Tomatoes ==> prostate cancer?

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Does tomato consumption increase prostate cancer's risk? The below papers are free full-text.Darlington GA, Kreiger N, Lightfoot N, Purdham J, Sass-Kortsak A.Prostate cancer risk and diet, recreational physical activity and cigarette smoking.Chronic Dis Can. 2007;27(4):145-53.PMID: 17623560http://www.phac-aspc.gc.ca/publicat/cdic-mcc/27-4/pdf/cdic274-2_e.pdfAssociations between prostate cancer and dietary factors, physical activity and smoking were assessed based on data from a population-based case-control study. The study was conducted among residents of northeastern Ontario. Cases were identified from the Ontario Cancer Registry and diagnosed between 1995 and 1998 at ages 50 to 84 years (N=752). Male controls were

identified from telephone listings and were frequency matched to cases on age (N=1,613). Logistic regression analyses investigated history of diet, physical activity and smoking as potential risk factors. Tomato intake had a significant positive association with prostate cancer risk for highest versus lowest quartiles (OR=1.6; 95 percent CI: 1.2-2.0). Associations were observed for tomato or vegetable juices and ketchup (OR=1.5; 95 percent CI: 1.2-1.9; OR=1.2; 95 percent CI: 1.0-1.5, respectively). Neither other dietary variables nor smoking were associated with prostate cancer risk. Strenuous physical activity by men in their early 50s was associated with reduced risk (OR=0.8; 95 percent CI: 0.6-0.9). While the recreational physical activity association was consistent with results from previous studies, the tomato products association was not.Cohen JH, Kristal AR, Stanford JL.Fruit and vegetable intakes and prostate cancer risk.J

Natl Cancer Inst. 2000 Jan 5;92(1):61-8.PMID: 10620635http://jnci.oxfordjournals.org/cgi/content/full/92/1/61http://jnci.oxfordjournals.org/cgi/reprint/92/1/61-- Al Pater, alpater@...

[Guest guest]

I was questioned off-list about whether I really believed the story based on the below. Prospective studies seemed better and the below paper is free full-text.

Gann PH, Ma J, Giovannucci E, Willett W, Sacks FM, Hennekens CH, Stampfer MJ.Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis.Cancer Res. 1999 Mar 15;59(6):1225-30.PMID: 10096552

http://cancerres.aacrjournals.org/cgi/content/full/59/6/1225

http://cancerres.aacrjournals.org/cgi/reprint/59/6/1225-- Aalt Pater

From: Al Pater <old542000@...>Subject: Tomatoes ==> prostate cancer? Date: Sunday, September 14, 2008, 10:58 AM

Does tomato consumption increase prostate cancer's risk? The below papers are free full-text.Darlington GA, Kreiger N, Lightfoot N, Purdham J, Sass-Kortsak A.Prostate cancer risk and diet, recreational physical activity and cigarette smoking.Chronic Dis Can. 2007;27(4):145-53.PMID: 17623560http://www.phac-aspc.gc.ca/publicat/cdic-mcc/27-4/pdf/cdic274-2_e.pdfAssociations between prostate cancer and dietary factors, physical activity and smoking were assessed based on data from a population-based case-control study. The study was conducted among residents of northeastern Ontario. Cases were identified from the Ontario Cancer Registry and diagnosed between 1995 and 1998 at ages 50 to 84 years (N=752). Male controls were identified from telephone listings and were frequency matched

to cases on age (N=1,613). Logistic regression analyses investigated history of diet, physical activity and smoking as potential risk factors. Tomato intake had a significant positive association with prostate cancer risk for highest versus lowest quartiles (OR=1.6; 95 percent CI: 1.2-2.0). Associations were observed for tomato or vegetable juices and ketchup (OR=1.5; 95 percent CI: 1.2-1.9; OR=1.2; 95 percent CI: 1.0-1.5, respectively). Neither other dietary variables nor smoking were associated with prostate cancer risk. Strenuous physical activity by men in their early 50s was associated with reduced risk (OR=0.8; 95 percent CI: 0.6-0.9). While the recreational physical activity association was consistent with results from previous studies, the tomato products association was not.Cohen JH, Kristal AR, Stanford JL.Fruit and vegetable intakes and prostate cancer risk.J Natl Cancer Inst. 2000 Jan 5;92(1):61-8.PMID: 10620635http://jnci.oxfordjournals.org/cgi/content/full/92/1/61http://jnci.oxfordjournals.org/cgi/reprint/92/1/61-- Al Pater, alpater@...