Re: Anti-Aging Supplements May Be Best Taken Not Too Late in Life

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Anti-aging supplements may be best taken not too late in life

http://www.sciencedaily.com/releases/2010/05/100524114043.htm

Beneficial effects of a Q-ter based nutritional mixture on functional performance, mitochondrial function, and oxidative stress in rats.Xu J, Seo AY, Vorobyeva DA, CS, Anton SD, Lezza AM, Leeuwenburgh C.PLoS One. 2010 May 11;5(5):e10572.PMID: 20485503Free PMC ArticleFree texthttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868025/?tool=pubmedhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2868025/pdf/pone.0010572.pdf

Abstract

BACKGROUND: Mitochondrial dysfunction and oxidative stress are central mechanisms underlying the aging process and the pathogenesis of many age-related diseases. Selected antioxidants and specific combinations of nutritional compounds could target many biochemical pathways that affect both oxidative stress and mitochondrial function and, thereby, preserve or enhance physical performance. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we evaluated the potential anti-aging benefits of a Q-ter based nutritional mixture (commercially known as Eufortyn) mainly containing the following compounds: terclatrated coenzyme Q(10) (Q-ter), creatine and a standardized ginseng extract. We found that Eufortyn supplementation significantly ameliorated the age-associated decreases in grip strength and gastrocnemius subsarcolemmal mitochondria Ca(2+) retention capacity when initiated in male Fischer344 x Brown Norway rats at 21 months, but not 29 months, of age.

Moreover, the increases in muscle RNA oxidation and subsarcolemmal mitochondrial protein carbonyl levels, as well as the decline of total urine antioxidant power, which develop late in life, were mitigated by Eufortyn supplementation in rats at 29 months of age. CONCLUSIONS/SIGNIFICANCE: These data imply that Eufortyn is efficacious in reducing oxidative damage, improving the age-related mitochondrial functional decline, and preserving physical performance when initiated in animals at early midlife (21 months). The efficacy varied, however, according to the age at which the supplementation was provided, as initiation in late middle age (29 months) was incapable of restoring grip strength and mitochondrial function. Therefore, the Eufortyn supplementation may be particularly beneficial when initiated prior to major biological and functional declines that appear to occur with advancing age.

Footnotes

Competing Interests: The authors declare that they have no employment, consultancy, patents, products in development or marketed products with the company Pharmaland SA. The authors also declare that the following patent is not relevant to the article: Patent No: US 6,541,265 B2; Date of Patent Apr. 1, 2003. “Method and system to test a substance for inflammatory or oxidant propertiesâ€. Inventor: Christiaan Leeuwenburgh. Assignee: University of Florida, Gainesville, Florida (United States); Application No. 09/852,194; Filed May 9, 2001.

Funding: This work was supported by Pharmaland SA, grants to CL from the National Institute on Aging (AG17994), the University of Florida Institute on Aging and the Claude D. Pepper Older Americans Independence Center National Institutes of Health Grant (1 P30 AG028740), fellowship awards from the American Heart Association to JX (09POST2060112) and SDA (09CRP2390173 and 1K23AT004251), and a University Scholars Program award from the University of Florida Honors Program to DAV. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

There were surprises in the supplements that do or do not protect us from mortality, based on the pdf-availed below paper.

Vitamin D conversin is 1 IU = 0.025 microgram and so the high dose used at average 20 micrograms/day is 800. This seems to be pretty high for the nil benefit. Yet, glucosamine and chondroitin and maybe fish oil were significantly associated with longer living.

Even the Table 1 data seemed to inform vis a vis the relative risk of different factors, such as education, smoking, marital status, exercise., race and rating of our health..

Total mortality risk in relation to use of less-common dietary supplements.Pocobelli G, Kristal AR, RE, Potter JD, Lampe JW, Kolar A, I, White E.Am J Clin Nutr. 2010 Apr 21. [Epub ahead of print]PMID: 20410091

ABSTRACT

Background: Dietary supplement use is common in older US adults; however, data on health risks and benefits are lacking for a number of supplements.Objective: We evaluated whether 10-y average intakes of 13 vitamin and mineral supplements and glucosamine, chondroitin, saw palmetto, Ginko biloba, garlic, fish-oil, and fiber supplements were associated with total mortality.

Design: We conducted a prospective cohort study of Washington State residents aged 50-76 y during 2000-2002. Participants (n = 77,719) were followed for mortality for an average of 5 y.

Results: A total of 3577 deaths occurred during 387,801 person-years of follow-up. None of the vitamin or mineral 10-y average intakes were associated with total mortality. Among the nonvitamin-nonmineral supplements, only glucosamine and chondroitin were associated with total mortality. The hazard ratio (HR) when persons with a high intake of supplements (=/>4 d/wk for =/>3 y) were compared with nonusers was 0.83 (95% CI: 0.72, 0.97; P for trend = 0.009) for glucosamine and 0.83 (95% CI: 0.69, 1.00; P for trend = 0.011) for chondroitin. There was also a suggestion of a decreased risk of total mortality associated with a high intake of fish-oil supplements (HR: 0.83; 95% CI: 0.70, 1.00), but the test for trend was not statistically significant.

Conclusions: For most of the supplements we examined, there was no association with total mortality. Use of glucosamine and use of chondroitin were each associated with decreased total mortality. -- Aalt Pater