Mice supplemented with 30 substances, some of them weird (?)

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Also forgot to add that I also take a baby aspirin (don’t know if this even qualifies as a supplement) and melatonin. Fish oil, D3, aspirin and melatonin have all been cited as beneficial to health in studies posted here and those studies can be archived or found in our files.

On 3/22/10 8:12 PM, " Francesca Skelton " <fskelton@...> wrote:

FWIW, I now only take fish oil and D. I’ve expounded on my reasons in previous posts which can be archived by anyone interested;, I will just repeat that the fish oil adds a visible improvement to my hair and appearance which assures me that it is doing something good.

Of course if something else proves beneficial, I’ll add it to my regimen. At one point I did take acetyl-L-carnitine and alpha lipoic acid but I stopped after not noticing an enhanced sense of well being or anything else I could point to. I also took resveratrol and then stopped (but I do drink red wine).

The supplement “du jour” I suspect, whatever it is, at the height of its’ popularity, enriches its’ makers while not necessarily enhancing the health of its’ users and perhaps may be harmful. I can think of a few which did prove harmful in the long run.

I suspect that you didn’t get much of a response (with the exception of one post from ) because, well..... who knows?

I do recall some research on Gingko which debunked it as being of any value.

On 3/22/10 7:48 PM, " perspect1111 " <perspect1111@...> wrote:

Hi folks:

With the below-attached post of mine I was hoping to elicit thoughts from the group as to whether some of these thirty listed supplements might be worth taking. Of course we do not know whether the research will be replicated. Nor do we know which, if any, of the substances were responsible for the remarkable claimed effects.

Of the 30, I am already 'taking' about 17 of them - all the vitamins listed for example. But what about the 13 others? Cod liver oil will be eliminated quickly from some people's lists for its retinol content. The listed 'bioflavonoids' and rutin (another bioflavonoid, I believe), seem harmless enough. And supplementing some ginger occasionally wouldn't be especially remarkable.

But how about the ones with complicated-sounding chemical names, like acetyl-L-carnitine, alpha lipoic acid, L-glutathione, or N-acetyl cysteine?

Or how about ginseng or ginkgo?

Probably the right answer to all this is that it is much too early to draw any conclusions worth acting on, on the basis of this one study.

But if anyone has any serious thoughts about evidence of potential benefit from any of these substances, I would be intersted to hear them. My impression is that for most of them the evidence is sparse, or not very well researched.

Rodney.

> >

> > I would say, yes: " complex dietary cocktails can powerfully ameliorate biomarkers of aging and modulate mechanisms considered ultimate goals for aging interventions. "

> > The below paper is free-text including pdf-availed.

> >

> > NEUROSCIENCE:

> > Vadim Aksenov, Jiangang Long, Sonali Lokuge, Jane A , Jiankang Liu, and C Rollo

> > Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging

> > Exp Biol Med, January 2010; 235: 66 - 76.

> > http://ebm.rsmjournals.com/cgi/reprint/235/1/66?maxtoshow= & hits=10 & RESULTFORMAT=1 & author1=rollo & andorexacttitle=and & andorexacttitleabs=and & andorexactfulltext=and & searchid=1 & FIRSTINDEX=0 & sortspec=relevance & resourcetype=HWCIT <http://ebm.rsmjournals.com/cgi/reprint/235/1/66?maxtoshow= & amp;hits=10 & amp;RESULTFORMAT=1 & amp;author1=rollo & amp;andorexacttitle=and & amp;andorexacttitleabs=and & amp;andorexactfulltext=and & amp;searchid=1 & amp;FIRSTINDEX=0 & amp;sortspec=relevance & amp;resourcety>

> > http://tinyurl.com/yhng569

> >

> > Abstract

> >

> > Aging degrades motivation, cognition, sensory modalities and physical

> > capacities, essentially dimming zestful living. Bradykinesis (declining

> > physical movement) is a highly reliable biomarker of aging and mortality

> > risk.

> >

> > Mice fed a complex dietary supplement (DSP) designed to ameliorate five

> > mechanisms associated with aging showed no loss of total daily locomotion

> > compared with >50% decrement in old untreated mice. This was associated with

> > boosted striatal neuropeptide Y, reversal of age-related declines in

> > mitochondrial complex III activity in brain and amelioration of oxidative

> > stress (brain protein carbonyls). Supplemented mice expressed 50% fewer

> > mitochondrial protein carbonyls per unit of complex III activity. Reduction

> > of free radical production by mitochondria may explain the exceptional

> > longevity of birds and dietary restricted animals and no DSP is known to

> > impact this mechanism. Functional benefits greatly exceeded the modest

> > longevity increases documented for supplemented normal mice.

> >

> > Regardless, for aging humans maintaining zestful health and performance into

> > later years may provide greater social and economic benefits than simply

> > prolonging lifespan. Although identifying the role of specific ingredients

> > and interactions remains outstanding, results provide proof of principle

> > that complex dietary cocktails can powerfully ameliorate biomarkers of aging

> > and modulate mechanisms considered ultimate goals for aging interventions.

> >

> > Keywords: aging, locomotion, mitochondria, protein carbonyls, neuropeptide

> > Y, free radicals, energy regulation, growth hormone, mice, dietary

> > supplement

> >

> > ...

> >

> > Table 1 Ingredients included in the complex dietary supplement.

> > ------------------------------------------------

> > Ingredient Mouse dose (mg/day/100 mice)

> > ------------------------------------------------

> > Vitamin B1 30.49

> > Ginko biloba 18.29

> > Vitamin B3 (niacin) 30.49

> > Ginseng 631.1

> > Vitamin B6 60.98

> > Green tea extract 487.8

> > Vitamin B12 0.18

> > L-Glutathione 30.49

> > Vitamin C 350.61

> > Magnesium 45.73

> > Vitamin D 0.02

> > Manganese 19.05

> > Acetyl L-carnitine 146.45

> > Melatonin 0.73

> > Alpha-lipoic acid 182.93

> > N-acetyl cysteine 304.88

> > Acetylsalicylic acid 132.11

> > Potassium 18.11

> > Beta carotene 21.95

> > Rutin 304.88

> > Bioflavonoids 792.68

> > Selenium 0.05

> > Chromium picolinate 0.30

> > Vitamin E 326.83

> > Folic acid 0.61

> > Cod liver oil (Omega 3) 1219.51

> > Garlic 3.81

> > Coenzyme Q10 60.98

> > Ginger root extract 600.37

> > Flax seed oil 1219.51

> > ------------------------------------------------

> >

> > -- Aalt Pater

> >

> >

> > __________________________________________________________

> > Canada Toolbar: Search from anywhere on the web, and bookmark your favourite sites. Download it now

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> >

>

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