Scentific proof that sport stabilize telomere and so slow down aging

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Hi everybody,

in a new study in the journal Cirrculation of the American Heart Association

scientist proof that physical activity regulate proteins

who stabilize the telomere and slows down the erosion of the teleomere

on of the central componets of aging.

DOI 10.1161/CIRCULATIONAHA.109.861005

http://circ.ahajournals.org/cgi/content/abstract/CIRCULATIONAHA.109.861005v1?max\

toshow= & HITS=10 & hits=10 & RESULTFORMAT= & fulltext=109.861005 & searchid=1 & FIRSTINDEX=\

0 & resourcetype=HWCIT

Physical Exercise Prevents Cellular Senescence in Circulating Leukocytes and in

the Vessel Wall

Christian Werner MD, Tobias Fürster MD, Widmann MD, Janine Pöss MD,

Cristiana Roggia MD, Milad Hanhoun MD, Jürgen Scharhag MD, Büchner DBBSc,

Tim Meyer MD, Wilfried Kindermann MD, Judith Haendeler PhD, Böhm MD, and

Ulrich Laufs MD*

From the Klinik für Innere Medizin III, Kardiologie, Angiologie und

Internistische Intensivmedizin (C.W., T.F., J.P., M.H., M.B., U.L.), Klinik für

Innere Medizin I, Onkologie, Hämatologie, Klinische Immunologie und

Rheumatologie (T.W.), and Institut für Pathologie (C.R.), Universitätsklinikum

des Saarlandes, Homburg/Saar, Germany; Institut für Sport und Präventivmedizin,

Universität des Saarlandes, Saarbrücken (J.S., T.M., W.K.); and Institut für

Umweltmedizinische Forschung at the Universität Düsseldorf gGmbH, Düsseldorf

(N.B., J.H.), Germany.

* To whom correspondence should be addressed. E-mail: ulrich@....

Background—The underlying molecular mechanisms of the vasculoprotective effects

of physical exercise are incompletely

understood. Telomere erosion is a central component of aging, and

telomere-associated proteins regulate cellular senescence

and survival. This study examines the effects of exercising on vascular telomere

biology and endothelial apoptosis in mice

and the effects of long-term endurance training on telomere biology in humans.

Methods and Results—C57/Bl6 mice were randomized to voluntary running or no

running wheel conditions for 3 weeks. Exercise upregulated telomerase activity

in the thoracic aorta and in circulating mononuclear cells compared with

sedentary controls, increased vascular expression of telomere repeat-binding

factor 2 and Ku70, and reduced the expression of vascular apoptosis regulators

such as cell-cycle–checkpoint kinase 2, p16, and p53. Mice preconditioned by

voluntary running exhibited a marked reduction in lipopolysaccharide-induced

aortic endothelial apoptosis. Transgenic mouse studies

showed that endothelial nitric oxide synthase and telomerase reverse

transcriptase synergize to confer endothelial stress resistance after physical

activity. To test the significance of these data in humans, telomere biology in

circulating leukocytes of young and middle-aged track and field athletes was

analyzed. Peripheral blood leukocytes isolated from endurance athletes showed

increased telomerase activity, expression of telomere-stabilizing proteins, and

downregulation of cell-cycle inhibitors compared with untrained individuals.

Long-term endurance training was associated with reduced leukocyte telomere

erosion compared with untrained controls.

Conclusions—Physical activity regulates telomere-stabilizing proteins in mice

and in humans and thereby protects from

stress-induced vascular apoptosis.