Modified alternate-day fasting regimens vs daily CR

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In summary, modified ADF, allowing the consumption of 15% of energy

needs on the restricted intake day, decreases global cell

proliferation similarly as true ADF and daily CR without reducing body

weight.

I don't know how many CRON's fast but occasionally I fast ~24hrs maybe

several times per month at most. Nothing deliberate just due to my

schedule. Anyone here deliberately use 'fasting' as part of their CRON

regimen?

FASEB J. 2008 Jan 9 [Epub ahead of print]Click here to read Links

Modified alternate-day fasting regimens reduce cell proliferation

rates to a similar extent as daily calorie restriction in mice.

Varady KA, Roohk DJ, McEvoy-Hein BK, Gaylinn BD, Thorner MO,

Hellerstein MK.

*Department of Nutritional Sciences and Toxicology, University of

California at Berkeley, Berkeley, California, USA; andDivision of

Endocrinology and Metabolism, Department of Internal Medicine,

University of Virginia, Charlottesville, Virginia, USA.

Calorie restriction (CR) and alternate-day fasting (ADF) reduce

cancer risk and reduce cell proliferation rates. Whether modified ADF

regimens (i.e., allowing a portion of energy needs to be consumed on

the fast day) work, as well as true ADF or CR to reduce global cell

proliferation rates, remains unresolved. Here, we measured the effects

of true ADF, modified ADF, and daily CR on cell proliferation rates in

mice. Thirty female C57BL/6J mice were randomized to one of five

interventions for 4 wk: 1) CR-25% (25% reduction in daily energy

intake), 2) ADF-75% (75% reduction on fast day), 3) ADF-85% (85%

reduction on fast day), 4) ADF-100% (100% reduction on fast day), and

5) control (ad libitum intake). Body weights of the ADF groups did not

differ from controls, whereas the CR-25% group weighed less than all

other groups posttreatment. Epidermal cell proliferation decreased

(P<0.01) by 29, 20, and 31% in the CR-25%, ADF-85% and ADF-100%

groups, respectively, relative to controls. Proliferation rates of

splenic T cells were reduced (P<0.01) by 37, 32, and 31% in the

CR-25%, ADF-85%, and ADF-100% groups, respectively, and mammary

epithelial cell proliferation was 70, 65, and 62% lower (P<0.01),

compared with controls. Insulin-like growth factor-1 levels were

reduced (P<0.05) in the CR-25% and ADF-100% groups only. In summary,

modified ADF, allowing the consumption of 15% of energy needs on the

restricted intake day, decreases global cell proliferation similarly

as true ADF and daily CR without reducing body weight.-Varady, K. A.,

Roohk, D. J., McEvoy-Hein, B. K., Gaylinn, B. D., Thorner, M. O.,

Hellersteinm M. K. Modified alternate-day fasting regimens reduce cell

proliferation rates to a similar extent as daily calorie restriction

in mice.

PMID: 18184721 [PubMed - as supplied by publisher]