CR in Pregnancy

[Guest guest]

Hi folks:

" Our laboratory and others have demonstrated that low birth weight

rats, induced by maternal food restriction or uterine artery

ligation, paradoxically develop adult obesity with glucose

intolerance and hypertension " .

Source of quotation:

" Gestational programming of offspring obesity: a potential

contributor to Alzheimer's disease. "

Ross MG, Desai M, Khorram O, McKnight RA, Lane RH, Torday J.

Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center,

Torrance, California 90502, USA. mikeross@...

" Obesity and its related diseases are the leading cause of death in

western society, with associated risks of hypertension, coronary

heart disease, stroke, diabetes, and breast, prostate and colon

cancer. Recent epidemiologic data indicate an increased risk of

Alzheimer's disease in association with adult obesity. There is now

convincing evidence that, in both human and animal models, the in

utero environment may impact on fetal developmental processes,

altering offspring homeostatic regulatory mechanisms. " Gestational

programming " may result in altered cell number, organ structure,

hormonal set points or gene expression, with effects being permanent

or expressed only at select offspring ages (e.g., newborn, adult).

Our laboratory and others have demonstrated that low birth weight

rats, induced by maternal food restriction or uterine artery

ligation, paradoxically develop adult obesity with glucose

intolerance and hypertension. Recent studies indicate alterations in

peripheral (hepatic) and central (hippocampus) IGF-1 gene expression

and epigenetic regulation among these offspring. These findings

suggest that potential risk factors for the development of

Alzheimer's disease may be present as early as newborn life. "

PMID: 17430249

Perhaps this needs to go in the files, as a warning regarding CR

during pregnancy?

Rodney.