Re:Bad eating may permanently alter DNA

[Guest guest]

Being a sugaholic, I permit myself a major sugar hit every

two weeks or so. I’ve felt relatively comfortable, with this, since my

average caloric count over the month, and other parameters like blood lipid

values etc, come out OK for me.

Reading Diane´s post below, makes me pause – should I

discontinue this heavenly source of sugar-loaded feast once in a while? When I

searched the Journal of Experimental Medicine, I couldn´t find the actual

article, perhaps Diane could help direct me.

Ulf

Posted by:

" Diane Walter " dianepwalter@...

dianepwalter

Tue Jan 20, 2009

12:08 pm (PST)

The

following corroborates the work described in CRSupportgroup

message 26387 that pointed to a generational effect with caloric

restriction.

New study:

Human genes remember a sugar hit for two weeks, with prolonged poor

eating habits capable of permanently altering DNA, Australian research

has found.

A team studying the impact of diet on human heart tissue and mice

found that cells showed the effects of a one-off sugar hit for a

fortnight, by switching off genetic controls designed to protect the

body against diabetes and heart disease.

" We now know that chocolate bar you had this morning can have very

acute effects, and those effects can continue for up to two weeks, "

said lead researcher Sam El-Osta, from the Baker IDI Heart and

Diabetes Institute.

" These changes continue beyond the meal itself and have the ability to

alter natural metabolic responses to diet, " he told Australian

Associated Press Friday.

Regular poor eating would amplify the effect, said El-Osta, with

genetic damage lasting months or years, and potentially passing

through bloodlines.

The study's findings were reported in the Journal of Experimental

Medicine.

Old study:

( /message/26387)

[Guest guest]

I don’t think this question can be answered. But.......

I wonder how many of us “stray”? I would guess a large number.

One suggestion: drink a glass of red wine with your sugar fix. It supposedly ameliorates bad food if you remember the study posted on this topic – at least in mice IIRC. And the study below was in mice as well, so who knows if it is applicable to people?

My own theory is that red wine is a large factor in the benefits of the Mediterranean diet. You might investigate how much sugar is included in the typical med diet to allay (or not allay) your sugar fears.

Can you satisfy the sweet tooth with fruit and /or more benign sweets like allfruit jam for example?

From: Ulf Rasmusson <ulf.rasmusson@...>

Reply-< >

Date: Sun, 22 Feb 2009 11:26:05 +0100

< >

Subject: [ ] Re:Bad eating may permanently alter DNA

Being a sugaholic, I permit myself a major sugar hit every two weeks or so. I’ve felt relatively comfortable, with this, since my average caloric count over the month, and other parameters like blood lipid values etc, come out OK for me.

Reading Diane´s post below, makes me pause – should I discontinue this heavenly source of sugar-loaded feast once in a while? When I searched the Journal of Experimental Medicine, I couldn´t find the actual article, perhaps Diane could help direct me.

Ulf

Posted by: " Diane Walter " dianepwalter@... <mailto:dianepwalter@...?Subject=%20Re%3ABad%20eating%20may%20permanently%20alter%20DNA> dianepwalter <dianepwalter>

Tue Jan 20, 2009 12:08 pm (PST)

The following corroborates the work described in CRSupportgroup

message 26387 that pointed to a generational effect with caloric

restriction.

New study:

Human genes remember a sugar hit for two weeks, with prolonged poor

eating habits capable of permanently altering DNA, Australian research

has found.

A team studying the impact of diet on human heart tissue and mice

found that cells showed the effects of a one-off sugar hit for a

fortnight, by switching off genetic controls designed to protect the

body against diabetes and heart disease.

" We now know that chocolate bar you had this morning can have very

acute effects, and those effects can continue for up to two weeks, "

said lead researcher Sam El-Osta, from the Baker IDI Heart and

Diabetes Institute.

" These changes continue beyond the meal itself and have the ability to

alter natural metabolic responses to diet, " he told Australian

Associated Press Friday.

Regular poor eating would amplify the effect, said El-Osta, with

genetic damage lasting months or years, and potentially passing

through bloodlines.

The study's findings were reported in the Journal of Experimental

Medicine.

Old study:

( /message/26387 < /message/26387> )

[Guest guest]

Hi All,

pdfs are availed of papers.

http://www.newsmax.com/health/eating_habits_alter_DNA/2009/01/19/172911.html

Assam El-Osta, la Brasacchio, Dachun Yao, Alessandro Pocai, L. , G. Roeder, Mark E. , and BrownleeTransient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemiaJ. Exp. Med., Sep 2008; 205: 2409 - 2417.

The current goal of diabetes therapy is to reduce time-averaged mean levels of glycemia, measured as HbA1c, to prevent diabetic complications. However, HbA1c only explains <25% of the variation in risk of developing complications. Because HbA1c does not correlate with glycemic variability when adjusted for mean blood glucose, we hypothesized that transient spikes of hyperglycemia may be an HbA1c–independent risk factor for diabetic complications. We show that transient hyperglycemia induces long-lasting activating epigenetic changes in the promoter of the nuclear factor kappa-B (NF-kappa- subunit p65 in aortic endothelial cells both in vitro and in nondiabetic mice, which cause increased p65 gene expression. Both the epigenetic changes and the gene expression changes persist for at least 6 d of subsequent normal glycemia, as do NF-kappa-B–induced increases in monocyte chemoattractant protein 1 and vascular cell adhesion molecule 1

expression. Hyperglycemia-induced epigenetic changes and increased p65 expression are prevented by reducing mitochondrial superoxide production or superoxide-induced alpha-oxoaldehydes. These results highlight the dramatic and long-lasting effects that short-term hyperglycemic spikes can have on vascular cells and suggest that transient spikes of hyperglycemia may be an HbA1c–independent risk factor for diabetic complications.

Abbreviations used: BAEC, bovine aortic endothelial cell; ChIP, chromatin immunoprecipitation; cChIP, carrier ChIP; CVD, cardiovascular disease; GLO1, glyoxalase 1; H3k4me1, histone 3 lysine 4 monomethylation; H3K4me2, H3K4 dimethylation; H3K4me3, H3K4 trimethylation 4; HAEC, human aortic endothelial cell; HG, high glucose; HMT, histone methyltransferases; LCM, laser capture microdissection; LG, low glucose; MCP-1 monocyte chemoattractant protein 1; MnSOD, manganese superoxide dismutase; ROS, reactive oxygen species; TSA, trichostatin A; TSS, transcription start site; UCP-1, uncoupling protein 1; VCAM-1, vascular cell adhesion molecule 1.

Related In this Issue article

The lowdown on sugar highs Hema BashyamJ. Exp. Med. 2008 205: 2183.-- Aalt Pater

From: Ulf Rasmusson <ulf.rasmusson@...>Subject: [ ] Re:Bad eating may permanently alter DNA Date: Sunday, February 22, 2009, 2:26 AM

Being a sugaholic, I permit myself a major sugar hit every two weeks or so. I’ve felt relatively comfortable, with this, since my average caloric count over the month, and other parameters like blood lipid values etc, come out OK for me.

Reading Diane´s post below, makes me pause – should I discontinue this heavenly source of sugar-loaded feast once in a while? When I searched the Journal of Experimental Medicine, I couldn´t find the actual article, perhaps Diane could help direct me.

Ulf

Posted by: "Diane Walter" dianepwalter dianepwalter

Tue Jan 20, 2009 12:08 pm (PST)

The following corroborates the work described in CRSupportgroupmessage 26387 that pointed to a generational effect with caloricrestriction. New study:Human genes remember a sugar hit for two weeks, with prolonged pooreating habits capable of permanently altering DNA, Australian researchhas found.A team studying the impact of diet on human heart tissue and micefound that cells showed the effects of a one-off sugar hit for afortnight, by switching off genetic controls designed to protect thebody against diabetes and heart disease."We now know that chocolate bar you had this morning can have veryacute effects, and those effects can continue for up to two weeks,"said lead researcher Sam El-Osta, from the Baker IDI Heart andDiabetes Institute."These changes continue beyond the meal itself

and have the ability toalter natural metabolic responses to diet," he told AustralianAssociated Press Friday.Regular poor eating would amplify the effect, said El-Osta, withgenetic damage lasting months or years, and potentially passingthrough bloodlines.The study's findings were reported in the Journal of ExperimentalMedicine.Old study:(http://health. groups.. com/group/ / message/26387)

[Guest guest]

Hi Ulf:

I also find this result interesting. When they say the effects can

last for two weeks what is the effect they are talking about? I.E.

what is the evidence they are looking at to say the effect lasts two

weeks?

I ask because over the past couple of years I have had two apparently

aberrant fasting glucose tests - one 6.3 and the other 6.0. Each

time the HbA1c result was between 5 and 6 and the follow up glucose

tests were between 4 and 5.

Diane's post makes me wonder whether one of the numbers they are

talking about - which is affected for as much as two weeks - may be

fasting glucose. In other words a sixteen hour fast may not be

anywhere near long enough to wash out an aberrant occasional 'sugar-

hit'. And I am wondering if this may be the explanation for my

apparently abberant results noted above. And whether my occasional

consumption of chocolate chips should be more restrained, or indulged

in less often!

It would be helpful to know, I think, if fasting glucose is among the

long-lasting effects to which they refer.

Rodney.

>

> Being a sugaholic, I permit myself a major sugar hit every two

weeks or so.

> I've felt relatively comfortable, with this, since my average

caloric count

> over the month, and other parameters like blood lipid values etc,

come out

> OK for me.

>

> Reading Diane´s post below, makes me pause – should I discontinue

this

> heavenly source of sugar-loaded feast once in a while? When I

searched the

> Journal of Experimental Medicine, I couldn´t find the actual

article,

> perhaps Diane could help direct me.

>

> Ulf

>

>

>

> Posted by: " Diane Walter "

> <mailto:dianepwalter@...?Subject=%20Re%3ABad%20eating%20may%

20permanen

> tly%20alter%20DNA> dianepwalter@...

> <dianepwalter> dianepwalter

>

> Tue Jan 20, 2009 12:08 pm (PST)

>

> The following corroborates the work described in CRSupportgroup

> message 26387 that pointed to a generational effect with caloric

> restriction.

>

> New study:

> Human genes remember a sugar hit for two weeks, with prolonged poor

> eating habits capable of permanently altering DNA, Australian

research

> has found.

>

> A team studying the impact of diet on human heart tissue and mice

> found that cells showed the effects of a one-off sugar hit for a

> fortnight, by switching off genetic controls designed to protect the

> body against diabetes and heart disease.

>

> " We now know that chocolate bar you had this morning can have very

> acute effects, and those effects can continue for up to two weeks, "

> said lead researcher Sam El-Osta, from the Baker IDI Heart and

> Diabetes Institute.

>

> " These changes continue beyond the meal itself and have the ability

to

> alter natural metabolic responses to diet, " he told Australian

> Associated Press Friday.

>

> Regular poor eating would amplify the effect, said El-Osta, with

> genetic damage lasting months or years, and potentially passing

> through bloodlines.

>

> The study's findings were reported in the Journal of Experimental

> Medicine.

>

> Old study:

> (

< /message/26387>

> /message/26387)

>