Re: Food Intake and Hip Fracture

[Guest guest]

Hi folks:

And this one seems to be saying much the same.

" A high ratio of dietary animal to vegetable protein increases the

rate of bone loss and the risk of fracture in postmenopausal women. "

Study of Osteoporotic Fractures Research Group.

Sellmeyer DE, Stone KL, Sebastian A, Cummings SR.

Division of Endocrinology, the General Clinical Research Center, and

the Department of Epidemiology and Biostatistics, University of

California, San Francisco, USA. dsellmeyer@...

" BACKGROUND: Different sources of dietary protein may have different

effects on bone metabolism. Animal foods provide predominantly acid

precursors, whereas protein in vegetable foods is accompanied by base

precursors not found in animal foods. Imbalance between dietary acid

and base precursors leads to a chronic net dietary acid load that may

have adverse consequences on bone. OBJECTIVE: We wanted to test the

hypothesis that a high dietary ratio of animal to vegetable foods,

quantified by protein content, increases bone loss and the risk of

fracture. DESIGN: This was a prospective cohort study with a mean (+/-

SD) of 7.0+/-1.5 y of follow-up of 1035 community-dwelling white

women aged >65 y. Protein intake was measured by using a food-

frequency questionnaire and bone mineral density was measured by dual-

energy X-ray absorptiometry. RESULTS: Bone mineral density was not

significantly associated with the ratio of animal to vegetable

protein intake. Women with a high ratio had a higher rate of bone

loss at the femoral neck than did those with a low ratio (P = 0.02)

and a greater risk of hip fracture (relative risk = 3.7, P = 0.04).

These associations were unaffected by adjustment for age, weight,

estrogen use, tobacco use, exercise, total calcium intake, and total

protein intake. CONCLUSIONS: Elderly women with a high dietary ratio

of animal to vegetable protein intake have more rapid femoral neck

bone loss and a greater risk of hip fracture than do those with a low

ratio. This suggests that an increase in vegetable protein intake and

a decrease in animal protein intake may decrease bone loss and the

risk of hip fracture. This possibility should be confirmed in other

prospective studies and tested in a randomized trial. "

PMID: 11124760

Rodney.

--- In , " Rodney " <perspect1111@...>

wrote:

>

> Hi folks:

>

> Vegans will like this one:

>

> " Worldwide incidence of hip fracture in elderly women: relation to

> consumption of animal and vegetable foods. "

>

> Frassetto LA, Todd KM, RC, Sebastian A.

>

> Department of Medicine and General Clinical Research Center,

> University of California, San Francisco 94143, USA.

>

> " BACKGROUND: Hip fracture, a major health problem in elderly

persons,

> varies in incidence among the populations of different countries

and

> is directly related to animal protein intake, a finding that

suggests

> that bone integrity is compromised by endogenous acid production

> consequent to the metabolism of animal proteins. If that is so,

> vegetable foods might provide a countervailing effect, because they

> are a rich source of base (bicarbonate) in the form of

metabolizable

> organic anions, which can neutralize protein-derived acid and

supply

> substrate (carbonate) for bone formation. METHODS: We analyzed

> reported hip fracture incidence (HFI) data among countries (N = 33)

> in women aged 50 years and older, in relation to corresponding

> country-specific data on per capita consumption of vegetable and

> animal foods as reported by the United Nations Food and Agriculture

> Organization. RESULTS: HFI varied directly with total (r = +.67, p

> < .001) and animal (r = +.82, p < .001) protein intake and

inversely

> with vegetable protein intake (r = .37, p < .04). The countries in

> the lowest tertile of HFI (n = 11) had the lowest animal protein

> consumption, and invariably, vegetable protein (VP) consumption

> exceeded the country's corresponding intake of animal protein (AP):

> VP/AP > 1.0. By contrast, among the countries in the highest

tertile

> of HFI, animal protein intake exceeded vegetable protein intake in

> nearly every case (10 of 11 countries). Among all countries, HFI

> correlated inversely and exponentially with the ratio of

> vegetable/animal protein intake (r = -.84, p < .001) and accounted

> for 70% of the total variation in HFI. Adjusted for total protein

> intake, vegetable food consumption was an independent negative

> predictor of HFI. All findings were similar for the subset of 23

> countries whose populations are predominantly Caucasian.

CONCLUSION:

> The findings suggest that the critical determinant of hip fracture

> risk in relation to the acid-base effects of diet is the net load

of

> acid in the diet, when the intake of both acid and base precursors

is

> considered. Moderation of animal food consumption and an increased

> ratio of vegetable/animal food consumption may confer a protective

> effect. "

>

> PMID: 11034231

>

> Rodney.

>