Re: Study shows how broccoli prevents cancer

[Guest guest]

Oh oh... doesn't broccoli contain the dreaded Methionine? When I was a kid you couldn't make me eat broccoli, now sometimes 2x a day.Oh well... I'll gamble it's more good than bad.I don't try to micro manage something I don't understand fully.JROn Jul 2, 2008, at 12:52 PM, Diane Walter wrote:I have the full pdf version if anyone wants it:Broccoli Consumption Interacts with GSTM1 to Perturb OncogenicSignalling Pathways in the Prostate Traka1, Amy V. Gasper, Antonietta Melchini1,, R. Bacon1, Change settings via the Web ( ID required) Change settings via email: Switch delivery to Daily Digest | Switch format to Traditional Visit Your Group |  Terms of Use | UnsubscribeRECENT ACTIVITY8New Members2New FilesVisit Your GroupMeditation andLovingkindnessA Groupto share and learn. HealthEarly DetectionKnow the symptomsof breast cancer.New web site?Drive traffic now.Get your businesson search.. 

[Guest guest]

Broccoli sprouts have multiple times the benefit of broccoli. See msg 27146 which says:

" Three-day-old broccoli sprouts consistently contain 20 to 50 times the protective compounds found in broccoli. http://www.hopkinsmedicine.org/press/1997/SEPT/970903.HTM

Also. see post #26214.

Also tomatoes and broccoli eaten together are more potent than broccoli alone. See #24921.

We now have a “cancer” file. Look under CRON Science for the file on cancer.

From: Diane Walter <dianepwalter@...>

Reply-< >

Date: Wed, 02 Jul 2008 17:52:44 -0000

< >

Subject: [ ] Study shows how broccoli prevents cancer

I have the full pdf version if anyone wants it:

Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic

Signalling Pathways in the Prostate

Traka1, Amy V. Gasper, Antonietta Melchini1,, R. Bacon1,

W. Needs1, Frost3, Chantry, andra M. E.

, Catharine A. Ortori, A. Barrett5, Y. Ball6,

D. Mills, F. Mithen1*

Epidemiological studies suggest that people who consume more than one

portion of cruciferous vegetables per week are at lower risk of both

the incidence of prostate cancer and of developing aggressive prostate

cancer but there is little understanding of the underlying mechanisms.

In this study, we quantify and interpret changes in global gene

expression patterns in the human prostate gland before, during and

after a 12 month broccoli-rich diet.

Methods and Findings

Volunteers were randomly assigned to either a broccoli-rich or a

pea-rich diet. After six months there were no differences in gene

expression between glutathione S-transferase mu 1 (GSTM1) positive and

null individuals on the pea-rich diet but significant differences

between GSTM1 genotypes on the broccoli-rich diet, associated with

transforming growth factor beta 1 (TGF & #946;1) and epidermal growth factor

(EGF) signalling pathways. Comparison of biopsies obtained pre and

post intervention revealed more changes in gene expression occurred in

individuals on a broccoli-rich diet than in those on a pea-rich diet.

While there were changes in androgen signalling, regardless of diet,

men on the broccoli diet had additional changes to mRNA processing,

and TGF & #946;1, EGF and insulin signalling. We also provide evidence that

sulforaphane (the isothiocyanate derived from 4-methylsuphinylbutyl

glucosinolate that accumulates in broccoli) chemically interacts with

TGF & #946;1, EGF and insulin peptides to form thioureas, and enhances

TGF & #946;1/Smad-mediated transcription.

Conclusions

These findings suggest that consuming broccoli interacts with GSTM1

genotype to result in complex changes to signalling pathways

associated with inflammation and carcinogenesis in the prostate. We

propose that these changes may be mediated through the chemical

interaction of isothiocyanates with signalling peptides in the plasma.

This study provides, for the first time, experimental evidence

obtained in humans to support observational studies that diets rich in

cruciferous vegetables may reduce the risk of prostate cancer and

other chronic disease.

Diane

[Guest guest]

Hi folks:

As regards the methionine content of broccoli and tomato - suggested by Francesca - if you eat one pound of broccoli with one pound of crushed tomatoes, the methionine content would be only 0.23 grams.

Plenty of room for some other sources of MET without going over one gram in total. Especially if fruits are included, many of which have a near-negligible MET content. MET is an essential nutrient. So no one is suggesting, I hope, that it be eliminated entirely.

Rodney.

>> Broccoli sprouts have multiple times the benefit of broccoli. See msg 27146> which says:> > "Three-day-old broccoli sprouts consistently contain 20 to 50 times the> protective compounds found in broccoli.> http://www.hopkinsmedicine.org/press/1997/SEPT/970903.HTM> > Also. see post #26214.> > Also tomatoes and broccoli eaten together are more potent than broccoli> alone. See #24921.> > We now have a ³cancer² file. Look under CRON Science for the file on cancer.> > > > From: Diane Walter dianepwalter@...> Reply- > Date: Wed, 02 Jul 2008 17:52:44 -0000> > Subject: [ ] Study shows how broccoli prevents cancer> > > > > I have the full pdf version if anyone wants it:> > Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic> Signalling Pathways in the Prostate> > Traka1, Amy V. Gasper, Antonietta Melchini1,, R. Bacon1,> W. Needs1, Frost3, Chantry, andra M. E.> , Catharine A. Ortori, A. Barrett5, Y. Ball6,> D. Mills, F. Mithen1*> > Epidemiological studies suggest that people who consume more than one> portion of cruciferous vegetables per week are at lower risk of both> the incidence of prostate cancer and of developing aggressive prostate> cancer but there is little understanding of the underlying mechanisms.> In this study, we quantify and interpret changes in global gene> expression patterns in the human prostate gland before, during and> after a 12 month broccoli-rich diet.> Methods and Findings> > Volunteers were randomly assigned to either a broccoli-rich or a> pea-rich diet. After six months there were no differences in gene> expression between glutathione S-transferase mu 1 (GSTM1) positive and> null individuals on the pea-rich diet but significant differences> between GSTM1 genotypes on the broccoli-rich diet, associated with> transforming growth factor beta 1 (TGF & #946;1) and epidermal growth factor> (EGF) signalling pathways. Comparison of biopsies obtained pre and> post intervention revealed more changes in gene expression occurred in> individuals on a broccoli-rich diet than in those on a pea-rich diet.> While there were changes in androgen signalling, regardless of diet,> men on the broccoli diet had additional changes to mRNA processing,> and TGF & #946;1, EGF and insulin signalling. We also provide evidence that> sulforaphane (the isothiocyanate derived from 4-methylsuphinylbutyl> glucosinolate that accumulates in broccoli) chemically interacts with> TGF & #946;1, EGF and insulin peptides to form thioureas, and enhances> TGF & #946;1/Smad-mediated transcription.> Conclusions> > These findings suggest that consuming broccoli interacts with GSTM1> genotype to result in complex changes to signalling pathways> associated with inflammation and carcinogenesis in the prostate. We> propose that these changes may be mediated through the chemical> interaction of isothiocyanates with signalling peptides in the plasma.> This study provides, for the first time, experimental evidence> obtained in humans to support observational studies that diets rich in> cruciferous vegetables may reduce the risk of prostate cancer and> other chronic disease.> > Diane>

[Guest guest]

Hi folks:

It would be nice to know the sulphorapane content per 100 calories for all these different foods. Does anyone have a source for that?

If the "20 to 50 times more" means per unit weight then it still means a lot of sprouts it seems to me. But it doesn't specify the units.

How much of this is 'enough', I wonder?

Rodney.

>> Broccoli sprouts have multiple times the benefit of broccoli. See msg 27146> which says:> > "Three-day-old broccoli sprouts consistently contain 20 to 50 times the> protective compounds found in broccoli.> http://www.hopkinsmedicine.org/press/1997/SEPT/970903.HTM> > Also. see post #26214.> > Also tomatoes and broccoli eaten together are more potent than broccoli> alone. See #24921.> > We now have a ³cancer² file. Look under CRON Science for the file on cancer.> > > > From: Diane Walter dianepwalter@...> Reply- > Date: Wed, 02 Jul 2008 17:52:44 -0000> > Subject: [ ] Study shows how broccoli prevents cancer> > > > > I have the full pdf version if anyone wants it:> > Broccoli Consumption Interacts with GSTM1 to Perturb Oncogenic> Signalling Pathways in the Prostate> > Traka1, Amy V. Gasper, Antonietta Melchini1,, R. Bacon1,> W. Needs1, Frost3, Chantry, andra M. E.> , Catharine A. Ortori, A. Barrett5, Y. Ball6,> D. Mills, F. Mithen1*> > Epidemiological studies suggest that people who consume more than one> portion of cruciferous vegetables per week are at lower risk of both> the incidence of prostate cancer and of developing aggressive prostate> cancer but there is little understanding of the underlying mechanisms.> In this study, we quantify and interpret changes in global gene> expression patterns in the human prostate gland before, during and> after a 12 month broccoli-rich diet.> Methods and Findings> > Volunteers were randomly assigned to either a broccoli-rich or a> pea-rich diet. After six months there were no differences in gene> expression between glutathione S-transferase mu 1 (GSTM1) positive and> null individuals on the pea-rich diet but significant differences> between GSTM1 genotypes on the broccoli-rich diet, associated with> transforming growth factor beta 1 (TGF & #946;1) and epidermal growth factor> (EGF) signalling pathways. Comparison of biopsies obtained pre and> post intervention revealed more changes in gene expression occurred in> individuals on a broccoli-rich diet than in those on a pea-rich diet.> While there were changes in androgen signalling, regardless of diet,> men on the broccoli diet had additional changes to mRNA processing,> and TGF & #946;1, EGF and insulin signalling. We also provide evidence that> sulforaphane (the isothiocyanate derived from 4-methylsuphinylbutyl> glucosinolate that accumulates in broccoli) chemically interacts with> TGF & #946;1, EGF and insulin peptides to form thioureas, and enhances> TGF & #946;1/Smad-mediated transcription.> Conclusions> > These findings suggest that consuming broccoli interacts with GSTM1> genotype to result in complex changes to signalling pathways> associated with inflammation and carcinogenesis in the prostate. We> propose that these changes may be mediated through the chemical> interaction of isothiocyanates with signalling peptides in the plasma.> This study provides, for the first time, experimental evidence> obtained in humans to support observational studies that diets rich in> cruciferous vegetables may reduce the risk of prostate cancer and> other chronic disease.> > Diane>