Re: Calorie Restriction and Body Weight -- some facts

[Guest guest]

There clearly were some flaws in this paper and it cannot be used in

favour or against increasing levels of CR beyond 15%

So what happens when you go to higher levels of CR, you generally

become skinny, and at even higher levels of CR you become skinnier

still. So how did these guys measure up?

The groups were split into 5 qunitiles.

Table.1

Q1 1407k/cal... BMI 24.6

Q2 1882k/cal... BMI 23.9

Q3 2214 k/cal... BMI 24.2

Q4 2581 k/cal... BMI 24.0

Q5 3212k/cal... BMI 24.3

P:F:C ratio were maintained at similar levels among all groups.

" One single measurement of dietery intake was undertaken during the

36 year followup. "

" typical 24 hour diet recall data understimates engery intake by as

much as 20 "

Many other problems with the study... scrap it IMO.

Matt

> >

> > Some time ago, I posted about how CR affects body weight. I have

been

> > able to correlate the results of the Mifflin-St Jeor energy

equation

> > for humans with the experimental results for CR mouse weight.

> >

> > Another CRONie and I collaborated to derive the mouse equations

from

> > the Mifflin-St Jeor equations. I feel that this provides very

strong

> > evidence that similar limiting mechanisms between nutrition and

body

> > weight may be involved for different species.

> >

> > I have created a web page that shows the graphs and the

mathematical

> > derivation:

> > http://www.scientificpsychic.com/health/CR-weight.html

> >

> > One interesting conclusion from this analysis was that for CR

started

> > in adulthood the maximum safe Percent CR is around 16% CR. This

also

> > seems to correlate with the findings in the following study:

> >

> > Willcox BJ, Yano K, Chen R, Willcox DC, BL, Masaki KH,

> > Donlon T, Tanaka B, Curb JD., How much should we eat? The

association

> > between energy intake and mortality in a 36-year follow-up study

of

> > Japanese-American men, J Gerontol A Biol Sci Med Sci., 2004

> > Aug;59(8):789-95. PMID: 15345727

> > " After adjustment for age and other confounders, there was a trend

> > toward lower mortality in the second quintile of energy intake,

> > suggesting that men who consumed 15% below the group mean were at

the

> > lowest risk for all-cause mortality. Increased mortality was seen

with

> > intakes below 50% of group mean. "

> >

> > Tony Zamora

> >

>