Red wine polyphenols may reduce effect of fatty food

[Guest guest]

Study investigates impact of red wine polyphenols on levels of

malondialdehyde (MDA), a by-product of fat digestion that is known to

increase the risk of CVD.

A dark turkey meat meal with one tablespoon of concentrated wine added

after cooking, and followed by a glass of wine, reduced MDA absorbtion

by 75%. Adding concentrated wine before cooking had a greater effect.

+++++++++++++++++++

link:

http://www.nutraingredients.com/news/ng.asp?n=82268 & m=1NIE102 & c=lqeudkujayvvlpc

full text:

Wine polyphenols may reduce effect of fatty food: study

By staff reporter

02/01/2008- Polyphenols from wine may reduce the negative impact of

high-fat foods, according to a small study from Israel that suggests a

role in the formulation of healthier food products.

The development of healthier foods to meet the growing concerns of

consumers is a major target for the food industry.

While R & D efforts are currently focused on ingredients and

technologies to reduce fat without impairing taste or texture, the new

findings could point the way to a future where the fat is left in, but

with other ingredients are added to reduce the fat's ill effects.

The researchers, led by ph Kanner of the Department of Food

Science at Volcani Center in Bet Dagan, Israel, acknowledged that

there is existing evidence pointing to the role of polyphenols in

preventing cardiovascular disease, but that the mechanism of action is

not understood.

The aim of their study, published in this month's Journal of the

Federation of American Societies for Experimental Biology (FASEB), was

to look at the impact of red wine polyphenols on levels of

malondialdehyde (MDA), a bi-product of fat digestion that is known to

increase the risk of cardiovascular disease and other conditions.

" We suggested a new hypothesis to explain polyphenols, " said Kanner.

Although the study was small, involving just six healthy men and four

healthy women, he said: " For the first time, these compounds were

demonstrated to prevent significantly the appearance of toxic food

derivative compounds in human plasma. "

Kanner and his team gave the participants one of three different dark

turkey cutlet meals.

The control meal consisted of turkey meat and water; the second

consisted of turkey meat with one tablespoon of concentrated wine

added after cooking and followed by a glass of wine; and the third

meal consisted of the same polyphenols from wine added before cooking,

also followed by a glass of wine.

After the meal, the participants gave blood and urine samples.

Those who ate the control meal were seen to have plasma levels of MDA

increased almost five-fold compared to baseline, by as much as 160 nm

(baseline levels were 30 to 70 nm).

However those who ate the second meal were reported to have a 75 per

cent reduction in absorption of MDA; and in those who ate the third

meal " the elevation of plasma MDA was completely prevented " , wrote the

researchers.

The researchers said the same results were seen from analysis of MDA

accumulation in the participants' urine.

" Our study suggests that red wine polyphenols exert a beneficial

effect by the novel new function, absorption inhibition of the

lipotoxin MDA, " wrote the team.

" These findings explain the potentially harmful effects of oxidised

fats found in foods and the important benefit of dietary polyphenols

in the meal. "

Although the study was very small scale and one would expect

considerably more research to be conducted before the findings had any

real bearing on food industry direction, Gerald Weismann, MD,

editor-in-chief of the FASEB journal, was jubilant about the potential.

" As long as deep fried candy bars are on menus, scientists will need

to keep serving up new ways to prevent the cellular damage caused by

these very tasty treats, " he said.

" This study suggests that the time will come where people can eat

French fries without plugging their arteries. "

Source: The FASEB Journal.

2008, Volume 22, Pages 41-46; doi: 10.1096/fj.07-9041com

" A novel function of red wine polyphenols in humans: prevention of

absorption of cytotoxic lipid peroxidation products "

Authors: S. Gorelik, M. Ligumsky, R. Kohen, J. Kanner