For every 10-g/d increase in saturated fat intake, IMT was 0.03 mm higher...

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Results: For every 10-g/d increase in saturated fat intake, IMT was

0.03 mm higher (P = 0.01) after multivariate adjustment. A 1-g/d

higher intake of trans fat was associated with a 0.03-mm higher IMT (P

= 0.02) after multivariate adjustment. The ratio of polyunsaturated to

saturated fat (P:S) was inversely associated with IMT after

multivariate adjustment (change in IMT: –0.06 mm; P < 0.01). Saturated

and trans fat intakes were independently associated with IMT thickness

(change in IMT: 0.03 mm; P < 0.01 and 0.02, respectively; P for

interaction = 0.01). Polyunsaturated, monounsaturated, cholesterol,

and total fat intakes were unrelated to IMT. The relation between

saturated fat intake and IMT strengthened ( & #946; = 0.0066, P < 0.001) in

persons who never or rarely consumed alcohol as compared with moderate

or heavy drinkers ( & #946; = 0.0001, P = 0.79, P for interaction = 0.01).

Interrelation of saturated fat, trans fat, alcohol intake, and

subclinical atherosclerosis1,2,3

Anwar T Merchant, E Kelemen, Lawrence de Koning, Eva Lonn, Vlad

Vuksan, Ruby s, Bonnie , Koon K Teo, Salim Yusuf, S

Anand for the SHARE and SHARE-AP investigators

1 From the Population Health Research Institute, Hamilton, Canada

(ATM, LdK, EL, RJ, BD, KKT, SY, and SSA); McMaster University,

Hamilton, Canada (ATM, LdK, KKT, SY, and SSA); Hamilton Health

Sciences, Hamilton, Canada (EL, KKT, SY, and SSA); the Alberta Cancer

Board, Calgary, Canada (LEK); the University of Toronto, Toronto,

Canada (VV); and Six Nations Health Services, Ohsweken, Canada (RJ and BD)

Background: Intake of saturated fat, trans fat, and alcohol alter

cardiovascular disease risk, but their effect on subclinical

atherosclerosis remains understudied.

Objective: The objective was to examine and quantify the interrelation

of saturated fat, trans fat, alcohol intake, and mean carotid artery

intimal medial thickness (IMT).

Design: We conducted a population-based, cross-sectional study among

620 persons of Aboriginal, South Asian, Chinese, or European origin

aged 35–75 y, who had lived in Canada for & #8805;5 y. Mean IMT was

calculated from 6 well-defined segments of the right and left carotid

arteries with standardized B-mode ultrasound, and saturated fat, trans

fat, and alcohol intakes were measured with validated food-frequency

questionnaires.

Results: For every 10-g/d increase in saturated fat intake, IMT was

0.03 mm higher (P = 0.01) after multivariate adjustment. A 1-g/d

higher intake of trans fat was associated with a 0.03-mm higher IMT (P

= 0.02) after multivariate adjustment. The ratio of polyunsaturated to

saturated fat (P:S) was inversely associated with IMT after

multivariate adjustment (change in IMT: –0.06 mm; P < 0.01). Saturated

and trans fat intakes were independently associated with IMT thickness

(change in IMT: 0.03 mm; P < 0.01 and 0.02, respectively; P for

interaction = 0.01). Polyunsaturated, monounsaturated, cholesterol,

and total fat intakes were unrelated to IMT. The relation between

saturated fat intake and IMT strengthened ( & #946; = 0.0066, P < 0.001) in

persons who never or rarely consumed alcohol as compared with moderate

or heavy drinkers ( & #946; = 0.0001, P = 0.79, P for interaction = 0.01).

Conclusion: Higher habitual intakes of saturated and trans fats are

independently associated with increased subclinical atherosclerosis,

and alcohol intake may attenuate the relation between saturated fat

and subclinical atherosclerosis.

Key Words: Saturated fatty acids • trans fatty acids • alcohol •

carotid atherosclerosis • ethnicity

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Thanks, But, I didn't see the citation listed so here it is..American Journal of Clinical Nutrition, Vol. 87, No. 1, 168-174, January 2008Jeff On Jan 17, 2008, at 9:20 AM, bill4cr wrote:Results: For every 10-g/d increase in saturated fat intake, IMT was0.03 mm higher (P = 0.01) after multivariate adjustment. A 1-g/dhigher intake of trans fat was associated with a 0.03-mm higher IMT (P= 0.02) after multivariate adjustment. The ratio of polyunsaturated tosaturated fat (P:S) was inversely associated with IMT aftermultivariate adjustment (change in IMT: –0.06 mm; P < 0.01). Saturatedand trans fat intakes were independently associated with IMT thickness(change in IMT: 0.03 mm; P < 0.01 and 0.02, respectively; P forinteraction = 0.01). Polyunsaturated, monounsaturated, cholesterol,and total fat intakes were unrelated to IMT. The relation betweensaturated fat intake and IMT strengthened ( & #946; = 0.0066, P < 0.001) inpersons who never or rarely consumed alcohol as compared with moderateor heavy drinkers ( & #946; = 0.0001, P = 0.79, P for interaction = 0.01).Interrelation of saturated fat, trans fat, alcohol intake, andsubclinical atherosclerosis1,2,3Anwar T Merchant, E Kelemen, Lawrence de Koning, Eva Lonn, VladVuksan, Ruby s, Bonnie , Koon K Teo, Salim Yusuf, SAnand for the SHARE and SHARE-AP investigators1 From the Population Health Research Institute, Hamilton, Canada(ATM, LdK, EL, RJ, BD, KKT, SY, and SSA); McMaster University,Hamilton, Canada (ATM, LdK, KKT, SY, and SSA); Hamilton HealthSciences, Hamilton, Canada (EL, KKT, SY, and SSA); the Alberta CancerBoard, Calgary, Canada (LEK); the University of Toronto, Toronto,Canada (VV); and Six Nations Health Services, Ohsweken, Canada (RJ and BD)Background: Intake of saturated fat, trans fat, and alcohol altercardiovascular disease risk, but their effect on subclinicalatherosclerosis remains understudied.Objective: The objective was to examine and quantify the interrelationof saturated fat, trans fat, alcohol intake, and mean carotid arteryintimal medial thickness (IMT).Design: We conducted a population-based, cross-sectional study among620 persons of Aboriginal, South Asian, Chinese, or European originaged 35–75 y, who had lived in Canada for & #8805;5 y. Mean IMT wascalculated from 6 well-defined segments of the right and left carotidarteries with standardized B-mode ultrasound, and saturated fat, transfat, and alcohol intakes were measured with validated food-frequencyquestionnaires.Results: For every 10-g/d increase in saturated fat intake, IMT was0.03 mm higher (P = 0.01) after multivariate adjustment. A 1-g/dhigher intake of trans fat was associated with a 0.03-mm higher IMT (P= 0.02) after multivariate adjustment. The ratio of polyunsaturated tosaturated fat (P:S) was inversely associated with IMT aftermultivariate adjustment (change in IMT: –0.06 mm; P < 0.01). Saturatedand trans fat intakes were independently associated with IMT thickness(change in IMT: 0.03 mm; P < 0.01 and 0.02, respectively; P forinteraction = 0.01). Polyunsaturated, monounsaturated, cholesterol,and total fat intakes were unrelated to IMT. The relation betweensaturated fat intake and IMT strengthened ( & #946; = 0.0066, P < 0.001) inpersons who never or rarely consumed alcohol as compared with moderateor heavy drinkers ( & #946; = 0.0001, P = 0.79, P for interaction = 0.01).Conclusion: Higher habitual intakes of saturated and trans fats areindependently associated with increased subclinical atherosclerosis,and alcohol intake may attenuate the relation between saturated fatand subclinical atherosclerosis.Key Words: Saturated fatty acids • trans fatty acids • alcohol •carotid atherosclerosis • ethnicity

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Hi folks:

So it looks like trans fats are ten times worse than saturated fats?

Rodney.

> > > Results: For every 10-g/d increase in saturated fat intake, IMT was> > 0.03 mm higher (P = 0.01) after multivariate adjustment. A 1-g/d> > higher intake of trans fat was associated with a 0.03-mm higher IMT (P> > = 0.02) after multivariate adjustment. The ratio of polyunsaturated to> > saturated fat (P:S) was inversely associated with IMT after> > multivariate adjustment (change in IMT: –0.06 mm; P < 0.01). Saturated> > and trans fat intakes were independently associated with IMT thickness> > (change in IMT: 0.03 mm; P < 0.01 and 0.02, respectively; P for> > interaction = 0.01). Polyunsaturated, monounsaturated, cholesterol,> > and total fat intakes were unrelated to IMT. The relation between> > saturated fat intake and IMT strengthened ( & #946; = 0.0066, P < > > 0.001) in> > persons who never or rarely consumed alcohol as compared with moderate> > or heavy drinkers ( & #946; = 0.0001, P = 0.79, P for interaction = > > 0.01).> >> > Interrelation of saturated fat, trans fat, alcohol intake, and> > subclinical atherosclerosis1,2,3> > Anwar T Merchant, E Kelemen, Lawrence de Koning, Eva Lonn, Vlad> > Vuksan, Ruby s, Bonnie , Koon K Teo, Salim Yusuf, S> > Anand for the SHARE and SHARE-AP investigators> >> > 1 From the Population Health Research Institute, Hamilton, Canada> > (ATM, LdK, EL, RJ, BD, KKT, SY, and SSA); McMaster University,> > Hamilton, Canada (ATM, LdK, KKT, SY, and SSA); Hamilton Health> > Sciences, Hamilton, Canada (EL, KKT, SY, and SSA); the Alberta Cancer> > Board, Calgary, Canada (LEK); the University of Toronto, Toronto,> > Canada (VV); and Six Nations Health Services, Ohsweken, Canada (RJ > > and BD)> >> > Background: Intake of saturated fat, trans fat, and alcohol alter> > cardiovascular disease risk, but their effect on subclinical> > atherosclerosis remains understudied.> >> > Objective: The objective was to examine and quantify the interrelation> > of saturated fat, trans fat, alcohol intake, and mean carotid artery> > intimal medial thickness (IMT).> >> > Design: We conducted a population-based, cross-sectional study among> > 620 persons of Aboriginal, South Asian, Chinese, or European origin> > aged 35–75 y, who had lived in Canada for & #8805;5 y. Mean IMT was> > calculated from 6 well-defined segments of the right and left carotid> > arteries with standardized B-mode ultrasound, and saturated fat, trans> > fat, and alcohol intakes were measured with validated food-frequency> > questionnaires.> >> > Results: For every 10-g/d increase in saturated fat intake, IMT was> > 0.03 mm higher (P = 0.01) after multivariate adjustment. A 1-g/d> > higher intake of trans fat was associated with a 0.03-mm higher IMT (P> > = 0.02) after multivariate adjustment. The ratio of polyunsaturated to> > saturated fat (P:S) was inversely associated with IMT after> > multivariate adjustment (change in IMT: –0.06 mm; P < 0.01). Saturated> > and trans fat intakes were independently associated with IMT thickness> > (change in IMT: 0.03 mm; P < 0.01 and 0.02, respectively; P for> > interaction = 0.01). Polyunsaturated, monounsaturated, cholesterol,> > and total fat intakes were unrelated to IMT. The relation between> > saturated fat intake and IMT strengthened ( & #946; = 0.0066, P < > > 0.001) in> > persons who never or rarely consumed alcohol as compared with moderate> > or heavy drinkers ( & #946; = 0.0001, P = 0.79, P for interaction = > > 0.01).> >> > Conclusion: Higher habitual intakes of saturated and trans fats are> > independently associated with increased subclinical atherosclerosis,> > and alcohol intake may attenuate the relation between saturated fat> > and subclinical atherosclerosis.> >> > Key Words: Saturated fatty acids • trans fatty acids • alcohol •> > carotid atherosclerosis • ethnicity> >> >> >>

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Hi JR:

Just to make clear the point of my post. I have wondered for some time how much more dangerous trans fats are compared with 'regular' saturated fats, which most of us avoid as we would the plague.

With that in mind I was reading the quoted section from the journal article which said:

"Results: For every 10-g/d increase in saturated fat intake, IMT was 0.03 mm higher ...... A 1-g/d higher intake of trans fat was associated with a 0.03-mm higher IMT....... "

So I concluded that if 1g per day of trans fats clogs the carotid artery to the same extent as 10g per day of saturated fats, then trans fats are, by this criterion, ten times more dangerous.

Like you, I endeavor to eat minimal amounts of either of them. Indeed, in my case most other kinds of fats also, the major exceptions being those from nuts and fish.

Rodney.> > Hi folks:> > So it looks like trans fats are ten times worse than saturated fats?> >> > Rodney.