Resveratrol in the news again

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A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction

and Retards Aging Parameters in Mice

Link to PLoS journal article: http://snipurl.com/2dpxj

Abstract

Resveratrol in high doses has been shown to extend lifespan in some

studies in invertebrates and to prevent early mortality in mice fed a

high-fat diet. We fed mice from middle age (14-months) to old age

(30-months) either a control diet, a low dose of resveratrol (4.9 mg

kgâˆ'1 dayâˆ'1), or a calorie restricted (CR) diet and examined

genome-wide transcriptional profiles. We report a striking

transcriptional overlap of CR and resveratrol in heart, skeletal

muscle and brain. Both dietary interventions inhibit gene expression

profiles associated with cardiac and skeletal muscle aging, and

prevent age-related cardiac dysfunction. Dietary resveratrol also

mimics the effects of CR in insulin mediated glucose uptake in muscle.

Gene expression profiling suggests that both CR and resveratrol may

retard some aspects of aging through alterations in chromatin

structure and transcription. Resveratrol, at doses that can be readily

achieved in humans, fulfills the definition of a dietary compound that

mimics some aspects of CR.