Re: Has Anyone heard of this?

[Guest guest]

BLABLA... one can find dozen like that searching the web.

Sorry hundreds,each one the best of all.

Only my humble opinion,I do not wish to hurt.

Georgio

> Has anyone heard of this, or tried it? I found it while cruising

on

> the web.

>

> NFI,

>

>

> *************************

>

>

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[Guest guest]

Hi ,

I just wanted to comment on the cholesterol drug

reducing relaspses that your friend may end up taking.

Read through the article at the link I included and

you'll see. I appears that in some cases the maybe a

mold related and that the statins drugs used to

control cholesterol have anti-fungal properties.

This what I'm investigating as the cause for my as of

yet undiagnosis symptoms.

Ciao

Elio

http://www.mercola.com/2003/jul/19/multiple_sclerosis.htm

--- mitzi0099 <mitzi0099@...> wrote:

---------------------------------

I have a friend at work who also has MS. Currently

she is taking

Copaxone. Her doctor told her when she turns 50 she

could stop

taking the injections, you're less likely to relapse!?

She doesn't

want to stop the injections.

I've told her about LDN but her doctor refuses to

prescribe it for

her. He says there isn't enough information to

support it's use,

yeah whatever. Anyway, she is going to continue the

Copaxone and he

told her about a cholesterol drug that taken with

Copaxone is supposed

to help reduce relapses or something like that. Sorry

I don't know the

name of the drug.

Any information about the cholesterol drug would be

great. I am

helping her get more information to show her doctor

LDN could work

for

her.

[Guest guest]

, a couple of months back I saw a neurologist at Yale

University. She refused me LDN but asked if I would like to

participate in a trial using a cholesterol drug. I beleive you can get

info on all the trial if you call the Yale MS center. Hope this helps

Anyway, she is going to continue the Copaxone and he

> told her about a cholesterol drug that taken with Copaxone is

supposed

> to help reduce relapses or something like that. Sorry I don't know

the

> name of the drug.

>

> Any information about the cholesterol drug would be great. I am

> helping her get more information to show her doctor LDN could work

> for

> her.

>

>

[Guest guest]

There have been some reports of people using cholesterol drugs (Satins) for MS which have been favourable. I would however say that there have also been many reports of serious side effects (not listed on the manufactures data) so I think a personal check on side effects would be essential before considering Satins. Sorry not to be more specific but some of the reported side effects have been serious but since we have not considered using them being more than happy with LDN it is not a subject I have studied in depth.

Dave

Message: 6 Date: Thu, 01 Sep 2005 17:37:30 -0000 From: "julespalaia" <julespalaia@...>Subject: Re: Has anyone heard of this?, a couple of months back I saw a neurologist at Yale University. She refused me LDN but asked if I would like to participate in a trial using a cholesterol drug. I beleive you can get info on all the trial if you call the Yale MS center. Hope this helps Anyway, she is going to continue the Copaxone and he > told her about a cholesterol drug that taken with Copaxone is supposed > to help reduce relapses or something like that. Sorry I don't know the > name of the drug.> > Any information about the cholesterol drug would be great. I am > helping her get more information to show her doctor LDN could work> for > her.> >

[Guest guest]

Hi ,

Have a look at this website. It explains why statins

are effective. Statins have anti-fungal properties and

it is thought that in some cases MS can be a chronic

fungal infection.

Ciao

Elio

--- <davidtaylor@...> wrote:

> There have been some reports of people using

> cholesterol drugs (Satins) for MS which have been

> favourable. I would however say that there have also

> been many reports of serious side effects (not

> listed on the manufactures data) so I think a

> personal check on side effects would be essential

> before considering Satins. Sorry not to be more

> specific but some of the reported side effects have

> been serious but since we have not considered using

> them being more than happy with LDN it is not a

> subject I have studied in depth.

>

> Dave

>

> Message: 6

> Date: Thu, 01 Sep 2005 17:37:30 -0000

> From: " julespalaia " <julespalaia@...>

> Subject: Re: Has anyone heard of this?

>

> , a couple of months back I saw a neurologist

> at Yale

> University. She refused me LDN but asked if I would

> like to

> participate in a trial using a cholesterol drug. I

> beleive you can get

> info on all the trial if you call the Yale MS

> center. Hope this helps

>

>

>

>

> Anyway, she is going to continue the Copaxone and

> he

> > told her about a cholesterol drug that taken with

> Copaxone is

> supposed

> > to help reduce relapses or something like that.

> Sorry I don't know

> the

> > name of the drug.

> >

> > Any information about the cholesterol drug would

> be great. I am

> > helping her get more information to show her

> doctor LDN could work

> > for

> > her.

> >

> >

>

>

>

>

__________________________________________________________

Find your next car at http://autos..ca

[Guest guest]

Here's a probable explanation as to why statin drugs may be helpful:

http://tinyurl.com/cne72

The drugs being tested are Lipitor and Zocor. They have a pretty

good side effect profile--docs must check for liver problems and

muscle issues. Also, some people complain of cognitive problems, but

overall, probably 90% of folks have no problems.

If you take a statin, you should take CoQ10 as well, since that is

depleted by statin drugs.

> I have a friend at work who also has MS. Currently she is taking

> Copaxone. Her doctor told her when she turns 50 she could stop

> taking the injections, you're less likely to relapse!? She doesn't

> want to stop the injections.

>

> I've told her about LDN but her doctor refuses to prescribe it for

> her. He says there isn't enough information to support it's use,

> yeah whatever. Anyway, she is going to continue the Copaxone and

he

> told her about a cholesterol drug that taken with Copaxone is

supposed

> to help reduce relapses or something like that. Sorry I don't know

the

> name of the drug.

>

> Any information about the cholesterol drug would be great. I am

> helping her get more information to show her doctor LDN could work

> for

> her.

>

>

[Guest guest]

SAndie,

I have. Ihae been threw two rheummies and I am working on my third one. I

am also one of those people that can NOT take MTX. Enbrel does not work...and

I refused remicaide or humira. There are many other drugs that I can not

take due to allergies or side effects.

Give the new doc a chance. Sometimes you have to rotate the drugs all

around to make it work. Sounds like he is not interested at really treating

you

and even doubts the diagnosis to a certain point. Sad.....

My new rheummy did the same thing. We stopped all meds and then started back

with ONE med a time to see if it was really helping or causeing other

problems. So far I am on plaquinil, lodine as needed, nexium when I take the

lodine and sleep meds when I need them. Most days I take plaquinil and that's

it.

I saw my rheummy yesterday and got my second steriod shot in my hip. He

said I can only get 4 a year so he hopes this will give me relief.

Good luck with you new doc.

Toni in Texas

In a message dated 10/26/2005 5:35:25 A.M. Central Daylight Time,

writes:

Date: Tue, 25 Oct 2005 20:11:35 EDT

From: slmcc93@...

Subject: has anyone heard of this?

Well, Today I went back to my rheumy. I told him the MTX doesn't seem to be

working anymore as I have more pain in my hands and feet and basically all

over. I told him when the pain hits my toes and fingers it is hot and

throbbing

and actually hits with such intensity that it turns my stomach. What did he

say

- nothing. He then told me to forget going to the oncologist and took me off

all my meds. No more plaquenil, mtx and folic acid. He said we " will do an

experiment with prednisone. " I will be taking the prednisone for 3 weeks 20

mg a

day for two weeks and then tapering off slowly. if that works to help me

with

the pain he will put me on a mtx typ drug again. if that doesnt work he is

done with me. He said i " fall in the gray zone. my blood work doesnt show

the RA

per say so there is nothing else he can do for me. " He suggested a pain

management doc or my pcp to prescribe pain meds for me but that is it. He

does say I

have psoriatic arthritis.

I am completely disgusted. I am in constant pain- and he doesnt seem to

care.

My worry is that I DO have RA and if left untreated I will have a host of

problems later in life and he of course will be long gone. as far as I am

concerned I am done with this doctor(and i use that term loosely) I will

however take

the prednisone for the next 3 weeks and see him but that is it. I have his

appointment on the 15th and my new pcp on the 17th. Things coundt have

worked

out better there. so I will then take my records and get a referral for the

last

rheumy in my insurance plan. Help everyone has anyone had this type of thing

happen to them and if yes what have you done? any and all advice is greatly

appreciated. I am at the end of my rope at 34years old. I cant take it

anymore.

i jsut want to not have pain. The only good thing this guy did was give me a

script for the lortab and 2 refills. but ven there I am just tired of the

pain

meds as they dont even give much relief.

sorry to complain so much i am just so tired. then dear hubby said " you

shouldnt let it ruin your night " UGH!!!!!!! I will not even get into that!

hugs to all

sandie

[Guest guest]

SAndie,

I have. Ihae been threw two rheummies and I am working on my third one. I

am also one of those people that can NOT take MTX. Enbrel does not work...and

I refused remicaide or humira. There are many other drugs that I can not

take due to allergies or side effects.

Give the new doc a chance. Sometimes you have to rotate the drugs all

around to make it work. Sounds like he is not interested at really treating

you

and even doubts the diagnosis to a certain point. Sad.....

My new rheummy did the same thing. We stopped all meds and then started back

with ONE med a time to see if it was really helping or causeing other

problems. So far I am on plaquinil, lodine as needed, nexium when I take the

lodine and sleep meds when I need them. Most days I take plaquinil and that's

it.

I saw my rheummy yesterday and got my second steriod shot in my hip. He

said I can only get 4 a year so he hopes this will give me relief.

Good luck with you new doc.

Toni in Texas

In a message dated 10/26/2005 5:35:25 A.M. Central Daylight Time,

writes:

Date: Tue, 25 Oct 2005 20:11:35 EDT

From: slmcc93@...

Subject: has anyone heard of this?

Well, Today I went back to my rheumy. I told him the MTX doesn't seem to be

working anymore as I have more pain in my hands and feet and basically all

over. I told him when the pain hits my toes and fingers it is hot and

throbbing

and actually hits with such intensity that it turns my stomach. What did he

say

- nothing. He then told me to forget going to the oncologist and took me off

all my meds. No more plaquenil, mtx and folic acid. He said we " will do an

experiment with prednisone. " I will be taking the prednisone for 3 weeks 20

mg a

day for two weeks and then tapering off slowly. if that works to help me

with

the pain he will put me on a mtx typ drug again. if that doesnt work he is

done with me. He said i " fall in the gray zone. my blood work doesnt show

the RA

per say so there is nothing else he can do for me. " He suggested a pain

management doc or my pcp to prescribe pain meds for me but that is it. He

does say I

have psoriatic arthritis.

I am completely disgusted. I am in constant pain- and he doesnt seem to

care.

My worry is that I DO have RA and if left untreated I will have a host of

problems later in life and he of course will be long gone. as far as I am

concerned I am done with this doctor(and i use that term loosely) I will

however take

the prednisone for the next 3 weeks and see him but that is it. I have his

appointment on the 15th and my new pcp on the 17th. Things coundt have

worked

out better there. so I will then take my records and get a referral for the

last

rheumy in my insurance plan. Help everyone has anyone had this type of thing

happen to them and if yes what have you done? any and all advice is greatly

appreciated. I am at the end of my rope at 34years old. I cant take it

anymore.

i jsut want to not have pain. The only good thing this guy did was give me a

script for the lortab and 2 refills. but ven there I am just tired of the

pain

meds as they dont even give much relief.

sorry to complain so much i am just so tired. then dear hubby said " you

shouldnt let it ruin your night " UGH!!!!!!! I will not even get into that!

hugs to all

sandie

[Guest guest]

If you suspect your child has learning issues or speech issues for that matter,

it is important to have an independent neuropsychological evaluation. These are

tests (lots of questions and pictures) that help to understand how your child's

brain works and learns. It is specific to your child. If your child has a

'language processing' issue the psychologist will use tests to better understand

what your child is hearing/learning (receptive lang) vs what they may be capable

of expressing (expressive lang).They should be able to help understand what kind

of support your child witllneed for reading, comprehension, writing, math. If

your child has trouble with speech (speed, clarity etc) you should have a Speech

and Lang Eval which help to understand what may be causing and more importatnly

how the school should support your child to her learning potential. Also, if

your child has problems with transistions mention this to your evaluator for

neuropsyche b/c oftern our kids

are given service outside the classroom which only increases transitions in/out

and often results in meltdowns and anxiety. You may want to see if your school

can support your child in the clssroom in small group which benefits all the

kids!

As well, if your child needs support services in school, such as speech/lang,

direct reading instruction etc, your school will want to do its own testing too

and put your child on an individual educational plan (IEP). Also get some

standardized testing written into the IEP so annual you can see how your child

is doing vs. grade AND age level equivalents. I stress getting this written

into the IEP.

Look locally and see if there is a parent special education group that can

give you more information about your school and how things are done there.

Hope this helps. It is very frustrating to not get the whole picture or not get

it in a timely fashion.

k

" mama.duck " <mama.duck@...> wrote:

Hello...I'm new here. I have 3 daughters. My oldest is 8. We often

wondered when listening to other small children if she had a speech

delay, but she filled the requirements of the developmental questions

the pediatrician always asked so I doubted my own concerns. Luckily,

we had her tested before entering Kindergarten and it was found that

she had a problem with comprehension and communication...maybe that's

the same. I've talked and listened and have tried throught the years

to understand. I get it when I'm hearing it, but when I leave I'm

lost and could never explain it to anyone else. There is no

particular name for this so I have no way that I know of to do

further research.

She used to be unable to answer " W " questions. She can now, but with

a little difficulty. For example;

Where are your shoes?

What did you do today?

Why did you decide to do that?

When did you brush your teeth?

She gives what sounds like crazy answers to simple questions until

they are rephrased;

Can you find your shoes? We need to go...

Did anything interesting happen today?

and so on and so on...

Also, she reads on a level below her grade level. I did not know

that until recently even though I've always made regular meetings

with her teacher and speech teacher at school. It was only recently

that they revealed that on the progress reports that she reads on her

grade level 'for her'. In other words, they have always made it seem

like she reads at grade level but add a star which means it's really

a grade below. Isn't that crazy? I felt so lied to! It explained

so much that I won't go into right now. Anyway, so she'll read a

book and although I know she can read the story and we could read it

a million times, she can't seem to answer questions about what she

has read unless you go back into the book to find the answers...and I

mean very basic, general sort of questions that aren't difficult.

Another thing like this is, well, say she is sitting in the kitchen

and I ask her to describe the stove. She can do that just fine as

long as she can see it. If she can't see it, however, she can't

describe it at all...she has to be looking at something to describe

it, as though her mind just can't picture it at all.

So these are the things my daughter gets help for and I'm so sick of

not understanding...seeking understanding, thinking I've got it and

then I don't. I'm sick of asking these people how I can help and

being told to lay off her, let her read easy books if she wants and

to help extend her vocabulary by talking about the world around us

more. Not that this isn't good advice, but I mean more...I mean what

more can we do to help her? Is the school help really enough? Are

there more options? Does anyone here know what I'm talking about and

could maybe help me out in understanding what's going on? Or knows a

site I could find information on? I'm scared for my daughter...I

want her to have a nice life. She just trudges through school...and

beats herself up so much. I want her to feel good.

thank you,

mama duck

[Guest guest]

If you suspect your child has learning issues or speech issues for that matter,

it is important to have an independent neuropsychological evaluation. These are

tests (lots of questions and pictures) that help to understand how your child's

brain works and learns. It is specific to your child. If your child has a

'language processing' issue the psychologist will use tests to better understand

what your child is hearing/learning (receptive lang) vs what they may be capable

of expressing (expressive lang).They should be able to help understand what kind

of support your child witllneed for reading, comprehension, writing, math. If

your child has trouble with speech (speed, clarity etc) you should have a Speech

and Lang Eval which help to understand what may be causing and more importatnly

how the school should support your child to her learning potential. Also, if

your child has problems with transistions mention this to your evaluator for

neuropsyche b/c oftern our kids

are given service outside the classroom which only increases transitions in/out

and often results in meltdowns and anxiety. You may want to see if your school

can support your child in the clssroom in small group which benefits all the

kids!

As well, if your child needs support services in school, such as speech/lang,

direct reading instruction etc, your school will want to do its own testing too

and put your child on an individual educational plan (IEP). Also get some

standardized testing written into the IEP so annual you can see how your child

is doing vs. grade AND age level equivalents. I stress getting this written

into the IEP.

Look locally and see if there is a parent special education group that can

give you more information about your school and how things are done there.

Hope this helps. It is very frustrating to not get the whole picture or not get

it in a timely fashion.

k

" mama.duck " <mama.duck@...> wrote:

Hello...I'm new here. I have 3 daughters. My oldest is 8. We often

wondered when listening to other small children if she had a speech

delay, but she filled the requirements of the developmental questions

the pediatrician always asked so I doubted my own concerns. Luckily,

we had her tested before entering Kindergarten and it was found that

she had a problem with comprehension and communication...maybe that's

the same. I've talked and listened and have tried throught the years

to understand. I get it when I'm hearing it, but when I leave I'm

lost and could never explain it to anyone else. There is no

particular name for this so I have no way that I know of to do

further research.

She used to be unable to answer " W " questions. She can now, but with

a little difficulty. For example;

Where are your shoes?

What did you do today?

Why did you decide to do that?

When did you brush your teeth?

She gives what sounds like crazy answers to simple questions until

they are rephrased;

Can you find your shoes? We need to go...

Did anything interesting happen today?

and so on and so on...

Also, she reads on a level below her grade level. I did not know

that until recently even though I've always made regular meetings

with her teacher and speech teacher at school. It was only recently

that they revealed that on the progress reports that she reads on her

grade level 'for her'. In other words, they have always made it seem

like she reads at grade level but add a star which means it's really

a grade below. Isn't that crazy? I felt so lied to! It explained

so much that I won't go into right now. Anyway, so she'll read a

book and although I know she can read the story and we could read it

a million times, she can't seem to answer questions about what she

has read unless you go back into the book to find the answers...and I

mean very basic, general sort of questions that aren't difficult.

Another thing like this is, well, say she is sitting in the kitchen

and I ask her to describe the stove. She can do that just fine as

long as she can see it. If she can't see it, however, she can't

describe it at all...she has to be looking at something to describe

it, as though her mind just can't picture it at all.

So these are the things my daughter gets help for and I'm so sick of

not understanding...seeking understanding, thinking I've got it and

then I don't. I'm sick of asking these people how I can help and

being told to lay off her, let her read easy books if she wants and

to help extend her vocabulary by talking about the world around us

more. Not that this isn't good advice, but I mean more...I mean what

more can we do to help her? Is the school help really enough? Are

there more options? Does anyone here know what I'm talking about and

could maybe help me out in understanding what's going on? Or knows a

site I could find information on? I'm scared for my daughter...I

want her to have a nice life. She just trudges through school...and

beats herself up so much. I want her to feel good.

thank you,

mama duck

[Guest guest]

" it is important to have an independent neuropsychological

evaluation "

Hope this isn't a stupid question, but who would provide an

evaluation like this--neurologist, psychyatrist/psychologist, or is

there such a thing as a neuropsychologist?

> Hello...I'm new here. I have 3 daughters. My oldest is

8. We often

> wondered when listening to other small children if she had a

speech

> delay, but she filled the requirements of the developmental

questions

> the pediatrician always asked so I doubted my own concerns.

Luckily,

> we had her tested before entering Kindergarten and it was found

that

> she had a problem with comprehension and communication...maybe

that's

> the same. I've talked and listened and have tried throught the

years

> to understand. I get it when I'm hearing it, but when I leave I'm

> lost and could never explain it to anyone else. There is no

> particular name for this so I have no way that I know of to do

> further research.

>

> She used to be unable to answer " W " questions. She can now, but

with

> a little difficulty. For example;

> Where are your shoes?

> What did you do today?

> Why did you decide to do that?

> When did you brush your teeth?

> She gives what sounds like crazy answers to simple questions until

> they are rephrased;

> Can you find your shoes? We need to go...

> Did anything interesting happen today?

> and so on and so on...

>

> Also, she reads on a level below her grade level. I did not know

> that until recently even though I've always made regular meetings

> with her teacher and speech teacher at school. It was only

recently

> that they revealed that on the progress reports that she reads on

her

> grade level 'for her'. In other words, they have always made it

seem

> like she reads at grade level but add a star which means it's

really

> a grade below. Isn't that crazy? I felt so lied to! It explained

> so much that I won't go into right now. Anyway, so she'll read a

> book and although I know she can read the story and we could read

it

> a million times, she can't seem to answer questions about what she

> has read unless you go back into the book to find the

answers...and I

> mean very basic, general sort of questions that aren't difficult.

>

> Another thing like this is, well, say she is sitting in the

kitchen

> and I ask her to describe the stove. She can do that just fine as

> long as she can see it. If she can't see it, however, she can't

> describe it at all...she has to be looking at something to

describe

> it, as though her mind just can't picture it at all.

>

> So these are the things my daughter gets help for and I'm so sick

of

> not understanding...seeking understanding, thinking I've got it

and

> then I don't. I'm sick of asking these people how I can help and

> being told to lay off her, let her read easy books if she wants

and

> to help extend her vocabulary by talking about the world around us

> more. Not that this isn't good advice, but I mean more...I mean

what

> more can we do to help her? Is the school help really enough? Are

> there more options? Does anyone here know what I'm talking about

and

> could maybe help me out in understanding what's going on? Or knows

a

> site I could find information on? I'm scared for my daughter...I

> want her to have a nice life. She just trudges through

school...and

> beats herself up so much. I want her to feel good.

>

> thank you,

> mama duck

>

>

>

>

>

>

>

>

[Guest guest]

" it is important to have an independent neuropsychological

evaluation "

Hope this isn't a stupid question, but who would provide an

evaluation like this--neurologist, psychyatrist/psychologist, or is

there such a thing as a neuropsychologist?

> Hello...I'm new here. I have 3 daughters. My oldest is

8. We often

> wondered when listening to other small children if she had a

speech

> delay, but she filled the requirements of the developmental

questions

> the pediatrician always asked so I doubted my own concerns.

Luckily,

> we had her tested before entering Kindergarten and it was found

that

> she had a problem with comprehension and communication...maybe

that's

> the same. I've talked and listened and have tried throught the

years

> to understand. I get it when I'm hearing it, but when I leave I'm

> lost and could never explain it to anyone else. There is no

> particular name for this so I have no way that I know of to do

> further research.

>

> She used to be unable to answer " W " questions. She can now, but

with

> a little difficulty. For example;

> Where are your shoes?

> What did you do today?

> Why did you decide to do that?

> When did you brush your teeth?

> She gives what sounds like crazy answers to simple questions until

> they are rephrased;

> Can you find your shoes? We need to go...

> Did anything interesting happen today?

> and so on and so on...

>

> Also, she reads on a level below her grade level. I did not know

> that until recently even though I've always made regular meetings

> with her teacher and speech teacher at school. It was only

recently

> that they revealed that on the progress reports that she reads on

her

> grade level 'for her'. In other words, they have always made it

seem

> like she reads at grade level but add a star which means it's

really

> a grade below. Isn't that crazy? I felt so lied to! It explained

> so much that I won't go into right now. Anyway, so she'll read a

> book and although I know she can read the story and we could read

it

> a million times, she can't seem to answer questions about what she

> has read unless you go back into the book to find the

answers...and I

> mean very basic, general sort of questions that aren't difficult.

>

> Another thing like this is, well, say she is sitting in the

kitchen

> and I ask her to describe the stove. She can do that just fine as

> long as she can see it. If she can't see it, however, she can't

> describe it at all...she has to be looking at something to

describe

> it, as though her mind just can't picture it at all.

>

> So these are the things my daughter gets help for and I'm so sick

of

> not understanding...seeking understanding, thinking I've got it

and

> then I don't. I'm sick of asking these people how I can help and

> being told to lay off her, let her read easy books if she wants

and

> to help extend her vocabulary by talking about the world around us

> more. Not that this isn't good advice, but I mean more...I mean

what

> more can we do to help her? Is the school help really enough? Are

> there more options? Does anyone here know what I'm talking about

and

> could maybe help me out in understanding what's going on? Or knows

a

> site I could find information on? I'm scared for my daughter...I

> want her to have a nice life. She just trudges through

school...and

> beats herself up so much. I want her to feel good.

>

> thank you,

> mama duck

>

>

>

>

>

>

>

>

[Guest guest]

Typically, it is a psychologist and yes there are even certifications for

neuropsychologists but not in all parts of the country. THis appears to be an

emerging trend as psychologist try to set themselves apart. THis is also, in my

opinion, a growing, big business b/c schools are requiring more proof before

offering appropriate services and placements.

What you want to do is find a highly recommended in your area. Look to your

local spec ed parent group through the school (if they have one). Call the

developmental area of the nearest large teaching hospital and find out if they

have a list. Best if you can find out from other parents if they liked the

doctor's report, timeliness, availability for school mtgs etc. You may want to

find someone who will attend your school mtg to defend his/her report and

communicate with the TEAM. Most do not do this and you have to pay for it.

If your child qualifies for school testing you may be entitled to have the

school district pay for this exam which is expensive (can run from $2000-$3000).

My insurance covered it (hmo) b/c of her medical needs to track development.

Insurance will not cover it usually if it is only for educational purposes so

you may want to work with your doctor to get referral (or neurologist even

better).

hope this helps

karen

myjunkytrash <myjunkytrash@...> wrote:

" it is important to have an independent neuropsychological

evaluation "

Hope this isn't a stupid question, but who would provide an

evaluation like this--neurologist, psychyatrist/psychologist, or is

there such a thing as a neuropsychologist?

> Hello...I'm new here. I have 3 daughters. My oldest is

8. We often

> wondered when listening to other small children if she had a

speech

> delay, but she filled the requirements of the developmental

questions

> the pediatrician always asked so I doubted my own concerns.

Luckily,

> we had her tested before entering Kindergarten and it was found

that

> she had a problem with comprehension and communication...maybe

that's

> the same. I've talked and listened and have tried throught the

years

> to understand. I get it when I'm hearing it, but when I leave I'm

> lost and could never explain it to anyone else. There is no

> particular name for this so I have no way that I know of to do

> further research.

>

> She used to be unable to answer " W " questions. She can now, but

with

> a little difficulty. For example;

> Where are your shoes?

> What did you do today?

> Why did you decide to do that?

> When did you brush your teeth?

> She gives what sounds like crazy answers to simple questions until

> they are rephrased;

> Can you find your shoes? We need to go...

> Did anything interesting happen today?

> and so on and so on...

>

> Also, she reads on a level below her grade level. I did not know

> that until recently even though I've always made regular meetings

> with her teacher and speech teacher at school. It was only

recently

> that they revealed that on the progress reports that she reads on

her

> grade level 'for her'. In other words, they have always made it

seem

> like she reads at grade level but add a star which means it's

really

> a grade below. Isn't that crazy? I felt so lied to! It explained

> so much that I won't go into right now. Anyway, so she'll read a

> book and although I know she can read the story and we could read

it

> a million times, she can't seem to answer questions about what she

> has read unless you go back into the book to find the

answers...and I

> mean very basic, general sort of questions that aren't difficult.

>

> Another thing like this is, well, say she is sitting in the

kitchen

> and I ask her to describe the stove. She can do that just fine as

> long as she can see it. If she can't see it, however, she can't

> describe it at all...she has to be looking at something to

describe

> it, as though her mind just can't picture it at all.

>

> So these are the things my daughter gets help for and I'm so sick

of

> not understanding...seeking understanding, thinking I've got it

and

> then I don't. I'm sick of asking these people how I can help and

> being told to lay off her, let her read easy books if she wants

and

> to help extend her vocabulary by talking about the world around us

> more. Not that this isn't good advice, but I mean more...I mean

what

> more can we do to help her? Is the school help really enough? Are

> there more options? Does anyone here know what I'm talking about

and

> could maybe help me out in understanding what's going on? Or knows

a

> site I could find information on? I'm scared for my daughter...I

> want her to have a nice life. She just trudges through

school...and

> beats herself up so much. I want her to feel good.

>

> thank you,

> mama duck

>

>

>

>

>

>

>

>

[Guest guest]

Typically, it is a psychologist and yes there are even certifications for

neuropsychologists but not in all parts of the country. THis appears to be an

emerging trend as psychologist try to set themselves apart. THis is also, in my

opinion, a growing, big business b/c schools are requiring more proof before

offering appropriate services and placements.

What you want to do is find a highly recommended in your area. Look to your

local spec ed parent group through the school (if they have one). Call the

developmental area of the nearest large teaching hospital and find out if they

have a list. Best if you can find out from other parents if they liked the

doctor's report, timeliness, availability for school mtgs etc. You may want to

find someone who will attend your school mtg to defend his/her report and

communicate with the TEAM. Most do not do this and you have to pay for it.

If your child qualifies for school testing you may be entitled to have the

school district pay for this exam which is expensive (can run from $2000-$3000).

My insurance covered it (hmo) b/c of her medical needs to track development.

Insurance will not cover it usually if it is only for educational purposes so

you may want to work with your doctor to get referral (or neurologist even

better).

hope this helps

karen

myjunkytrash <myjunkytrash@...> wrote:

" it is important to have an independent neuropsychological

evaluation "

Hope this isn't a stupid question, but who would provide an

evaluation like this--neurologist, psychyatrist/psychologist, or is

there such a thing as a neuropsychologist?

> Hello...I'm new here. I have 3 daughters. My oldest is

8. We often

> wondered when listening to other small children if she had a

speech

> delay, but she filled the requirements of the developmental

questions

> the pediatrician always asked so I doubted my own concerns.

Luckily,

> we had her tested before entering Kindergarten and it was found

that

> she had a problem with comprehension and communication...maybe

that's

> the same. I've talked and listened and have tried throught the

years

> to understand. I get it when I'm hearing it, but when I leave I'm

> lost and could never explain it to anyone else. There is no

> particular name for this so I have no way that I know of to do

> further research.

>

> She used to be unable to answer " W " questions. She can now, but

with

> a little difficulty. For example;

> Where are your shoes?

> What did you do today?

> Why did you decide to do that?

> When did you brush your teeth?

> She gives what sounds like crazy answers to simple questions until

> they are rephrased;

> Can you find your shoes? We need to go...

> Did anything interesting happen today?

> and so on and so on...

>

> Also, she reads on a level below her grade level. I did not know

> that until recently even though I've always made regular meetings

> with her teacher and speech teacher at school. It was only

recently

> that they revealed that on the progress reports that she reads on

her

> grade level 'for her'. In other words, they have always made it

seem

> like she reads at grade level but add a star which means it's

really

> a grade below. Isn't that crazy? I felt so lied to! It explained

> so much that I won't go into right now. Anyway, so she'll read a

> book and although I know she can read the story and we could read

it

> a million times, she can't seem to answer questions about what she

> has read unless you go back into the book to find the

answers...and I

> mean very basic, general sort of questions that aren't difficult.

>

> Another thing like this is, well, say she is sitting in the

kitchen

> and I ask her to describe the stove. She can do that just fine as

> long as she can see it. If she can't see it, however, she can't

> describe it at all...she has to be looking at something to

describe

> it, as though her mind just can't picture it at all.

>

> So these are the things my daughter gets help for and I'm so sick

of

> not understanding...seeking understanding, thinking I've got it

and

> then I don't. I'm sick of asking these people how I can help and

> being told to lay off her, let her read easy books if she wants

and

> to help extend her vocabulary by talking about the world around us

> more. Not that this isn't good advice, but I mean more...I mean

what

> more can we do to help her? Is the school help really enough? Are

> there more options? Does anyone here know what I'm talking about

and

> could maybe help me out in understanding what's going on? Or knows

a

> site I could find information on? I'm scared for my daughter...I

> want her to have a nice life. She just trudges through

school...and

> beats herself up so much. I want her to feel good.

>

> thank you,

> mama duck

>

>

>

>

>

>

>

>

[Guest guest]

This sounds a bit like my son, but he's younger. He's not reading yet. I

started to become concerned he might have some auditory processing issues. His

SLP and OT (with listening therapy) are working on it. It seems to be a lot of

repetition. Almost like we are building new pathways or at least reorganizing

the old ones.

His SLP did say not all kids with apraxia have auditory processing, but it's

not uncommon for them to co-exist. Which makes sense since it's a pathway

issue. Just like I recently read someone asking about children with apraxia

have some vision issues.

A few things I'd like to point out. One is " reading for her grade level " is a

big cop out to me. It's just a way to say " that's all she/he is capable of so

we don't have to work any harder " ... Having apraxia and co-relating issues does

not equal cognitive issues and please do NOT let them even go there. With my

son the SLP (public school) tried to say (after she'd seen him twice) that maybe

it was cognitive. I looked her right in the eyes and said " FINE, let's

cognitively test him NOW and your not using a verbal IQ test either. " .. That

ended that issue right there. They knew it was cognitive it was just a cop out

not to have to work harder. The explained the bar is set at what they feel they

are capable of doing not where their peers are.. I didn't like that one bit.

My son has language issues related to his Apraxia. He has soared so much on

expressive (still has the S lisp, etc.) that they have stopped working on that

nearly as much and are now working on receptive. ie- language and

understanding. There's been a few days I wondered if it's cognitive and that

would be OK, I love him any way he comes. BUT then I see him whip a 75 piece

puzzle together. Or stack chairs up, stand on them, and use the attic hook to

pull something out of the cupboard. Or I catch him in a room with the coffee

maker and say " what are you doing " and he says " figuring out how this machine

works " ..

Sorry to be so long winded.. I hope I'm explaining this OK.. My advice would

be to try to look into auditory processing testing/issues or another co-existing

condition and see if treating that along with the apraxia helps..

Hope this helps!

Amy D

" mama.duck " <mama.duck@...> wrote:

Hello...I'm new here. I have 3 daughters. My oldest is 8. We often

wondered when listening to other small children if she had a speech

delay, but she filled the requirements of the developmental questions

the pediatrician always asked so I doubted my own concerns. Luckily,

we had her tested before entering Kindergarten and it was found that

she had a problem with comprehension and communication...maybe that's

the same. I've talked and listened and have tried throught the years

to understand. I get it when I'm hearing it, but when I leave I'm

lost and could never explain it to anyone else. There is no

particular name for this so I have no way that I know of to do

further research.

She used to be unable to answer " W " questions. She can now, but with

a little difficulty. For example;

Where are your shoes?

What did you do today?

Why did you decide to do that?

When did you brush your teeth?

She gives what sounds like crazy answers to simple questions until

they are rephrased;

Can you find your shoes? We need to go...

Did anything interesting happen today?

and so on and so on...

Also, she reads on a level below her grade level. I did not know

that until recently even though I've always made regular meetings

with her teacher and speech teacher at school. It was only recently

that they revealed that on the progress reports that she reads on her

grade level 'for her'. In other words, they have always made it seem

like she reads at grade level but add a star which means it's really

a grade below. Isn't that crazy? I felt so lied to! It explained

so much that I won't go into right now. Anyway, so she'll read a

book and although I know she can read the story and we could read it

a million times, she can't seem to answer questions about what she

has read unless you go back into the book to find the answers...and I

mean very basic, general sort of questions that aren't difficult.

Another thing like this is, well, say she is sitting in the kitchen

and I ask her to describe the stove. She can do that just fine as

long as she can see it. If she can't see it, however, she can't

describe it at all...she has to be looking at something to describe

it, as though her mind just can't picture it at all.

So these are the things my daughter gets help for and I'm so sick of

not understanding...seeking understanding, thinking I've got it and

then I don't. I'm sick of asking these people how I can help and

being told to lay off her, let her read easy books if she wants and

to help extend her vocabulary by talking about the world around us

more. Not that this isn't good advice, but I mean more...I mean what

more can we do to help her? Is the school help really enough? Are

there more options? Does anyone here know what I'm talking about and

could maybe help me out in understanding what's going on? Or knows a

site I could find information on? I'm scared for my daughter...I

want her to have a nice life. She just trudges through school...and

beats herself up so much. I want her to feel good.

thank you,

mama duck

---------------------------------

Stay in the know. Pulse on the new .com. Check it out.

[Guest guest]

This sounds a bit like my son, but he's younger. He's not reading yet. I

started to become concerned he might have some auditory processing issues. His

SLP and OT (with listening therapy) are working on it. It seems to be a lot of

repetition. Almost like we are building new pathways or at least reorganizing

the old ones.

His SLP did say not all kids with apraxia have auditory processing, but it's

not uncommon for them to co-exist. Which makes sense since it's a pathway

issue. Just like I recently read someone asking about children with apraxia

have some vision issues.

A few things I'd like to point out. One is " reading for her grade level " is a

big cop out to me. It's just a way to say " that's all she/he is capable of so

we don't have to work any harder " ... Having apraxia and co-relating issues does

not equal cognitive issues and please do NOT let them even go there. With my

son the SLP (public school) tried to say (after she'd seen him twice) that maybe

it was cognitive. I looked her right in the eyes and said " FINE, let's

cognitively test him NOW and your not using a verbal IQ test either. " .. That

ended that issue right there. They knew it was cognitive it was just a cop out

not to have to work harder. The explained the bar is set at what they feel they

are capable of doing not where their peers are.. I didn't like that one bit.

My son has language issues related to his Apraxia. He has soared so much on

expressive (still has the S lisp, etc.) that they have stopped working on that

nearly as much and are now working on receptive. ie- language and

understanding. There's been a few days I wondered if it's cognitive and that

would be OK, I love him any way he comes. BUT then I see him whip a 75 piece

puzzle together. Or stack chairs up, stand on them, and use the attic hook to

pull something out of the cupboard. Or I catch him in a room with the coffee

maker and say " what are you doing " and he says " figuring out how this machine

works " ..

Sorry to be so long winded.. I hope I'm explaining this OK.. My advice would

be to try to look into auditory processing testing/issues or another co-existing

condition and see if treating that along with the apraxia helps..

Hope this helps!

Amy D

" mama.duck " <mama.duck@...> wrote:

Hello...I'm new here. I have 3 daughters. My oldest is 8. We often

wondered when listening to other small children if she had a speech

delay, but she filled the requirements of the developmental questions

the pediatrician always asked so I doubted my own concerns. Luckily,

we had her tested before entering Kindergarten and it was found that

she had a problem with comprehension and communication...maybe that's

the same. I've talked and listened and have tried throught the years

to understand. I get it when I'm hearing it, but when I leave I'm

lost and could never explain it to anyone else. There is no

particular name for this so I have no way that I know of to do

further research.

She used to be unable to answer " W " questions. She can now, but with

a little difficulty. For example;

Where are your shoes?

What did you do today?

Why did you decide to do that?

When did you brush your teeth?

She gives what sounds like crazy answers to simple questions until

they are rephrased;

Can you find your shoes? We need to go...

Did anything interesting happen today?

and so on and so on...

Also, she reads on a level below her grade level. I did not know

that until recently even though I've always made regular meetings

with her teacher and speech teacher at school. It was only recently

that they revealed that on the progress reports that she reads on her

grade level 'for her'. In other words, they have always made it seem

like she reads at grade level but add a star which means it's really

a grade below. Isn't that crazy? I felt so lied to! It explained

so much that I won't go into right now. Anyway, so she'll read a

book and although I know she can read the story and we could read it

a million times, she can't seem to answer questions about what she

has read unless you go back into the book to find the answers...and I

mean very basic, general sort of questions that aren't difficult.

Another thing like this is, well, say she is sitting in the kitchen

and I ask her to describe the stove. She can do that just fine as

long as she can see it. If she can't see it, however, she can't

describe it at all...she has to be looking at something to describe

it, as though her mind just can't picture it at all.

So these are the things my daughter gets help for and I'm so sick of

not understanding...seeking understanding, thinking I've got it and

then I don't. I'm sick of asking these people how I can help and

being told to lay off her, let her read easy books if she wants and

to help extend her vocabulary by talking about the world around us

more. Not that this isn't good advice, but I mean more...I mean what

more can we do to help her? Is the school help really enough? Are

there more options? Does anyone here know what I'm talking about and

could maybe help me out in understanding what's going on? Or knows a

site I could find information on? I'm scared for my daughter...I

want her to have a nice life. She just trudges through school...and

beats herself up so much. I want her to feel good.

thank you,

mama duck

---------------------------------

Stay in the know. Pulse on the new .com. Check it out.

[Guest guest]

This one too:

Autophagy is required for dietary restriction-mediated life span

extension in C. elegans.Jia K, Levine B.

Department of Internal Medicine, University of Texas Southwestern

Medical Center, Dallas, Texas 75390-9113, USA.

Dietary restriction extends life span in diverse species including

Caenorhabditis elegans. However, the downstream cellular targets

regulated by dietary restriction are largely unknown. Autophagy, an

evolutionary conserved lysosomal degradation pathway, is induced

under starvation conditions and regulates life span in insulin

signaling C. elegans mutants. We now report that two essential

autophagy genes (bec-1 and Ce-atg7) are required for the longevity

phenotype of the C. elegans dietary restriction mutant (eat-2(ad1113)

animals. Thus, we propose that autophagy mediates the effect, not

only of insulin signaling, but also of dietary restriction on the

regulation of C. elegans life span. Since autophagy and longevity

control are highly conserved from C. elegans to mammals, a similar

role for autophagy in dietary restriction-mediated life span

extension may also exist in mammals.

PMID: 17912023 [PubMed - indexed for MEDLINE]

>

>

>

>

>

> It seems that autophagy is a key process in extending lifespan of

> Caenorhabditis elegans. One way to increase levels of autophagous

> activity in the body is nutrient starvation. should we be fine-

tuning

> nutrient deficiencies instead of making sure all are supposed needs

> are met.

>

>

>

> 1: Autophagy. 2008 Apr 1;4(3):330-8. Epub 2008 Jan 21. Links

>

> Comment in:

> Autophagy. 2008 Apr 1;4(3):265-7.

> Longevity pathways converge on autophagy genes to regulate life

span

> in Caenorhabditis elegans.Tóth ML, Sigmond T, Borsos E, Barna J,

> Erdélyi P, Takács-Vellai K, Orosz L, Kovács AL, Csikós G, Sass M,

> Vellai T.

> Department of Genetics, Eötvös Loránd University, Budapest, Hungary.

>

> Aging is a multifactorial process with many mechanisms contributing

> to the decline. Mutations decreasing insulin/IGF-1 (insulin-like

> growth factor-1) or TOR (target of rapamycin) kinase-mediated

> signaling, mitochondrial activity and food intake each extend life

> span in divergent animal phyla. Understanding how these genetically

> distinct mechanisms interact to control longevity is a fundamental

> and fascinating problem in biology. Here we show that mutational

> inactivation of autophagy genes, which are involved in the

> degradation of aberrant, damaged cytoplasmic constituents

> accumulating in all aging cells, accelerates the rate at which the

> tissues age in the nematode Caenorhabditis elegans. According to

our

> results Drosophila flies deficient in autophagy are also short-

lived.

> We further demonstrate that reduced activity of autophagy genes

> suppresses life span extension in mutant nematodes with inherent

> dietary restriction, aberrant insulin/IGF-1 or TOR signaling, and

> lowered mitochondrial respiration. These findings suggest that the

> autophagy gene cascade functions downstream of and is inhibited by

> different longevity pathways in C. elegans, therefore, their

effects

> converge on autophagy genes to slow down aging and lengthen life

> span. Thus, autophagy may act as a central regulatory mechanism of

> animal aging.

>

> PMID: 18219227 [PubMed - indexed for MEDLINE]

>

> Autophagy occurs at a basal level in normal growing conditions;

> however, certain types of environmental stress result in a dramatic

> induction. For example, yeast autophagy is induced by nutrient

> starvation, including nitrogen and carbon depletion.

>

> http://www.nature.com/cdd/journal/v12/n2s/full/4401765a.html

>

[Guest guest]

Yes. Some people supplement with certain substances to enhance autophagy as well.On Mon, Sep 1, 2008 at 5:18 PM, Séguin <patrickseguin@...> wrote:

This one too:

Autophagy is required for dietary restriction-mediated life span

extension in C. elegans.Jia K, Levine B.

Department of Internal Medicine, University of Texas Southwestern

Medical Center, Dallas, Texas 75390-9113, USA.

Dietary restriction extends life span in diverse species including

Caenorhabditis elegans. However, the downstream cellular targets

regulated by dietary restriction are largely unknown. Autophagy, an

evolutionary conserved lysosomal degradation pathway, is induced

under starvation conditions and regulates life span in insulin

signaling C. elegans mutants. We now report that two essential

autophagy genes (bec-1 and Ce-atg7) are required for the longevity

phenotype of the C. elegans dietary restriction mutant (eat-2(ad1113)

animals. Thus, we propose that autophagy mediates the effect, not

only of insulin signaling, but also of dietary restriction on the

regulation of C. elegans life span. Since autophagy and longevity

control are highly conserved from C. elegans to mammals, a similar

role for autophagy in dietary restriction-mediated life span

extension may also exist in mammals.

PMID: 17912023 [PubMed - indexed for MEDLINE]

>

>

>

>

>

> It seems that autophagy is a key process in extending lifespan of

> Caenorhabditis elegans. One way to increase levels of autophagous

> activity in the body is nutrient starvation. should we be fine-

tuning

> nutrient deficiencies instead of making sure all are supposed needs

> are met.

>

>

>

> 1: Autophagy. 2008 Apr 1;4(3):330-8. Epub 2008 Jan 21. Links

>

> Comment in:

> Autophagy. 2008 Apr 1;4(3):265-7.

> Longevity pathways converge on autophagy genes to regulate life

span

> in Caenorhabditis elegans.Tóth ML, Sigmond T, Borsos E, Barna J,

> Erdélyi P, Takács-Vellai K, Orosz L, Kovács AL, Csikós G, Sass M,

> Vellai T.

> Department of Genetics, Eötvös Loránd University, Budapest, Hungary.

>

> Aging is a multifactorial process with many mechanisms contributing

> to the decline. Mutations decreasing insulin/IGF-1 (insulin-like

> growth factor-1) or TOR (target of rapamycin) kinase-mediated

> signaling, mitochondrial activity and food intake each extend life

> span in divergent animal phyla. Understanding how these genetically

> distinct mechanisms interact to control longevity is a fundamental

> and fascinating problem in biology. Here we show that mutational

> inactivation of autophagy genes, which are involved in the

> degradation of aberrant, damaged cytoplasmic constituents

> accumulating in all aging cells, accelerates the rate at which the

> tissues age in the nematode Caenorhabditis elegans. According to

our

> results Drosophila flies deficient in autophagy are also short-

lived.

> We further demonstrate that reduced activity of autophagy genes

> suppresses life span extension in mutant nematodes with inherent

> dietary restriction, aberrant insulin/IGF-1 or TOR signaling, and

> lowered mitochondrial respiration. These findings suggest that the

> autophagy gene cascade functions downstream of and is inhibited by

> different longevity pathways in C. elegans, therefore, their

effects

> converge on autophagy genes to slow down aging and lengthen life

> span. Thus, autophagy may act as a central regulatory mechanism of

> animal aging.

>

> PMID: 18219227 [PubMed - indexed for MEDLINE]

>

> Autophagy occurs at a basal level in normal growing conditions;

> however, certain types of environmental stress result in a dramatic

> induction. For example, yeast autophagy is induced by nutrient

> starvation, including nitrogen and carbon depletion.

>

> http://www.nature.com/cdd/journal/v12/n2s/full/4401765a.html

>

[Guest guest]

and : please explain this in lay language.

Thanks in advance.

From: Dowling <christopher.a.dowling@...>

Reply-< >

Date: Mon, 1 Sep 2008 20:31:55 -0400

< >

Subject: Re: [ ] Re: Has Anyone heard of this?

Yes. Some people supplement with certain substances to enhance autophagy as well.

On Mon, Sep 1, 2008 at 5:18 PM, Séguin <patrickseguin@...> wrote:

This one too:

Autophagy is required for dietary restriction-mediated life span

extension in C. elegans.Jia K, Levine B.

Department of Internal Medicine, University of Texas Southwestern

Medical Center, Dallas, Texas 75390-9113, USA.

Dietary restriction extends life span in diverse species including

Caenorhabditis elegans. However, the downstream cellular targets

regulated by dietary restriction are largely unknown. Autophagy, an

evolutionary conserved lysosomal degradation pathway, is induced

under starvation conditions and regulates life span in insulin

signaling C. elegans mutants. We now report that two essential

autophagy genes (bec-1 and Ce-atg7) are required for the longevity

phenotype of the C. elegans dietary restriction mutant (eat-2(ad1113)

animals. Thus, we propose that autophagy mediates the effect, not

only of insulin signaling, but also of dietary restriction on the

regulation of C. elegans life span. Since autophagy and longevity

control are highly conserved from C. elegans to mammals, a similar

role for autophagy in dietary restriction-mediated life span

extension may also exist in mammals.

PMID: 17912023 [PubMed - indexed for MEDLINE]

>

>

>

>

>

> It seems that autophagy is a key process in extending lifespan of

> Caenorhabditis elegans. One way to increase levels of autophagous

> activity in the body is nutrient starvation. should we be fine-

tuning

> nutrient deficiencies instead of making sure all are supposed needs

> are met.

>

>

>

> 1: Autophagy. 2008 Apr 1;4(3):330-8. Epub 2008 Jan 21. Links

>

> Comment in:

> Autophagy. 2008 Apr 1;4(3):265-7.

> Longevity pathways converge on autophagy genes to regulate life

span

> in Caenorhabditis elegans.Tóth ML, Sigmond T, Borsos E, Barna J,

> Erdélyi P, Takács-Vellai K, Orosz L, Kovács AL, Csikós G, Sass M,

> Vellai T.

> Department of Genetics, Eötvös Loránd University, Budapest, Hungary.

>

> Aging is a multifactorial process with many mechanisms contributing

> to the decline. Mutations decreasing insulin/IGF-1 (insulin-like

> growth factor-1) or TOR (target of rapamycin) kinase-mediated

> signaling, mitochondrial activity and food intake each extend life

> span in divergent animal phyla. Understanding how these genetically

> distinct mechanisms interact to control longevity is a fundamental

> and fascinating problem in biology. Here we show that mutational

> inactivation of autophagy genes, which are involved in the

> degradation of aberrant, damaged cytoplasmic constituents

> accumulating in all aging cells, accelerates the rate at which the

> tissues age in the nematode Caenorhabditis elegans. According to

our

> results Drosophila flies deficient in autophagy are also short-

lived.

> We further demonstrate that reduced activity of autophagy genes

> suppresses life span extension in mutant nematodes with inherent

> dietary restriction, aberrant insulin/IGF-1 or TOR signaling, and

> lowered mitochondrial respiration. These findings suggest that the

> autophagy gene cascade functions downstream of and is inhibited by

> different longevity pathways in C. elegans, therefore, their

effects

> converge on autophagy genes to slow down aging and lengthen life

> span. Thus, autophagy may act as a central regulatory mechanism of

> animal aging.

>

> PMID: 18219227 [PubMed - indexed for MEDLINE]

>

> Autophagy occurs at a basal level in normal growing conditions;

> however, certain types of environmental stress result in a dramatic

> induction. For example, yeast autophagy is induced by nutrient

> starvation, including nitrogen and carbon depletion.

>

> http://www.nature.com/cdd/journal/v12/n2s/full/4401765a.html

>

[Guest guest]

Wikipedia explanation is pretty decent.Recent research has linked autophagy to functionality of cells, especially in later life, and, perhaps, as a mechanism by which CR enhances longevity.

Some folks supplement with a goal of enhancing autophagy. To wit:Acipimox

An orally active xenobiotic

nicotinic acid analogue that suppresses lipolysis and the release of

free fatty acids (FFAs) into the bloodstream, thereby increasing

autophagic protein recycling in addition to lowering triglyceride and

VLDL.On Mon, Sep 1, 2008 at 9:18 PM, Francesca Skelton <fskelton@...> wrote:

and : please explain this in lay language.

Thanks in advance.

From: Dowling <christopher.a.dowling@...>

Reply-< >

Date: Mon, 1 Sep 2008 20:31:55 -0400

< >

Subject: Re: [ ] Re: Has Anyone heard of this?

Yes. Some people supplement with certain substances to enhance autophagy as well.

On Mon, Sep 1, 2008 at 5:18 PM, Séguin <patrickseguin@...> wrote:

This one too:

Autophagy is required for dietary restriction-mediated life span

extension in C. elegans.Jia K, Levine B.

Department of Internal Medicine, University of Texas Southwestern

Medical Center, Dallas, Texas 75390-9113, USA.

Dietary restriction extends life span in diverse species including

Caenorhabditis elegans. However, the downstream cellular targets

regulated by dietary restriction are largely unknown. Autophagy, an

evolutionary conserved lysosomal degradation pathway, is induced

under starvation conditions and regulates life span in insulin

signaling C. elegans mutants. We now report that two essential

autophagy genes (bec-1 and Ce-atg7) are required for the longevity

phenotype of the C. elegans dietary restriction mutant (eat-2(ad1113)

animals. Thus, we propose that autophagy mediates the effect, not

only of insulin signaling, but also of dietary restriction on the

regulation of C. elegans life span. Since autophagy and longevity

control are highly conserved from C. elegans to mammals, a similar

role for autophagy in dietary restriction-mediated life span

extension may also exist in mammals.

PMID: 17912023 [PubMed - indexed for MEDLINE]

>

>

>

>

>

> It seems that autophagy is a key process in extending lifespan of

> Caenorhabditis elegans. One way to increase levels of autophagous

> activity in the body is nutrient starvation. should we be fine-

tuning

> nutrient deficiencies instead of making sure all are supposed needs

> are met.

>

>

>

> 1: Autophagy. 2008 Apr 1;4(3):330-8. Epub 2008 Jan 21. Links

>

> Comment in:

> Autophagy. 2008 Apr 1;4(3):265-7.

> Longevity pathways converge on autophagy genes to regulate life

span

> in Caenorhabditis elegans.Tóth ML, Sigmond T, Borsos E, Barna J,

> Erdélyi P, Takács-Vellai K, Orosz L, Kovács AL, Csikós G, Sass M,

> Vellai T.

> Department of Genetics, Eötvös Loránd University, Budapest, Hungary.

>

> Aging is a multifactorial process with many mechanisms contributing

> to the decline. Mutations decreasing insulin/IGF-1 (insulin-like

> growth factor-1) or TOR (target of rapamycin) kinase-mediated

> signaling, mitochondrial activity and food intake each extend life

> span in divergent animal phyla. Understanding how these genetically

> distinct mechanisms interact to control longevity is a fundamental

> and fascinating problem in biology. Here we show that mutational

> inactivation of autophagy genes, which are involved in the

> degradation of aberrant, damaged cytoplasmic constituents

> accumulating in all aging cells, accelerates the rate at which the

> tissues age in the nematode Caenorhabditis elegans. According to

our

> results Drosophila flies deficient in autophagy are also short-

lived.

> We further demonstrate that reduced activity of autophagy genes

> suppresses life span extension in mutant nematodes with inherent

> dietary restriction, aberrant insulin/IGF-1 or TOR signaling, and

> lowered mitochondrial respiration. These findings suggest that the

> autophagy gene cascade functions downstream of and is inhibited by

> different longevity pathways in C. elegans, therefore, their

effects

> converge on autophagy genes to slow down aging and lengthen life

> span. Thus, autophagy may act as a central regulatory mechanism of

> animal aging.

>

> PMID: 18219227 [PubMed - indexed for MEDLINE]

>

> Autophagy occurs at a basal level in normal growing conditions;

> however, certain types of environmental stress result in a dramatic

> induction. For example, yeast autophagy is induced by nutrient

> starvation, including nitrogen and carbon depletion.

>

> http://www.nature.com/cdd/journal/v12/n2s/full/4401765a.html

>

[Guest guest]

These substances would then have a cr effect? who knew! Why do people

take them generally? to treat some condition? In my original post I

only wished to give experession to my surprise and emphasize that it

semms this cr effect has been very recently noted. i mean that's a

pretty bold title, isn't it?: Longevity pathways converge on

autophagy genes to regulate life span. If this was never discussed

here, we must have been all dozing...

> > >

> > >

> > >

> > >

> > >

> > > It seems that autophagy is a key process in extending lifespan

of

> > > Caenorhabditis elegans. One way to increase levels of

autophagous

> > > activity in the body is nutrient starvation. should we be fine-

> > tuning

> > > nutrient deficiencies instead of making sure all are supposed

needs

> > > are met.

> > >

> > >

> > >

> > > 1: Autophagy. 2008 Apr 1;4(3):330-8. Epub 2008 Jan 21. Links

> > >

> > > Comment in:

> > > Autophagy. 2008 Apr 1;4(3):265-7.

> > > Longevity pathways converge on autophagy genes to regulate life

> > span

> > > in Caenorhabditis elegans.Tóth ML, Sigmond T, Borsos E, Barna J,

> > > Erdélyi P, Takács-Vellai K, Orosz L, Kovács AL, Csikós G, Sass

M,

> > > Vellai T.

> > > Department of Genetics, Eötvös Loránd University, Budapest,

Hungary.

> > >

> > > Aging is a multifactorial process with many mechanisms

contributing

> > > to the decline. Mutations decreasing insulin/IGF-1 (insulin-like

> > > growth factor-1) or TOR (target of rapamycin) kinase-mediated

> > > signaling, mitochondrial activity and food intake each extend

life

> > > span in divergent animal phyla. Understanding how these

genetically

> > > distinct mechanisms interact to control longevity is a

fundamental

> > > and fascinating problem in biology. Here we show that mutational

> > > inactivation of autophagy genes, which are involved in the

> > > degradation of aberrant, damaged cytoplasmic constituents

> > > accumulating in all aging cells, accelerates the rate at which

the

> > > tissues age in the nematode Caenorhabditis elegans. According to

> > our

> > > results Drosophila flies deficient in autophagy are also short-

> > lived.

> > > We further demonstrate that reduced activity of autophagy genes

> > > suppresses life span extension in mutant nematodes with inherent

> > > dietary restriction, aberrant insulin/IGF-1 or TOR signaling,

and

> > > lowered mitochondrial respiration. These findings suggest that

the

> > > autophagy gene cascade functions downstream of and is inhibited

by

> > > different longevity pathways in C. elegans, therefore, their

> > effects

> > > converge on autophagy genes to slow down aging and lengthen life

> > > span. Thus, autophagy may act as a central regulatory mechanism

of

> > > animal aging.

> > >

> > > PMID: 18219227 [PubMed - indexed for MEDLINE]

> > >

> > > Autophagy occurs at a basal level in normal growing conditions;

> > > however, certain types of environmental stress result in a

dramatic

> > > induction. For example, yeast autophagy is induced by nutrient

> > > starvation, including nitrogen and carbon depletion.

> > >

> > > http://www.nature.com/cdd/journal/v12/n2s/full/4401765a.html

> > >

> >

> >

> >

>

[Guest guest]

Some people think supplementation can be more helpful; other folks may be more skeptical. I would not say you've been sleeping, but, perhaps, less focused upon the latest potential means of possibly enhancing CR. Many grains of salt recommended.