Genetic variation in the murine lifespan response to dietary restriction.

[Guest guest]

Hello,

Sorry

for my unperfected English : I am French.

I

think that nobody in this Group has spoken about the study below,

apparently published in last October and presented at the 2009 CR Society

conference.

Do

you think it is reliable?

Benoit

(Benedict in English)

Genetic variation in the murine lifespan response to dietary

restriction: from life extension to life shortening

Chen-Yu Liao 1,2 , Brad A. Rikke 3,* ,

E. 3,4,* , Vivian 2 and F. 1,2,*

1 Department of Physiology, University of Texas Health Science

Center at San , San , TX 78229, USA

2 Barshop

Institute for Longevity and Aging Studies, University of Texas Health Science

Center at San , San , TX 78229, USA

3 Institute

for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA

4 Department

of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA

Correspondence to F. , Department of Physiology

and Barshop Institute for Longevity and Aging Studies, 15355 Lambda Drive,

University of Texas Health Science Center at San , TX 78245, USA. Tel.:

+1 210 562 6132;

fax: +1 210 562 6130; e-mail: nelsonj@...

*These authors contributed

equally to this study.

Copyright Journal compilation © 2010 Blackwell

Publishing Ltd/The Anatomical Society of Great Britain and Ireland

KEYWORDS

calorie restriction • food restriction • lifespan • longevity •

nutrition

ABSTRACT

Chronic

dietary restriction (DR) is considered among the most robust life-extending

interventions, but several reports indicate that DR does not always extend and

may even shorten lifespan in some genotypes. An unbiased genetic screen of the

lifespan response to DR has been lacking. Here, we measured the effect of one

commonly used level of DR (40% reduction in food intake) on mean lifespan of

virgin males and females in 41 recombinant inbred strains of mice. Mean

strain-specific lifespan varied two to threefold under ad libitum (AL)

feeding and 6- to 10-fold under DR, in males and females respectively. Notably,

DR shortened lifespan in more strains than those in which it lengthened life.

Food intake and female fertility varied markedly among strains under AL

feeding, but neither predicted DR survival: therefore, strains in which DR

shortened lifespan did not have low food intake or poor reproductive potential.

Finally, strain-specific lifespans under DR and AL feeding were not correlated,

indicating that the genetic determinants of lifespan under these two conditions

differ. These results demonstrate that the lifespan response to a single level

of DR exhibits wide variation amenable to genetic analysis. They also show that

DR can shorten lifespan in inbred mice. Although strains with shortened

lifespan under 40% DR may not respond negatively under less stringent DR, the

results raise the possibility that life extension by DR may not be universal.

Accepted

for publication 16 October 2009

http://www3.interscience.wiley.com/journal/122670409/abstract