Calorie Restriction and Body Weight

[Guest guest]

Some time ago, I posted about how CR affects body weight. I have been

able to correlate the results of the Mifflin-St Jeor energy equation

for humans with the experimental results for CR mouse weight.

Another CRONie and I collaborated to derive the mouse equations from

the Mifflin-St Jeor equations. I feel that this provides very strong

evidence that similar limiting mechanisms between nutrition and body

weight may be involved for different species.

I have created a web page that shows the graphs and the mathematical

derivation:

http://www.scientificpsychic.com/health/CR-weight.html

One interesting conclusion from this analysis was that for CR started

in adulthood the maximum safe Percent CR is around 16% CR. This also

seems to correlate with the findings in the following study:

Willcox BJ, Yano K, Chen R, Willcox DC, BL, Masaki KH,

Donlon T, Tanaka B, Curb JD., How much should we eat? The association

between energy intake and mortality in a 36-year follow-up study of

Japanese-American men, J Gerontol A Biol Sci Med Sci., 2004

Aug;59(8):789-95. PMID: 15345727

" After adjustment for age and other confounders, there was a trend

toward lower mortality in the second quintile of energy intake,

suggesting that men who consumed 15% below the group mean were at the

lowest risk for all-cause mortality. Increased mortality was seen with

intakes below 50% of group mean. "

Tony Zamora