Re: Low vit D linked to cardiovascular disease

[Guest guest]

Hi folks:

This is kind of interesting regarding vitamin D levels.

It also, conveniently, provides the conversion factor for ng/ml to

nmol/L, which is, it says:

" Conversion factor for serum 25(OH)D: 1 nmol/liter = 0.40 ng/ml. "

http://edrv.endojournals.org/cgi/content/full/22/4/477/T1

Rodney.

>

> Study found that 28% of subjects had blood levels of 25(OH)D lower

> than 15 nanograms per millilitre (ng/mL). Over 5.4 years, people

with

> the lower vitamin D levels were 62 per cent more likely to develop

a

> cardiovascular event than people with 25(OH)D levels over 15 ng/mL.

>

> Levels above 30 ng/mL are considered optimal for bone metabolism,

only

> 10 per cent of the participants had levels in this range.

>

>

> +++++++++++++++++++++++++++

>

> Link:

>

> http://www.nutraingredients-usa.com/news/ng.asp?

n=82380 & m=1NIU108 & c=lqeudkujayvvlpc

>

>

> Full text:

>

> Low vitamin D levels linked to increased heart disease risk

>

> By ls

> 1/8/2008- Low levels of vitamin D could increase the risk of

> cardiovascular events like heart attack, heart failure or stroke

by 62

> per cent, suggests a new study from the US.

>

> And the outlook could be even worse for those with high blood

pressure

> and low blood levels of vitamin with a doubling of the risk, report

> researchers in the journal Circulation - the Journal of the

American

> Heart Association.

>

> " The possibility of a causal link between vitamin D deficiency and

> cardiovascular disease is supported by biological plausibility, the

> demonstration of a temporal association, and the finding of a dose

> response between 25-OH D deficiency and risk, " wrote lead author

> Wang from Harvard Medical School.

>

> " These data raise the possibility that treatment of vitamin D

> deficiency, via supplementation or lifestyle measures, could reduce

> cardiovascular risk. "

>

> Interest in vitamin D has been increasing in recent months with an

> increasing number of studies linking the vitamin to protection

against

> osteoporosis and certain cancers. There is also evidence that a

higher

> intake of vitamin D may be helpful in preventing and treating high

> blood pressure, fibromyalgia, diabetes mellitus, multiple sclerosis

> and rheumatoid arthritis.

>

> The researchers used data from the 1739 participants in the

Framingham

> Offspring Study (average age 59 years, 55 per cent women, all

> Caucasian). None of the subjects had any heart health problems at

the

> start of the study and the researchers used blood samples to

measure

> levels of the 'storage' form of the vitamin, 25-dihydroxyvitamin D

> (25(OH)D).

>

> Wang and co-workers found that 28 per cent of subjects had blood

> levels of 25(OH)D lower than 15 nanograms per millilitre (ng/mL).

Over

> 5.4 years of follow-up, 120 people developed a cardiovascular

event,

> and people with the lower vitamin D levels were 62 per cent more

> likely to develop these events than people with 25(OH)D levels

over 15

> ng/mL.

>

> Although levels above 30 ng/mL are considered optimal for bone

> metabolism, only 10 per cent of the participants had levels in

this range.

>

> People with low vitamin D levels and high blood pressure

> (hypertension), defined as having a systolic and diastolic blood

> pressure (BP) greater than 140 and 90 mmHg, were at an increased

risk,

> were found to be at a 113 per cent increased risk than those with

> normal blood pressure and higher vitamin D levels.

>

> " We found that people with low vitamin D levels had a higher rate

of

> cardiovascular events over the five-year follow-up period, " said

Wang.

> " These results are intriguing and suggestive but need to be

followed

> up with further study. "

>

> " Vitamin D receptors have a broad tissue distribution that includes

> vascular smooth muscle and endothelium, the inner lining of the

body's

> vessels, " he added. " Our data raise the possibility that treating

> vitamin D deficiency, via supplementation or lifestyle measures,

could

> reduce cardiovascular risk.

>

> " What hasn't been proven yet is that vitamin D deficiency actually

> causes increased risk of cardiovascular disease. This would

require a

> large randomized trial to show whether correcting the vitamin D

> deficiency would result in a reduction in cardiovascular risk. "

>

> Calls for raising the recommended daily allowance (RDA) of the

vitamin

> have been growing after reports that higher intakes could protect

> against osteoporosis and certain cancers. Consumer awareness of

these

> health links is also increasing with some outlets reporting massive

> boosts in sales.

>

> Vitamin D refers to two biologically inactive precursors - D3, also

> known as cholecalciferol, and D2, also known as ergocalciferol. The

> former is produced in the skin on exposure to UVB radiation (290 to

> 320 nm). The latter is derived from plants and only enters the body

> via the diet, from consumption of foods such as oily fish, egg yolk

> and liver.

>

> Recent studies have shown, however, that sunshine levels in some

> northern countries are so weak during the winter months that the

body

> makes no vitamin D at all, leading some to estimate that over half

of

> the population in such countries have insufficient or deficient

levels

> of the vitamin.

>

> Moreover, increased skin pigmentation also reduces the effect of

UVB

> radiation meaning darker skinned people are more at risk.

>

> " The findings [of the new study] may have potentially broad public

> health implications, given the high prevalence of vitamin D

deficiency

> in developed countries, the contribution of lifestyle and

geography to

> vitamin D status, and the ease, safety, and low cost of treating

> vitamin D deficiency, " concluded the researchers.

>

> Both D3 and D2 precursors are hydroxylated in the liver and

kidneys to

> form 25- hydroxyvitamin D (25(OH)D), the non-active 'storage' form,

> and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active

form

> that is tightly controlled by the body.

>

> Source: Circulation

> January 2008, doi:10.1161/CIRCULATIONAHA.107.706127

> " Vitamin D Deficiency and Risk of Cardiovascular Disease "

> Authors: T.J. Wang, M.J. Pencina, S.L. Booth, P.F. Jacques, E.

> Ingelsson, K. Lanier, E.J. , R.B. D'Agostino, M. Wolf,

R.S. Vasan

>

[Guest guest]

Hi folks:

In addition the ideal range of 25(OH)D around here has very recently

been raised to: 76 - 250 nmol/L.

That is 30·4 - 100 ng/ml, I think. So 30 ng/ml is the ***extreme

low end*** of the reference range here.

AND MY VERY RECENT PERSONAL EXPERIENCE TELLS ME UNEQUIVOCALLY THAT

30.4 ng/ml IS TOTALLY INADEQUATE FOR MY BONE HEALTH ..... an issue

about which I will elaborate in much more detail when my present

ongoing experiment is completed in a few months. But I already have

more than enough data to support, to my satisfaction, the

capitalized wording above.

Rodney.

> >

> > Study found that 28% of subjects had blood levels of 25(OH)D

lower

> > than 15 nanograms per millilitre (ng/mL). Over 5.4 years, people

> with

> > the lower vitamin D levels were 62 per cent more likely to

develop

> a

> > cardiovascular event than people with 25(OH)D levels over 15

ng/mL.

> >

> > Levels above 30 ng/mL are considered optimal for bone

metabolism,

> only

> > 10 per cent of the participants had levels in this range.

> >

> >

> > +++++++++++++++++++++++++++

> >

> > Link:

> >

> > http://www.nutraingredients-usa.com/news/ng.asp?

> n=82380 & m=1NIU108 & c=lqeudkujayvvlpc

> >

> >

> > Full text:

> >

> > Low vitamin D levels linked to increased heart disease risk

> >

> > By ls

> > 1/8/2008- Low levels of vitamin D could increase the risk of

> > cardiovascular events like heart attack, heart failure or stroke

> by 62

> > per cent, suggests a new study from the US.

> >

> > And the outlook could be even worse for those with high blood

> pressure

> > and low blood levels of vitamin with a doubling of the risk,

report

> > researchers in the journal Circulation - the Journal of the

> American

> > Heart Association.

> >

> > " The possibility of a causal link between vitamin D deficiency

and

> > cardiovascular disease is supported by biological plausibility,

the

> > demonstration of a temporal association, and the finding of a

dose

> > response between 25-OH D deficiency and risk, " wrote lead author

> > Wang from Harvard Medical School.

> >

> > " These data raise the possibility that treatment of vitamin D

> > deficiency, via supplementation or lifestyle measures, could

reduce

> > cardiovascular risk. "

> >

> > Interest in vitamin D has been increasing in recent months with

an

> > increasing number of studies linking the vitamin to protection

> against

> > osteoporosis and certain cancers. There is also evidence that a

> higher

> > intake of vitamin D may be helpful in preventing and treating

high

> > blood pressure, fibromyalgia, diabetes mellitus, multiple

sclerosis

> > and rheumatoid arthritis.

> >

> > The researchers used data from the 1739 participants in the

> Framingham

> > Offspring Study (average age 59 years, 55 per cent women, all

> > Caucasian). None of the subjects had any heart health problems

at

> the

> > start of the study and the researchers used blood samples to

> measure

> > levels of the 'storage' form of the vitamin, 25-dihydroxyvitamin

D

> > (25(OH)D).

> >

> > Wang and co-workers found that 28 per cent of subjects had blood

> > levels of 25(OH)D lower than 15 nanograms per millilitre

(ng/mL).

> Over

> > 5.4 years of follow-up, 120 people developed a cardiovascular

> event,

> > and people with the lower vitamin D levels were 62 per cent more

> > likely to develop these events than people with 25(OH)D levels

> over 15

> > ng/mL.

> >

> > Although levels above 30 ng/mL are considered optimal for bone

> > metabolism, only 10 per cent of the participants had levels in

> this range.

> >

> > People with low vitamin D levels and high blood pressure

> > (hypertension), defined as having a systolic and diastolic blood

> > pressure (BP) greater than 140 and 90 mmHg, were at an increased

> risk,

> > were found to be at a 113 per cent increased risk than those with

> > normal blood pressure and higher vitamin D levels.

> >

> > " We found that people with low vitamin D levels had a higher

rate

> of

> > cardiovascular events over the five-year follow-up period, " said

> Wang.

> > " These results are intriguing and suggestive but need to be

> followed

> > up with further study. "

> >

> > " Vitamin D receptors have a broad tissue distribution that

includes

> > vascular smooth muscle and endothelium, the inner lining of the

> body's

> > vessels, " he added. " Our data raise the possibility that treating

> > vitamin D deficiency, via supplementation or lifestyle measures,

> could

> > reduce cardiovascular risk.

> >

> > " What hasn't been proven yet is that vitamin D deficiency

actually

> > causes increased risk of cardiovascular disease. This would

> require a

> > large randomized trial to show whether correcting the vitamin D

> > deficiency would result in a reduction in cardiovascular risk. "

> >

> > Calls for raising the recommended daily allowance (RDA) of the

> vitamin

> > have been growing after reports that higher intakes could protect

> > against osteoporosis and certain cancers. Consumer awareness of

> these

> > health links is also increasing with some outlets reporting

massive

> > boosts in sales.

> >

> > Vitamin D refers to two biologically inactive precursors - D3,

also

> > known as cholecalciferol, and D2, also known as ergocalciferol.

The

> > former is produced in the skin on exposure to UVB radiation (290

to

> > 320 nm). The latter is derived from plants and only enters the

body

> > via the diet, from consumption of foods such as oily fish, egg

yolk

> > and liver.

> >

> > Recent studies have shown, however, that sunshine levels in some

> > northern countries are so weak during the winter months that the

> body

> > makes no vitamin D at all, leading some to estimate that over

half

> of

> > the population in such countries have insufficient or deficient

> levels

> > of the vitamin.

> >

> > Moreover, increased skin pigmentation also reduces the effect of

> UVB

> > radiation meaning darker skinned people are more at risk.

> >

> > " The findings [of the new study] may have potentially broad

public

> > health implications, given the high prevalence of vitamin D

> deficiency

> > in developed countries, the contribution of lifestyle and

> geography to

> > vitamin D status, and the ease, safety, and low cost of treating

> > vitamin D deficiency, " concluded the researchers.

> >

> > Both D3 and D2 precursors are hydroxylated in the liver and

> kidneys to

> > form 25- hydroxyvitamin D (25(OH)D), the non-active 'storage'

form,

> > and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically

active

> form

> > that is tightly controlled by the body.

> >

> > Source: Circulation

> > January 2008, doi:10.1161/CIRCULATIONAHA.107.706127

> > " Vitamin D Deficiency and Risk of Cardiovascular Disease "

> > Authors: T.J. Wang, M.J. Pencina, S.L. Booth, P.F. Jacques, E.

> > Ingelsson, K. Lanier, E.J. , R.B. D'Agostino, M. Wolf,

> R.S. Vasan

> >

>