IGF-1

[Guest guest]

Donna, will you tell us from which company you

purchased your IGF-1? Thanks, Joy

__________________________________________________

[Guest guest]

I got mine from NOW Foods, but I understand that they all get it from the same

people in New Zealand. So, no matter who you buy it from, it is all the same

product.

Donna

-----Original Message-----

Donna, will you tell us from which company you

purchased your IGF-1? Thanks, Joy

[Guest guest]

Hi Jim and others. I got this question from someone privately and wonder if

someone can help me answer this. I just read a study that said the opposite,

but unfortunately I didn't copy and save it so I have no reference.

Does anyone have any info?

Thanks,

Donna

-----Original Message-----

Hi Donna,

Was researching IGF-1 a bit. Sounds too good to be true and it could help

my mom. Mercola's negative stuff is below. Am interested in any comments

you may have.

http://www.mercola.com/2000/oct/29/igf1_cancer.htm

Cancer and IGF-1: Another Reason to Avoid Milk

In a recent editorial in the British Medical Journal, several experts from

the University of Bristol in England write about the substantial and still

growing body of evidence implicating insulin-like growth factor-I (IGF-1) in

cancer.

They note that the role of IGF-1 in promoting cancer has been investigated

for many years, but recently the quality and quantity of evidence has

increased

They note that several prospective studies have used stored blood collected

up to 14 years before the onset of cancer have shown associations between

IGF-1 and prostate cancer, premenopausal breast cancer, and colon cancer.

According to the editorial, " The risk of cancer is higher among people with

raised concentrations of insulin-like growth factor-I " .

In addition, " it is lower among those with high concentrations of

insulin-like growth factor binding protein-3 (the main binding protein). "

Research suggests that the observed relation between cancer and IGF-1 is not

due to the release of the growth factor by the cancer itself.

" The effects are sizeable and stronger than the effects seen in relation to

most previously reported risk factors " they state.

In addition to the increasing direct epidemiological evidence, there is a

significant amount of circumstantial evidence.

Acromegaly, in which high concentrations of growth hormone stimulate

production of high concentrations of IGF-1, has been associated with an

increased risk of colorectal cancer and breast cancer in some studies and

less consistently with prostate, thyroid, and hematological malignancies.

In many studies anthropometric markers of the activity of insulin-like

growth factor-I, such as height and leg length, are associated with cancer

incidence, particularly with the cancers for which risk increases with

rising concentrations of insulin-like growth factor-I.

In animals, calorie restriction reduces the risk of cancer primarily by

reducing the circulating concentrations of insulin-like growth factor-I " the

editorial notes.

Some of the potential mechanisms of the way in which IGF-1 increases cancer

risk are as follows:

IGF-1 could be a surrogate for the activity of sex steroid hormones, which

in turn influence the risk of cancer.

IGF-1 may increase cell turnover and the susceptibility of cells to

malignant transformation both directly and by modulating the effects of sex

steroids.

IGF-1 might increase the risk of cancer by preventing the programmed death

of cells that have been transformed, thus interrupting an important process,

which retards the development of cancer.

" Given the increasing evidence of the risk of cancer, caution should be

exercised in the exogenous use of either insulin-like growth factor-I or

substances that increase concentrations of it, " they state.

British Medical Journal October 7, 2000;321:847-848

DR. MERCOLA'S COMMENT: Many may not realize that when you drink milk you are

consuming IGF-1, along with many other growth factors. Milk from cows

treated with synthetic growth hormones such as rBGH have especially high

levels of IGF-1. This is one of the many reasons why I advise avoiding milk.

You can click on the links below for the others.

It is also interesting to note that the growth hormone that is so strongly

promoted by many anti-aging clinicians may in fact have adverse effects by

raising insulin-like growth factor-I. It is probably best for most to avoid

the use of growth hormone and rely on more proven and less risky

interventions, like a good diet which reduces insulin levels and also weight

training which can increase growth hormone.

[Guest guest]

Donna,

The answer is simple: cancer is caused by a lack of oxygen, not IGF-1,

which is constantly created in a healthy human when their GH hits their

liver. Are these researchers suggesting that a healthy body is designed

to create cancers that will destroy it?

Does IGF-1 promotes cancer because it is a demon growth factor, or is

the truth closer to the fact that any growth factor can be utilized by a

cancer if the subject has allowed one to exist. But, those same growth

factors, with an oxygenated body that is not fermenting to stay alive,

will heal the damage done by the cancer.

I keep reminding folks in context that hypoxia causes cancer, not any of

the other mumbo-jumbo quack research comes up with! It took me a while

for it to sink in too!

jim

Donna wrote:

>

> Hi Jim and others. I got this question from someone privately and wonder if

someone can help me answer this. I just read a study that said the opposite,

but unfortunately I didn't copy and save it so I have no reference.

>

> Does anyone have any info?

>

> Thanks,

> Donna

-----

The TRUTH in 11 words:

Inside every older person is a younger person wondering what happened!

-- anon

jlambert@... http://www.entrance.to/madscience

http://www.entrance.to/poetry

[Guest guest]

Dear Jim,

That is correct.

And, in addition, the T-cells and macrophages release enzyme growth hormone

when they come across a damaged area, which they recognize because of its

increased acidity. Since cancer is fermenting sugar and throwing off waste

lactic acid, it is always surrounding by lots of acidity. Therefore, if

there was no IGF-1 in the whole body, it wouldn't make any difference,

because the T-cells and macrophages will do their thing, and the cancer will

be stimulated to grow.

I think that store-bought cow's milk - homogenized & pasteurized - is not a

good food. But, I don't think that the IGF-1 is a major factor in avoiding

it. There are lots worse problems with the product than that. How about

undigestible blobs of fat caused by homogenization? How about no enzymes

alive because of pasteurization?

Best of Health!

Dr. Saul Pressman, DCh, LOH

Re: Fw: IGF-1

> Donna,

>

> The answer is simple: cancer is caused by a lack of oxygen, not IGF-1,

> which is constantly created in a healthy human when their GH hits their

> liver. Are these researchers suggesting that a healthy body is designed

> to create cancers that will destroy it?

>

> Does IGF-1 promotes cancer because it is a demon growth factor, or is

> the truth closer to the fact that any growth factor can be utilized by a

> cancer if the subject has allowed one to exist. But, those same growth

> factors, with an oxygenated body that is not fermenting to stay alive,

> will heal the damage done by the cancer.

>

> I keep reminding folks in context that hypoxia causes cancer, not any of

> the other mumbo-jumbo quack research comes up with! It took me a while

> for it to sink in too!

>

> jim

>

> Donna wrote:

> >

> > Hi Jim and others. I got this question from someone privately and

wonder if someone can help me answer this. I just read a study that said

the opposite, but unfortunately I didn't copy and save it so I have no

reference.

> >

> > Does anyone have any info?

> >

> > Thanks,

> > Donna

> -----

> The TRUTH in 11 words:

> Inside every older person is a younger person wondering what happened!

> -- anon

>

> jlambert@... http://www.entrance.to/madscience

> http://www.entrance.to/poetry

>

>

[Guest guest]

Hi Martha and All,

Martha, could you tell us about your usage

of Hgh. I heard

that it was very expensive. Why are you taking it? Is it helpful and

how?

Thanks

Mike

[Guest guest]

> Forgive me for my ignorance, but is IGF-1 insulin-like growth

factor

> 1 released from the liver in response to growth hormone or

> carbohydrate consumption?

>

> Webster, CFC

> Kingston, Ontario

>

>

> *Don't forget to sign all letters with full name and city of

> residence if you wish them to be published!

To the best of my recollection it is the response to Growth Hormone.

Mike

Boston, MA

[Guest guest]

> Forgive me for my ignorance, but is IGF-1 insulin-like growth

factor

> 1 released from the liver in response to growth hormone or

> carbohydrate consumption?

>

> Webster, CFC

> Kingston, Ontario

>

>

> *Don't forget to sign all letters with full name and city of

> residence if you wish them to be published!

To the best of my recollection it is the response to Growth Hormone.

Mike

Boston, MA

[Guest guest]

Hi folks:

IGF-1 is an interesting biomarker. I was thinking of getting mine

measured recently but didn't because I haven't seen data for

reference ranges, which I believe vary by age. Lower IGF-1 seems to

be better. But also it drops with age. So how could one tell

whether a low number reflected being super healthy, or rather just

plain old?! If anyone knows of reference ranges and comparative

numbers for people on CRON it would be interesting to see them.

ITMT (in the meantime!) here is the abstract of a paper which

discusses it:

" A low-fat, whole-food vegan diet, as well as other strategies that

down-regulate IGF-I activity, may slow the human aging process. "

McCarty MF.

Pantox Laboratories, San Diego, California 92109, USA.

" A considerable amount of evidence is consistent with the

proposition that systemic IGF-I activity acts as pacesetter in the

aging process. A reduction in IGF-I activity is the common

characteristic of rodents whose maximal lifespan has been increased

by a wide range of genetic or dietary measures, including caloric

restriction. The lifespans of breeds of dogs and strains of rats

tend to be inversely proportional to their mature weight and IGF-I

levels. The link between IGF-I and aging appears to be

evolutionarily conserved; in worms and flies, lifespan is increased

by reduction-of-function mutations in signaling intermediates

homologous to those which mediate insulin/IGF-I activity in mammals.

The fact that an increase in IGF-I activity plays a key role in the

induction of sexual maturity, is consistent with a broader role for-

IGF-I in aging regulation. If down-regulation of IGF-I activity

could indeed slow aging in humans, a range of practical measures for

achieving this may be at hand. These include a low-fat, whole-food,

vegan diet, exercise training, soluble fiber, insulin sensitizers,

appetite suppressants, and agents such as flax lignans, oral

estrogen, or tamoxifen that decrease hepatic synthesis of IGF-I.

Many of these measures would also be expected to decrease risk for

common age-related diseases. Regimens combining several of these

approaches might have a sufficient impact on IGF-I activity to

achieve a useful retardation of the aging process. However, in light

of the fact that IGF-I promotes endothelial production of nitric

oxide and may be of especial importance to cerebrovascular health,

additional measures for stroke prevention-most notably salt

restriction-may be advisable when attempting to down-regulate IGF-I

activity as a pro-longevity strategy. "

PMID: 12699704

Rodney.