Fasting, mitochondrial NAD levels, cell survival and longevity

[Guest guest]

Last week the Sinclair's lab at Harvard published a paper in Cell in

which a new link between fasting and mitochondrial health is proposed.

According to their report fasting promotes increased expression of the

enzyme Nampt which is critical for NAD+ biosynthesis. Cells in which

the enzyme is increased (either by fasting or by over-expression

achived by genetically engeneering mice) show enhanced resistance to

sress induced by various chemical agents.

http://www.cell.com/content/article/abstract?uid=PIIS0092867407009737

http://www.technologyreview.com/Biotech/19413/page1/

Andre