Re: Scientists find a way to partially reverse aging.

[Guest guest]

It looks like CRON can help protect tolemeres. I am trying to gradually transition over to to a CRON diet. Late onset calorie restriction reduces cellular senescence, protects telomeres

http://www.lef.org/newsletter/2010/0720_Late-Onset-Calorie-Restriction-Reduces-Cellular-Senescence-Protects-Telomeres.htm

On Sun, Nov 28, 2010 at 5:49 PM, Diane W <dianepwalter@...> wrote:

 

" Creating mice with a controllable telomerase switch enabled the scientists to create prematurely aged mice. The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging. "

-Diane

U.S. scientists say they have partially reversed age-related degeneration in mice, leading to new brain and testes growth, improved fertility and the return of lost cognitive function, or thinking skills.

The advance in aging science was achieved by working with telomerase genes in the mice, said the team at the Dana-Farber Cancer Institute in Boston.

The researchers developed mice with a controllable telomerase gene. (Telomerase is an enzyme that helps maintain telomeres -- the protective " caps " on the ends of chromosomes.) As people age, low levels of telomerase lead to progressive erosion and shortening of the telomeres, resulting in physical and mental decline, the study authors explained in a news release from the institute.

Creating mice with a controllable telomerase switch enabled the scientists to create prematurely aged mice. The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging.

In addition, the mice did not show signs of cancer -- a key concern because cancer cells can use telomerase to make themselves virtually immortal. Researchers noted that this is an important area of study for future investigation.

In the future, it may be possible to use this approach to treat people with conditions such as rare genetic premature aging syndromes, in which shortened telomeres play an important role, said study senior author Dr. A. DePinho, director of Dana-Farber's Belfer Institute of Applied Cancer Science.

" Whether this would impact on normal aging is a more difficult question, " he said in the news release. " But it is notable that telomere loss is associated with age-associated disorders and thus restoration of telomeres could alleviate such decline. "

DePinho also said the study may lead to new directions for regenerative medicine because the findings suggest that dormant adult stem cells in extremely aged tissues remain viable and can be reactivated to repair tissue damage.

" If you can remove the underlying damage and stresses that drive the aging process and cause stem cells to go into growth arrest, you may be able to recruit them back into a regenerative response to rejuvenate tissues and maintain health in the aged, " he said in the release.

The study was released online in advance of publication in an upcoming print issue of the journal Nature.

[Guest guest]

According to Walford, starting CRON late in life, the subject of the article below, is a bit trickier and should be moderate (i.e. Do not restrict too much) or it can lead to shorter, not longer life. See page 50 of “Beyond..........” which states: “ The optimal level changes with age, and at greater ages should be less severe”. Walford’s older rats died younger than average when severely restricted.

If you’re just starting CRON, our files especially those aimed at beginners, will help a transition to a CRON diet much easier. Click on “files” in the left hand margin of our website.

On 11/28/10 6:27 PM, " Chuck " <chuckfrasher@...> wrote:

It looks like CRON can help protect tolemeres. I am trying to gradually transition over to to a CRON diet.

Late onset calorie restriction reduces cellular senescence, protects telomeres

http://www.lef.org/newsletter/2010/0720_Late-Onset-Calorie-Restriction-Reduces-Cellular-Senescence-Protects-Telomeres.htm

On Sun, Nov 28, 2010 at 5:49 PM, Diane W <dianepwalter@...> wrote:

 

" Creating mice with a controllable telomerase switch enabled the scientists to create prematurely aged mice. The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging. "

-Diane

U.S. scientists say they have partially reversed age-related degeneration in mice, leading to new brain and testes growth, improved fertility and the return of lost cognitive function, or thinking skills.

The advance in aging science was achieved by working with telomerase genes in the mice, said the team at the Dana-Farber Cancer Institute in Boston.

The researchers developed mice with a controllable telomerase gene. (Telomerase is an enzyme that helps maintain telomeres -- the protective " caps " on the ends of chromosomes.) As people age, low levels of telomerase lead to progressive erosion and shortening of the telomeres, resulting in physical and mental decline, the study authors explained in a news release from the institute.

Creating mice with a controllable telomerase switch enabled the scientists to create prematurely aged mice. The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging.

In addition, the mice did not show signs of cancer -- a key concern because cancer cells can use telomerase to make themselves virtually immortal. Researchers noted that this is an important area of study for future investigation.

In the future, it may be possible to use this approach to treat people with conditions such as rare genetic premature aging syndromes, in which shortened telomeres play an important role, said study senior author Dr. A. DePinho, director of Dana-Farber's Belfer Institute of Applied Cancer Science.

" Whether this would impact on normal aging is a more difficult question, " he said in the news release. " But it is notable that telomere loss is associated with age-associated disorders and thus restoration of telomeres could alleviate such decline. "

DePinho also said the study may lead to new directions for regenerative medicine because the findings suggest that dormant adult stem cells in extremely aged tissues remain viable and can be reactivated to repair tissue damage.

" If you can remove the underlying damage and stresses that drive the aging process and cause stem cells to go into growth arrest, you may be able to recruit them back into a regenerative response to rejuvenate tissues and maintain health in the aged, " he said in the release.

The study was released online in advance of publication in an upcoming print issue of the journal Nature.

[Guest guest]

Here’s the same story on tonight’s national news:

http://abcnews.go.com/Health/Alzheimers/aging-reversed-mice/story?id=12269125

On 11/28/10 5:49 PM, " Diane W " <dianepwalter@...> wrote:

" Creating mice with a controllable telomerase switch enabled the scientists to create prematurely aged mice. The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging. "

-Diane

U.S. scientists say they have partially reversed age-related degeneration in mice, leading to new brain and testes growth, improved fertility and the return of lost cognitive function, or thinking skills.

The advance in aging science was achieved by working with telomerase genes in the mice, said the team at the Dana-Farber Cancer Institute in Boston.

The researchers developed mice with a controllable telomerase gene. (Telomerase is an enzyme that helps maintain telomeres -- the protective " caps " on the ends of chromosomes.) As people age, low levels of telomerase lead to progressive erosion and shortening of the telomeres, resulting in physical and mental decline, the study authors explained in a news release from the institute.

Creating mice with a controllable telomerase switch enabled the scientists to create prematurely aged mice. The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging.

In addition, the mice did not show signs of cancer -- a key concern because cancer cells can use telomerase to make themselves virtually immortal. Researchers noted that this is an important area of study for future investigation.

In the future, it may be possible to use this approach to treat people with conditions such as rare genetic premature aging syndromes, in which shortened telomeres play an important role, said study senior author Dr. A. DePinho, director of Dana-Farber's Belfer Institute of Applied Cancer Science.

" Whether this would impact on normal aging is a more difficult question, " he said in the news release. " But it is notable that telomere loss is associated with age-associated disorders and thus restoration of telomeres could alleviate such decline. "

DePinho also said the study may lead to new directions for regenerative medicine because the findings suggest that dormant adult stem cells in extremely aged tissues remain viable and can be reactivated to repair tissue damage.

" If you can remove the underlying damage and stresses that drive the aging process and cause stem cells to go into growth arrest, you may be able to recruit them back into a regenerative response to rejuvenate tissues and maintain health in the aged, " he said in the release.

The study was released online in advance of publication in an upcoming print issue of the journal Nature.

[Guest guest]

Thank you so much for that. I do remember an interview with Dr. Walford from LEF Magazine a few years back. He did say that if you start later in life that it must be done gradually over a period of months. But I did not recall that diet should be less severely restricted as well. I will read over that again as well as the files. Thanks

On Sun, Nov 28, 2010 at 9:00 PM, Francesca Skelton <fskelton@...> wrote:

 

According to Walford, starting CRON late in life, the subject of the article below, is a bit trickier and should be moderate (i.e. Do not restrict too much) or it can lead to shorter, not longer life.  See page 50 of “Beyond..........” which states:  “ The optimal level changes with age, and at greater ages should be less severe”.  Walford’s older rats died younger than average when severely restricted.

If you’re just starting CRON, our files especially those aimed at beginners, will help a transition to a CRON diet much easier.  Click on “files” in the left hand margin of our website.

On 11/28/10 6:27 PM, " Chuck " <chuckfrasher@...> wrote:

 

 

   

It looks like CRON can help protect tolemeres. I am trying to gradually transition over to to a CRON diet.

Late onset calorie restriction reduces cellular senescence, protects telomeres

http://www.lef.org/newsletter/2010/0720_Late-Onset-Calorie-Restriction-Reduces-Cellular-Senescence-Protects-Telomeres.htm

On Sun, Nov 28, 2010 at 5:49 PM, Diane W <dianepwalter@...> wrote:

 

 

 

   

" Creating mice with a controllable telomerase switch enabled the scientists to create prematurely aged mice. The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging. "

-Diane

U.S. scientists say they have partially reversed age-related degeneration in mice, leading to new brain and testes growth, improved fertility and the return of lost cognitive function, or thinking skills.

The advance in aging science was achieved by working with telomerase genes in the mice, said the team at the Dana-Farber Cancer Institute in Boston.

The researchers developed mice with a controllable telomerase gene. (Telomerase is an enzyme that helps maintain telomeres -- the protective " caps " on the ends of chromosomes.) As people age, low levels of telomerase lead to progressive erosion and shortening of the telomeres, resulting in physical and mental decline, the study authors explained in a news release from the institute.

Creating mice with a controllable telomerase switch enabled the scientists to create prematurely aged mice. The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reduce the signs and symptoms of aging.

In addition, the mice did not show signs of cancer -- a key concern because cancer cells can use telomerase to make themselves virtually immortal. Researchers noted that this is an important area of study for future investigation.

In the future, it may be possible to use this approach to treat people with conditions such as rare genetic premature aging syndromes, in which shortened telomeres play an important role, said study senior author Dr. A. DePinho, director of Dana-Farber's Belfer Institute of Applied Cancer Science.

" Whether this would impact on normal aging is a more difficult question, " he said in the news release. " But it is notable that telomere loss is associated with age-associated disorders and thus restoration of telomeres could alleviate such decline. "

DePinho also said the study may lead to new directions for regenerative medicine because the findings suggest that dormant adult stem cells in extremely aged tissues remain viable and can be reactivated to repair tissue damage.

" If you can remove the underlying damage and stresses that drive the aging process and cause stem cells to go into growth arrest, you may be able to recruit them back into a regenerative response to rejuvenate tissues and maintain health in the aged, " he said in the release.

The study was released online in advance of publication in an upcoming print issue of the journal Nature.

 

   

 

 

   

[Guest guest]

I would imagine that Dr Walford would say:"The switch also enabled the team to determine that reactivating telomerase in the mice could restore telomeres and reducethe signs and symptoms of aging in prematurely aging mice."How did the results compare to normal mice???> > > > > > > > > > > > > "Creating mice with a controllable telomerase switch enabled the scientists to> > create prematurely aged mice. The switch also enabled the team to determine> > that reactivating telomerase in the mice could restore telomeres and reduce> > the signs and symptoms of aging."> > -Diane> > > > U.S. scientists say they have partially reversed age-related degeneration in> > mice, leading to new brain and testes growth, improved fertility and the> > return of lost cognitive function, or thinking skills.> > > > The advance in aging science was achieved by working with telomerase genes in> > the mice, said the team at the Dana-Farber Cancer Institute in Boston.> > > > The researchers developed mice with a controllable telomerase gene.> > (Telomerase is an enzyme that helps maintain telomeres -- the protective> > "caps" on the ends of chromosomes.) As people age, low levels of telomerase> > lead to progressive erosion and shortening of the telomeres, resulting in> > physical and mental decline, the study authors explained in a news release> > from the institute.> > > > Creating mice with a controllable telomerase switch enabled the scientists to> > create prematurely aged mice. The switch also enabled the team to determine> > that reactivating telomerase in the mice could restore telomeres and reduce> > the signs and symptoms of aging.> > > > In addition, the mice did not show signs of cancer -- a key concern because> > cancer cells can use telomerase to make themselves virtually immortal.> > Researchers noted that this is an important area of study for future> > investigation.> > > > In the future, it may be possible to use this approach to treat people with> > conditions such as rare genetic premature aging syndromes, in which shortened> > telomeres play an important role, said study senior author Dr. A.> > DePinho, director of Dana-Farber's Belfer Institute of Applied Cancer Science.> > > > "Whether this would impact on normal aging is a more difficult question," he> > said in the news release. "But it is notable that telomere loss is associated> > with age-associated disorders and thus restoration of telomeres could> > alleviate such decline."> > > > DePinho also said the study may lead to new directions for regenerative> > medicine because the findings suggest that dormant adult stem cells in> > extremely aged tissues remain viable and can be reactivated to repair tissue> > damage.> > > > "If you can remove the underlying damage and stresses that drive the aging> > process and cause stem cells to go into growth arrest, you may be able to> > recruit them back into a regenerative response to rejuvenate tissues and> > maintain health in the aged," he said in the release.> > > > The study was released online in advance of publication in an upcoming print> > issue of the journal Nature.> > > > > > > > > >>