenium. While the recommended dietary allowance (RDA) is only 55

>> micrograms per day, the typical intake in the U.S. ranges from 60 to

>> 220 micrograms daily.

>>

>> For their study, Bleys and his colleagues used data for 13,887 U.S.

>> adults who took part in a government health and nutrition study. They

>> found that as the participants' blood levels of selenium increased,

>> their odds of dying during the 12-year study period declined -- but

>> only up to a point.

>>

>> Once blood levels of selenium surpassed 130 ng/mL, the benefits

>> stopped accruing; and once they passed 150 ng/mL, the odds of dying

>> from any cause, or from cancer in particular, began to creep back up.

>>

>> The findings caution against consuming too much selenium, according to

>> the researchers.

>>

>> " Most people in the U.S. obtain adequate selenium from their diet, "

>> Bleys told Reuters Health, noting that outright selenium deficiency is

>> rare.

>>

>> Given this, and the potential for adverse effects from high selenium

>> levels, Bleys said there is " no rationale " for recommending selenium

>> supplements to the general public.

>>

>> It is not clear why high-normal selenium levels were tied to an

>> increased death risk. But in theory, Bleys explained, excess selenium

>> that is not incorporated into selenoproteins may actually generate

>> free radicals rather than fight them.

>>

>> SOURCE: Archives of Internal Medicine, February 25, 2008.

>>

>

>

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