Guest guest Posted July 5, 2007 Report Share Posted July 5, 2007 http://www.brainatlas.com/aba/2007/070705/full/nrn2177.shtml This article begins as follows: Research Highlights A long and lean lifeNature Reviews Neuroscience 8, 7 (July 2007) | doi:10.1038/nrn2177 Dietary restriction extends lifespan in many species, but how it does so is unknown. Now, Bishop and Guarente have revealed a molecular process by which diet restriction, through activation of the transcription factor SKN-1 in two sensory neurons, can influence mitochondrial activity in peripheral tissues and thereby possibly delay the ageing process in Caenorhabditis elegans. The authors provided C. elegans with a diet containing different concentrations of bacteria (their usual food) and confirmed that the worms' lifespan increased as the concentration of bacteria decreased. Searching for the underlying molecular mechanism, they focused on the transcription factor SKN-1. SKN-1 has a role in embryogenesis, but is also implicated in the regulation of oxidative stress, a process that has been linked to ageing. Maco Quote Link to comment Share on other sites More sharing options...
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