Re: Can Fasting Blunt Chemotherapy's Debilitating Side Effects?

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Diane wrote:

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CANCER RESEARCH: Can Fasting Blunt Chemotherapy's Debilitating Side Effects? CouzinScience 29 August 2008: 1146-1147.Summary: A dramatic experiment in mice has led some researchers to suggest that fasting may blunt the side effects of cancer treatment and perhaps even allow patients to tolerate higher drug doses.

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Fasting is found to reduce chemo side-effects. The pdf of the paper is availed.http://www.reuters.com/article/domesticNews/idUSN0122068920080401?sp=truehttp://tinyurl.com/5c9prxReactive Oxygen Species Special Feature - Research Articles - Biological Sciences - Medical Sciences:Lizzia Raffaghello, Changhan Lee, M. Safdie, Min Wei, Federica Madia, Giovanna Bianchi, and Valter D. Longo>From the Cover: Reactive Oxygen Species Special Feature: Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapyPNAS 2008 105:8215-8220; published ahead of print March 31, 2AbstractStrategies to treat cancer have focused primarily on the killing of tumor cells.Here, we describe a differential stress

resistance (DSR) method that focuses instead on protecting the organism but not cancer cells against chemotherapy.Short-term starved S. cerevisiae or cells lacking proto-oncogene homologs were up to 1,000 times better protected against oxidative stress or chemotherapy drugs than cells expressing the oncogene homolog Ras2val19. Low-glucose or low-serum media also protected primary glial cells but not six different rat and human glioma and neuroblastoma cancer cell lines against hydrogen peroxide or the chemotherapy drug/pro-oxidant cyclophosphamide. Finally, short-term starvation provided complete protection to mice but not to injected neuroblastoma cells against a high dose of the chemotherapy drug/pro-oxidant etoposide.These studies describe a starvation-based DSR strategy to enhance the efficacy of chemotherapy and suggest that specific agents among those that promote oxidative stress and DNA damage have the potential to maximize the

differential toxicity to normal and cancer cells.Keywords: reactive oxygen species short-term starvation maintenance mode-- Al Pater