Guest guest Posted December 11, 2008 Report Share Posted December 11, 2008 If you mean Rod’s posts about the high levels of Vit D he’s been taking, I think you are mistaken that he has “recommended” those levels. He was experimenting and telling us about it but not actually recommending that others follow his protocol. I take only 1,000 IU. I don’t take any during the summer months. From: andiemock <andiemock@...> Reply-< > Date: Thu, 11 Dec 2008 01:56:23 -0000 < > Subject: [ ] Vit D level too good Hi - I was following a protocol rec'd here: 50,000 IU of Vit D3, every three days though I took it just a few times a month. It seems that it's worked too good. My Vitamin D level is 121. Normal range is 40. Has anyone else had this problem? I am thinking of taking this dose once every two months. The half-life for Vit D is about 8 weeks. Any further recommendations? My T4 is slightly elevated - 12.8 (high end is 12) Also, my total cholesterol is 270 with HDL at 101 LDL 169. Most places I read that I'm okay with such a high HDL. My doctor is not so sure about this decreased risk due to high HDL. Is this pretty respectable science? Lipo A is in desirable range. I don't eat any dairy (lactose intolerant) and very little meat. No amount of dietary changes have ever affected my LDL. It's stayed steady for 30 years. Triglycerides are in a good range. Thanks, Andie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 11, 2008 Report Share Posted December 11, 2008 Vit D is fat soluble so we store it, and there is such a thing as too much. You apparently don't need to supplement that much if at all. What was your Vit D level before supplementing ?Public health services have been pretty good about managing large scale deficiencies in our population, we probably only need to worry if on some stupid diet.Eating a balanced selection of whole foods should keep us healthy enough to die from something else...JROn Dec 10, 2008, at 7:56 PM, andiemock wrote:Hi - I was following a protocol rec'd here:50,000 IU of Vit D3, every three days though I took it just a fewtimes a month. It seems that it's worked too good. My Vitamin D level is 121. Normalrange is 40.Has anyone else had this problem? I am thinking of taking this doseonce every two months. The half-life for Vit D is about 8 weeks.Any further recommendations?My T4 is slightly elevated - 12.8 (high end is 12)Also, my total cholesterol is 270 with HDL at 101 LDL 169. Most placesI read that I'm okay with such a high HDL. My doctor is not so sureabout this decreased risk due to high HDL. Is this pretty respectablescience? Lipo A is in desirable range.I don't eat any dairy (lactose intolerant) and very little meat. Noamount of dietary changes have ever affected my LDL. It's stayedsteady for 30 years.Triglycerides are in a good range. Thanks,Andie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 11, 2008 Report Share Posted December 11, 2008 50,000 IU once a week for 8 weeks is one of the recommended protocols to treat a deficiency but not as an ongoing supplement. Current daily recommendations out there range from around 800, 1000, to 2000 IU/day/ Regards Jeff Francesca Skelton wrote: > > If you mean Rod’s posts about the high levels of Vit D he’s been > taking, I think you are mistaken that he has “recommended” those > levels. He was experimenting and telling us about it but not actually > recommending that others follow his protocol. > > I take only 1,000 IU. I don’t take any during the summer months. > > ------------------------------------------------------------------------ > *From: *andiemock <andiemock@...> > *Reply-*< > > *Date: *Thu, 11 Dec 2008 01:56:23 -0000 > **< > > *Subject: *[ ] Vit D level too good > > > > > Hi - > > I was following a protocol rec'd here: > > 50,000 IU of Vit D3, every three days though I took it just a few > times a month. > > It seems that it's worked too good. My Vitamin D level is 121. Normal > range is 40. > > Has anyone else had this problem? I am thinking of taking this dose > once every two months. The half-life for Vit D is about 8 weeks. > > Any further recommendations? > > My T4 is slightly elevated - 12.8 (high end is 12) > > Also, my total cholesterol is 270 with HDL at 101 LDL 169. Most places > I read that I'm okay with such a high HDL. My doctor is not so sure > about this decreased risk due to high HDL. Is this pretty respectable > science? Lipo A is in desirable range. > > I don't eat any dairy (lactose intolerant) and very little meat. No > amount of dietary changes have ever affected my LDL. It's stayed > steady for 30 years. > Triglycerides are in a good range. > > Thanks, > > Andie > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 11, 2008 Report Share Posted December 11, 2008 Hello Andi, Several issues here: You said that your Vitamin D level is 121. There are two tests for Vitamin D. Did you get the correct test? The correct test is 25- hydroxy-Vitamin D. Sometimes you will see this as 25(OH)D. Also, what are the units? In the United States, typically the units are in ng/ml (nanograms per milliliter). The reference range for most labs in the U.S. is 32-100 ng/ml, but most Vitamin D experts believe that this low end is too low, and the high end is too high. The Vitamin D experts generally believe that the range should be roughly 40-60 ng/ml. A 25-hydroxy-Vitamin D level of 121 ng/ml (if that's the test you had and the correct units) is too high. (That's not a storage level in the body, it's a circulating blood level of a precursor to the active form of Vitamin D) Vitamin D very substantially increases the amount of calcium that we absorb from our gut, and the risk of " hypervitaminosis D " is the risk of calcifying tissues……Vitamin D toxicity is not something to mess with. You should also have your blood calcium level checked. If I were you, I would stop taking any sources of Vitamin D immediately (regardless of blood calcium level), and also limit my calcium intake until my Vitamin D blood test was back down to normal. You might want a physician to monitor and supervise this whole process, probably an endocrinologist. You can't follow any " protocol " , such as 50,000 IU Vit D every such and such an interval, without frequent 25-hydroxy-Vitamin D testing. You don't know how efficient your skin is in making Vitamin D precursors. This has to do with the pigmentation of your skin, where you live, the amount of sun exposure you get, how much of your skin gets sun exposure, the time of day you get sun exposure, and individual differences. You said that your T4 is slightly elevated. Is that free T4 that was measured? What were your Free T3 and TSH like? Total cholesterol 270 and LDL of 169, HDL 101. Wow……this is a tricky issue, because it cannot be said with certainty that the high HDL will protect you from the high LDL and high total cholesterol. (But it very well may). BTW, what were your triglycerides and VLDL?. There are different sub-fractions of HDL. Some are very heart protective, and some are not very heart protective. The large, fluffy particles are the most protective…..but almost nobody knows what types/subfractions of HDL predominate in their blood, as these are not the standard lab tests. It's much safer to try and lower the LDL and the Total Cholesterol. LDL should be less than 100 mg/dl……Total cholesterol less than 200 mg/dl. Go through your family history: any family history of coronary artery disease, myocardial infarct (heart attack), stroke, peripheral vascular disease? Have you seen a cardiologist about your lipid profile? You should get a hs-CRP test (high sensitivity C-reactive protein blood test). This is a test for inflammation, and high levels are correlated with coronary artery disease, which has a significant inflammatory component to it. Is your body weight ideal or close to it? You said that no dietary changes have ever affected your LDL. But what dietary changes have you tried? Dietary changes to try and affect a lipid profile like yours would have to be dramatic…..that's all for now Bob B. --- In , " andiemock " <andiemock@...> wrote: > > Hi - > > I was following a protocol rec'd here: > > 50,000 IU of Vit D3, every three days though I took it just a few > times a month. > > It seems that it's worked too good. My Vitamin D level is 121. Normal > range is 40. > > Has anyone else had this problem? I am thinking of taking this dose > once every two months. The half-life for Vit D is about 8 weeks. > > Any further recommendations? > > My T4 is slightly elevated - 12.8 (high end is 12) > > Also, my total cholesterol is 270 with HDL at 101 LDL 169. Most places > I read that I'm okay with such a high HDL. My doctor is not so sure > about this decreased risk due to high HDL. Is this pretty respectable > science? Lipo A is in desirable range. > > I don't eat any dairy (lactose intolerant) and very little meat. No > amount of dietary changes have ever affected my LDL. It's stayed > steady for 30 years. > Triglycerides are in a good range. > > Thanks, > > Andie > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 12, 2008 Report Share Posted December 12, 2008 Hi Andie: Sorry, but your post is so grossly in error in several respects that you may be in danger of doing a lot more harm than good to your health. Here are a few examples of what I mean: 1. When you use the term " rec'd " do you mean " recommended " ? If so then you clearly do not understand that no one here RECOMMENDS anything to anyone. The principal purpose of this site is to post scientific studies relating to health and longevity - especially CRON - and we EACH have to make up our own minds what we believe may be best for our health based on our understanding of that research. Occasionally people will share here what they are doing, and ask for input from others. The only thing that is recommended here is to read Walford, the contents of the files, and the science that gets posted here. Then YOU decide what you consider may be best for you. Very little in health and nutrition is settled science, except that CR greatly increases the average and maximum lifespans of all species tested to date. For just about all else the jury is still out and we each must place our bets as to what we think may be the best course based on our understanding of the science that is available. There are many different points of view here about most issues. 2. If it is your opinion that anyone here has ever recommended taking 50,000 units of vitamin D every two to three days kindly provide the number of the post in which you believe that recommendation was made. I have read every post here for about five years and I do not recall any such recommendation. 3. Saying that your " vitamin D level is 121 " is not very instructive. First what measure of vitamin D are you referring to? The only measure considered relevant by most sources is " serum 25(OH) D " . Is this what you are referring to? There are others. And if it is serum 25(OH)D, without knowing the units in which it was measured it means nothing. There are at least two sets of units commonly used to measure 25(OH)D. One is ng/milliliter. The other is nmol/liter. The number you quoted, 121, if measured in the first set of units would represent gross (dangerous) overdosing of vitamin D. But if by the second set of units then it would, as far as we know today, be a very healthy level. So, which is it? And if you do not know which it is you need to find out fast. 4. If your LDL is 169 and HDL is 101, then you total cholesterol is a lot more than 270. Almost certainly between 300 and 400. Total cholesterol is NOT the sum of LDL and HDL. And I do not think anyone here, or elsewhere, believes even a level of 270 is healthy, no matter how high your HDL. Take a look at the cholesterol levels normally attained by people established on CR (search the archives here for " WUSTL study " ) to find out the kinds of levels generally considered healthy. And with cholesterol levels that high I think it is unlikely you are pursuing a CRON diet. Just my take in response to what you posted. Rodney. --- In , " andiemock " <andiemock@...> wrote: > > Hi - > > I was following a protocol rec'd here: > > 50,000 IU of Vit D3, every three days though I took it just a few > times a month. > > It seems that it's worked too good. My Vitamin D level is 121. Normal > range is 40. > > Has anyone else had this problem? I am thinking of taking this dose > once every two months. The half-life for Vit D is about 8 weeks. > > Any further recommendations? > > My T4 is slightly elevated - 12.8 (high end is 12) > > Also, my total cholesterol is 270 with HDL at 101 LDL 169. Most places > I read that I'm okay with such a high HDL. My doctor is not so sure > about this decreased risk due to high HDL. Is this pretty respectable > science? Lipo A is in desirable range. > > I don't eat any dairy (lactose intolerant) and very little meat. No > amount of dietary changes have ever affected my LDL. It's stayed > steady for 30 years. > Triglycerides are in a good range. > > Thanks, > > Andie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2008 Report Share Posted December 13, 2008 > > > > Hi - > > > > I was following a protocol rec'd here: > > > > 50,000 IU of Vit D3, every three days though I took it just a few > > times a month. > > > > It seems that it's worked too good. My Vitamin D level is 121. > Normal > > range is 40. > > > > Has anyone else had this problem? I am thinking of taking this dose > > once every two months. The half-life for Vit D is about 8 weeks. > > > > Any further recommendations? > > > > My T4 is slightly elevated - 12.8 (high end is 12) > > > > Also, my total cholesterol is 270 with HDL at 101 LDL 169. Most > places > > I read that I'm okay with such a high HDL. My doctor is not so sure > > about this decreased risk due to high HDL. Is this pretty > respectable > > science? Lipo A is in desirable range. > > > > I don't eat any dairy (lactose intolerant) and very little meat. No > > amount of dietary changes have ever affected my LDL. It's stayed > > steady for 30 years. > > Triglycerides are in a good range. > > > > Thanks, > > > > Andie > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2008 Report Share Posted December 13, 2008 >>It's not fun being stupid in public but that's one way to learn and I have always learned a lot lurking on this list.<< IMHO, it is BEST to be 'stupid' in public, especially on a list where there are so many bright, caring people. That way, errors are caught & corrected, usually with gentleness & appropriate instruction. Just imagine what might have had happened if you had not made your statements publically, but instead had continued that level of Vit D.. Perish the thought!! Be blest! Marsha Quote Link to comment Share on other sites More sharing options...
Guest guest Posted December 13, 2008 Report Share Posted December 13, 2008 Hello Andie, Forget about the 'it's not fun looking stupid...' We all know just a little.....very little. The total cholesterol is the sum of the LDL plus the HDL plus the VLDL (very low density lipoprotein). https://www.labcorp.com/datasets/labcorp/html/chapter/mono/pr016500.ht m http://en.wikipedia.org/wiki/Cholesterol http://www.ehow.com/how_2088718_calculate-total-cholesterol.html Think of LDL as being the " bad cholesterol " . It has been public enemy number 1 in the war on cholesterol/war on coronary heart disease. Actually, LDL, VLDL and triglycerides are all " bad " , meaning that elevated levels are atherogenic, but LDL has been the most important target) A low HDL is also a cardiac risk factor, but this is definitely not your issue! VLDL is associated with triglycerides, and may be calculated by the formula: VLDL = triglycerides/5. Apparently this is not directly measured in a blood test...it is calculated. Total cholesterol and HDL are directly measured. LabCorb, one of the two largest Clinical Diagnostic Labs in the U.S., also calculates LDL, but apparently it CAN be directly measured; I haven't yet found out if Quest, the other of the two largest clinical labs in the U.S., still calculates LDL or now measures it directly... Think of HDL as " the good cholesterol " . It can carry cholesterol from the " periphery " (example, a coronary artery), back to the liver To complicate matters immensely, there are different " types " (sub- fractions) of HDL and LDL. Some persons have sub-fractions of HDL that are very heart protective; some have types of HDL that are not very protective. Likewise with LDL: some sub-types are more atherogenic than others. (and there is also an IDL---I for intermediate.....let's not even go there) But a standard lipid profile (which tells you total cholesterol, HDL, LDL, VLDL and triglycerides) does not tell you anything at all about the sub-fractions of your HDL and LDL----how cardioprotective your specific HDL is and how atherogenic your predominant type of LDL is. The next time I get bloodwork, I am going to try to order HDL and LDL sub-fractions....and see if the lab will do it Why are the stuff about " lipoproteins " ? (HDL, LDL, VLDL....the L stands for Lipoprotein? It's because cholesterol is not soluble in the blood, so it requires lipoproteins to carry them around in the blood.....think of them as carriers or tow-trucks. Regarding the Vitamin D, just a note that most primary care physicians have little knowledge about it.....so if that is the case with yours, an endocrinologist may be a better option. And you can call and " sceen " physicians before choosing them....by asking them (or their charge nurses) a few questions. And if you find out that you indeed have a 25-hydroxy-Vitamin D of 121 ng/ml (looking at the name of the test that was performed and the units), be aware that several foods have Vit D added to them ( " fortification " ).....and several supplements that you may not expect to have Vit D, have it....so carefully reading labels is very important to steal a line from Al, Cheers, Bob B. > > > > > > Hi - > > > > > > I was following a protocol rec'd here: > > > > > > 50,000 IU of Vit D3, every three days though I took it just a few > > > times a month. > > > > > > It seems that it's worked too good. My Vitamin D level is 121. > > Normal > > > range is 40. > > > > > > Has anyone else had this problem? I am thinking of taking this dose > > > once every two months. The half-life for Vit D is about 8 weeks. > > > > > > Any further recommendations? > > > > > > My T4 is slightly elevated - 12.8 (high end is 12) > > > > > > Also, my total cholesterol is 270 with HDL at 101 LDL 169. Most > > places > > > I read that I'm okay with such a high HDL. My doctor is not so sure > > > about this decreased risk due to high HDL. Is this pretty > > respectable > > > science? Lipo A is in desirable range. > > > > > > I don't eat any dairy (lactose intolerant) and very little meat. No > > > amount of dietary changes have ever affected my LDL. It's stayed > > > steady for 30 years. > > > Triglycerides are in a good range. > > > > > > Thanks, > > > > > > Andie > > > Quote Link to comment Share on other sites More sharing options...
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