Guest guest Posted August 9, 2008 Report Share Posted August 9, 2008 Hi JW: These also seem to be relevant to the AGEs issue: "A greater than 200-fold increase in AGE immunoreactivity was found after cooking egg whites with fructose (AGE-diet, 1617 ± 348 units AGE/mg), as compared with the CL-diet (7.0 ± 1.6) [without fructose]" from ........ PMID: 9177242 And ................ "A meal rich in AGEs induces acute endothelial and adipocyte dysfunction." From ........ PMID: 18448830 Rodney. >> My focus is brainal diseases so I looked at AGEs and ARMD, probably my worst concern.> Cause of ARMD is unknown but they're looking at possible indicators:> In AMD, activation of the RAGE axis in RPE cells may contribute to upregulation of VEGF, potentially inciting or propagating neovascular macular disease.PMID: 17325184> > > > The choroid is the element back of the retina that fills with stuff, blocking circulation. > > The CML adduct releases TNF alpha which might induce the production and release of VEGF for the abnormal choroidal neovascularization in the patients of age-related macular degeneration. PMID: 17202673> > > This author makes quite positive statements: > Advanced glycation endproduct (AGE) formation is a trigger for the onset of age-related disease. ...> A subset of transcriptional changes is similar to early atherosclerosis, a chronic inflammatory disease characterized by matrix expansion and lipid deposition. These changes suggest an important contribution of a single environmental stimulus to the complex aging response. PMID: 16081535> > > And it's dose dependent: > AGE accumulation, as occurs with normal aging and in disease, may induce receptor-mediated activation of RPE/photoreceptor cells, contributing to disease progression in the aging human retinas. PMID: 15452081> > And:> CONCLUSIONS: These results indicate that glycoxidation products are present in subretinal membranes of patients with ARMD. The concomitant expression of RAGE in these membranes and the finding of activated NFkB is suggestive of an implication of glycoxidation product formation in the pathogenesis of the disease. PMID: 10393061> > So the choroid fills with stuff and starts the first phase which is called "dry" since it's not "bleeding" thru. At some point, the bleeding (wet type) starts and they try to stop it with laser therapy. > ARMD radically changes a person's life.> > The AREDS study put forth a supplement called TOZAL> TOZAL = taurine, omega-3 fatty acids {fish oil}, zinc, antioxidants and lutein.> http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed & pubmedid=17324285> > Table 2> Nutritional supplement formulation> > Component Weight Percent of daily value > Vitamin A (total) 28,640 IU 573% > Vitamin A 10,000 IU > Natural Beta-Carotene 18,640 IU > Vitamin C 452 mg 753% > Vitamin E 200 IU 667% > Zinc Oxide 69.6 mg 464% > Copper 1.6 mg 80% > Taurine 400 mg > EPA Omega-3 Fatty Acids 180 mg > DHA Omega-3 Fatty Acids 120 mg > Lutein (free, not esterified) 8 mg > Zeaxanthin 400 mcg > > BMC Ophthalmol. 2007; 7: 3. > Published online 2007 February 26. doi: 10.1186/1471-2415-7-3.> Copyright © 2007 Cangemi; licensee BioMed Central Ltd.> > > A 87yo friend says her eyes are no better after a year, but they're not getting any worse.> > Regards> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 9, 2008 Report Share Posted August 9, 2008 Hi JW: Also this from PMID: 9177242 ................ http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=21074 & blobname=pq1271116001.jpg Note especially that in this study, shown in the right hand diagram, there seems to be a threshold, around an intake of 0.5 AGE Ux10^6/kg, below which ingested AGEs are handled successfully by the body. But beyond the threshold amount the level in serum increases rapidly. Rodney. > >> > My focus is brainal diseases so I looked at AGEs and ARMD, probably my> worst concern.> > Cause of ARMD is unknown but they're looking at possible indicators:> > In AMD, activation of the RAGE axis in RPE cells may contribute to> upregulation of VEGF, potentially inciting or propagating neovascular> macular disease.PMID: 17325184> >> >> >> > The choroid is the element back of the retina that fills with stuff,> blocking circulation.> >> > The CML adduct releases TNF alpha which might induce the production> and release of VEGF for the abnormal choroidal neovascularization in the> patients of age-related macular degeneration. PMID: 17202673> >> >> > This author makes quite positive statements:> > Advanced glycation endproduct (AGE) formation is a trigger for the> onset of age-related disease. ...> > A subset of transcriptional changes is similar to early> atherosclerosis, a chronic inflammatory disease characterized by matrix> expansion and lipid deposition. These changes suggest an important> contribution of a single environmental stimulus to the complex aging> response. PMID: 16081535> >> >> > And it's dose dependent:> > AGE accumulation, as occurs with normal aging and in disease, may> induce receptor-mediated activation of RPE/photoreceptor cells,> contributing to disease progression in the aging human retinas. PMID:> 15452081> >> > And:> > CONCLUSIONS: These results indicate that glycoxidation products are> present in subretinal membranes of patients with ARMD. The concomitant> expression of RAGE in these membranes and the finding of activated NFkB> is suggestive of an implication of glycoxidation product formation in> the pathogenesis of the disease. PMID: 10393061> >> > So the choroid fills with stuff and starts the first phase which is> called "dry" since it's not "bleeding" thru. At some point, the bleeding> (wet type) starts and they try to stop it with laser therapy.> > ARMD radically changes a person's life.> >> > The AREDS study put forth a supplement called TOZAL> > TOZAL = taurine, omega-3 fatty acids {fish oil}, zinc, antioxidants> and lutein.> >> http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed & pubmedid\> =17324285> >> > Table 2> > Nutritional supplement formulation> >> > Component Weight Percent of daily value> > Vitamin A (total) 28,640 IU 573%> > Vitamin A 10,000 IU> > Natural Beta-Carotene 18,640 IU> > Vitamin C 452 mg 753%> > Vitamin E 200 IU 667%> > Zinc Oxide 69.6 mg 464%> > Copper 1.6 mg 80%> > Taurine 400 mg> > EPA Omega-3 Fatty Acids 180 mg> > DHA Omega-3 Fatty Acids 120 mg> > Lutein (free, not esterified) 8 mg> > Zeaxanthin 400 mcg> >> > BMC Ophthalmol. 2007; 7: 3.> > Published online 2007 February 26. doi: 10.1186/1471-2415-7-3.> > Copyright © 2007 Cangemi; licensee BioMed Central Ltd.> >> >> > A 87yo friend says her eyes are no better after a year, but they're> not getting any worse.> >> > Regards> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted August 10, 2008 Report Share Posted August 10, 2008 Am I correct in thinking that if we eat no browned foods, or preserved meats, we might never get to 0.5 AU *10^6 = 500,000 AU per KG body weight? Coffee/tea OTO of 2000. Even diet coke 10,000? PMID: 18448830 says they compared 15 AU vs 2750 AU meals, and the effects were dramatic, and improved by changing the cooking method. {so the 500,000 is suspect) No doubt browned food is something I can easily avoid. Notice: "Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. PMID: 16936154 Benfotiamine is a fat soluble thiamine Quote Link to comment Share on other sites More sharing options...
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