INFO: Drugs That May Cause Liver Dysfunction or Damage

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Heyyyyyyyyyyyy Deb. Thanks for the info. DelDeb <posttransplant@...> wrote: DRUGS THAT MAY CAUSE LIVER DYSFUNCTION OR DAMAGE The liver is the principal organ that is

capable of converting drugs into forms that can be readily eliminated from the body. Given the diversity in use today and the complex burden they impose upon the liver, it is not surprising that a broad spectrum of adverse drug's effects on liver functions and structures has been documented. The reactions range from mild and transient changes in the results of liver function tests to complete liver failure with death of the host. Many drugs may affect the liver adversely in more than one way, as cited below in several listings. The use of the following drugs requires careful monitoring of their effects on the liver during the entire course of treatment. This list is just a general guideline. Many drugs affect the liver to one degree or another and we can't list all of them here; new drugs are always being approved for general use. Read the accompanying literature

with your prescriptions and always consult with your doctor or pharmacist about any new medication if you have liver disease! Drugs that may cause ACUTE DOSE-DEPENDENT LIVER DAMAGE(resembling acute viral hepatitis) acetaminophen salicylates (doses over 2 grams daily) Drugs that may cause ACUTE DOSE-INDEPENDENT LIVER DAMAGE(resembling acute viral hepatitis) acebutolol indomethacin phenylbutazone allopurinol isoniazid phenytoin atenolol ketoconazole piroxicam carbamazepine labetalol probenecid cimetidine maprotiline pyrazinamide dantrolene metoprolol quinidine diclofenac mianserin quinine diltiazem naproxen ranitidine enflurane para-aminosalicylic acid sulfonamides ethambutol penicillins sulindac ethionamide phenelzine tricyclic antidepressants halothane phenindione valproic acid ibuprofen phenobarbital verapamil Drugs that may cause ACUTE FATTY INFILTRATION OF THE LIVER adrenocortical steroids phenothiazines sulfonamides antithyroid drugs phenytoin tetracyclines isoniazid salicylates valproic acid methotrexate Drugs that may cause CHOLESTATIC JAUNDICE actinomycin D chlorpropamide erythromycin amoxicillin/clavulanate cloxacillin flecainide azathioprine cyclophosphamide flurazepam captopril cyclosporine flutamide carbamazepine danazol glyburide

carbimazole diazepam gold cephalosporins disopyramide griseofulvin chlordiazepoxide enalapril enalapril haloperidol ketoconazole norethandrolone sulfonamides mercaptopurine oral contraceptives tamoxifen methyltestosterone oxacillin thiabendazole nifedipine penicillamine tolbutamide nitrofurantoin phenothiazines tricyclic antidepressants nonsteroidal phenytoin troleandomycin anti-inflammatory drugs propoxyphene verapamil Drugs that may cause LIVER GRANULOMAS (chronic inflammatory nodules) allopurinol gold phenytoin aspirin hydralazine procainamide carbamazepine isoniazid quinidine chlorpromazine isoniazid quinidine chlorpromazine nitrofurantoin sulfonamides diltiazem penicillin tolbutamide disopyramide phenylbutazone Drugs that may cause CHRONIC LIVER DISEASE Drugs that may cause active chronic hepatitis acetaminophen (chronic use, large doses) dantrolene methyldopa isoniazid nitrofurantoin Drugs that may cause liver cirrhosis or fibrosis (scarring) methotrexate terbinafine HCI (Lamisil, Sporanox) nicotinic acid Drugs that may cause chronic cholestasis (resembling primary biliary cirrhosis) chlorpromazine/valproic acid (combination) imipramine thiabendazole phenothiazines tolbutamide chlorpropamide/erythro-mycin (combination) phenytoin Drugs that may cause LIVER TUMORS (benign and malignant) anabolic steroids oral contraceptives thorotrast

danazol testosterone Drugs that may cause DAMAGE TO LIVER BLOOD VESSELS adriamycin dacarbazine thioquanine anabolic steroids mercaptopurine vincristine azathioprine methotrexate vitamin A (excessive doses) carmustine mitomycin cyclophosphamide/cyclo-sporine (combination) oral contraceptives Page last updated: March 7, 2003 http://www.hepcnet.net/drugsandliverdamage.html

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Drugs That May Cause Liver Dysfunction or Damage

The liver is the principal organ that is capable of converting drugs into forms that can be readily eliminated from the body. Given the diversity in use today and the complex burden they impose upon the liver, it is not surprising that a

broad spectrum of adverse drugs effects on liver functions and structures has been documented. The reactions range from mild and transient changes in the results of liver function tests to complete liver failure with death of the

host. Many drugs may affect the liver adversely in more than one way, as cited below in several listings. The use of the following drugs requires careful monitoring of their effects on the liver during the entire course of treatment.

Drugs that may cause ACUTE DOSE-DEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acetaminophen salicylates (doses over 2 grams daily)

Drugs that may cause ACUTE DOSE-INDEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acebutolol allopurin atenolol cimetidine dantrolene diclofenac diltiazem enfluraneethambutol ethionamide halothane ibuprofen indomethacin ol labetaloisoniazidketoconazolecarbamazepinemaprotilinemetoprolomianserinnaproxenpara-aminosalicylic acid penicillinsphenelzine phenindionephenobarbital phenylbutazonephenytoin piroxicamprobenecid pyrazinamide quinidinequinineranitidine sulfonamides sulindactricyclic antidepressants valproic acid verapamil

Drugs that may cause ACUTE FATTY INFILTRATION OF THE LIVER

adrenocortical steroids antithyroid drugs isoniazid methotrexate

phenothiazines phenytoinsalicylates

sulfonamides tetracyclines valproic acid

Drugs that may cause CHOLESTATIC JAUNDICE actinomycin Damoxicillin/clavulanate azathioprine captopril carbamazepine carbimazole cephalosporinschlordiazepoxidechlorpropamide cloxacillin cyclophosphamide cyclosporine danazoldiazepamdisopyramide enalapril erythromycinflecainide flurazepamflutamideglyburide goldgriseofulvinhaloperidolketoconazole mercaptopurine methyltestosteronenifedipine nitrofurantoinnorethandrolone nonsteroidal anti-inflammatory drugs oral contraceptives oxacillinpenicillamine phenothiazines phenytoinpropoxyphenesulfonamides tamoxifenthiabendazole tolbutamidetricyclic antidepressantstroleandomycin verapamil

Drugs that may cause LIVER GRANULOMAS (chronic inflammatory nodules)allopurinol aspirin carbamazepinechlorpromazine diltiazemdisopyramide gold hydralazineisoniazid nitrofurantoin penicillin phenylbutazone phenytoinprocainamidequinidinesulfonamidestolbutamide

Drugs that may cause active chronic hepatitisacetaminophenuisoniazid dantrolene nitrofurantoin methyldopa

Drugs that may cause liver cirrhosis or fibrosis (scarring) methotrexate nicotinic acid

Drugs that may cause chronic cholestasis (resembling primary biliary cirrhosis) chlorpromazine/valproic acid (combination)chlorpropamide/erythromycin (combination)imipramine phenothiazinesphenytointhiabendazoletolbutamide

Drugs that may cause LIVER TUMORS (benign and malignant) anabolic steroids danazoloral contraceptives thorotrasttestosterone

Drugs that may cause DAMAGE TO LIVER BLOOD VESSELSadriamycinanabolic steroids azathioprine carmustine cyclophosphamide/cyclosporine (combination) dacarbazine mercaptopurinemethotrexate mitomycinoral contraceptives thioquaninevincristinevitamin A (excessive doses) SOURCE: The Essential Guide to Prescription Drugs, by W. Long and J. Rybacki. ISBN 0-06-273211-0

[Guest guest]

Deb ~~

Thanks for sending this. I will tuck it away to compare with any future medications that may be prescribed for me. I appreciate it.

From: Deb <posttransplant@...>Subject: INFO: Drugs That May Cause Liver Dysfunction or DamageHepatitis Cfordummies Date: Wednesday, July 23, 2008, 12:17 PM

Drugs That May Cause Liver Dysfunction or Damage

The liver is the principal organ that is capable of converting drugs into forms that can be readily eliminated from the body. Given the diversity in use today and the complex burden they impose upon the liver, it is not surprising that a

broad spectrum of adverse drugs effects on liver functions and structures has been documented. The reactions range from mild and transient changes in the results of liver function tests to complete liver failure with death of the

host. Many drugs may affect the liver adversely in more than one way, as cited below in several listings. The use of the following drugs requires careful monitoring of their effects on the liver during the entire course of treatment.

Drugs that may cause ACUTE DOSE-DEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acetaminophen salicylates (doses over 2 grams daily)

Drugs that may cause ACUTE DOSE-INDEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acebutolol allopurin atenolol cimetidine dantrolene diclofenac diltiazem enfluraneethambutol ethionamide halothane ibuprofen indomethacin ol labetaloisoniazidketoconazolecarbamazepinemaprotilinemetoprolomianserinnaproxenpara-aminosalicylic acid penicillinsphenelzine phenindionephenobarbital phenylbutazonephenytoin piroxicamprobenecid pyrazinamide quinidinequinineranitidine sulfonamides sulindactricyclic antidepressants valproic acid verapamil

Drugs that may cause ACUTE FATTY INFILTRATION OF THE LIVER

adrenocortical steroids antithyroid drugs isoniazid methotrexate

phenothiazines phenytoinsalicylates

sulfonamides tetracyclines valproic acid

Drugs that may cause CHOLESTATIC JAUNDICE actinomycin Damoxicillin/ clavulanate azathioprine captopril carbamazepine carbimazole cephalosporinschlordiazepoxidechl orpropamide cloxacillin cyclophosphamide cyclosporine danazoldiazepamdisopyramide enalapril erythromycinflecainide flurazepamflutamideglyburide goldgriseofulvinhaloperidolketoconazole mercaptopurine methyltestosteronenifedipine nitrofurantoinnorethandrolone nonsteroidal anti-inflammatory drugs oral contraceptives oxacillinpenicillamine phenothiazines phenytoinpropoxyphenesulfonamides tamoxifenthiabendazole tolbutamidetricyclic antidepressantstroleandomycin verapamil

Drugs that may cause LIVER GRANULOMAS (chronic inflammatory nodules)allopurinol aspirin carbamazepinechlorpromazine diltiazemdisopyramide gold hydralazineisoniazid nitrofurantoin penicillin phenylbutazone phenytoinprocainamidequinidinesulfonamidestolbutamide

Drugs that may cause active chronic hepatitisacetaminophenuisoniazid dantrolene nitrofurantoin methyldopa

Drugs that may cause liver cirrhosis or fibrosis (scarring) methotrexate nicotinic acid

Drugs that may cause chronic cholestasis (resembling primary biliary cirrhosis) chlorpromazine/ valproic acid (combination)chlorpropamide/ erythromycin (combination)imipramine phenothiazinesphenytointhiabendazoletolbutamide

Drugs that may cause LIVER TUMORS (benign and malignant) anabolic steroids danazoloral contraceptives thorotrasttestosterone

Drugs that may cause DAMAGE TO LIVER BLOOD VESSELSadriamycinanabolic steroids azathioprine carmustine cyclophosphamide/ cyclosporine (combination) dacarbazine mercaptopurinemethotrexate mitomycinoral contraceptives thioquaninevincristinevitamin A (excessive doses) SOURCE: The Essential Guide to Prescription Drugs, by W. Long and J. Rybacki. ISBN 0-06-273211- 0

[Guest guest]

Deb ~~

Thanks for sending this. I will tuck it away to compare with any future medications that may be prescribed for me. I appreciate it.

From: Deb <posttransplant@...>Subject: INFO: Drugs That May Cause Liver Dysfunction or DamageHepatitis Cfordummies Date: Wednesday, July 23, 2008, 12:17 PM

Drugs That May Cause Liver Dysfunction or Damage

The liver is the principal organ that is capable of converting drugs into forms that can be readily eliminated from the body. Given the diversity in use today and the complex burden they impose upon the liver, it is not surprising that a

broad spectrum of adverse drugs effects on liver functions and structures has been documented. The reactions range from mild and transient changes in the results of liver function tests to complete liver failure with death of the

host. Many drugs may affect the liver adversely in more than one way, as cited below in several listings. The use of the following drugs requires careful monitoring of their effects on the liver during the entire course of treatment.

Drugs that may cause ACUTE DOSE-DEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acetaminophen salicylates (doses over 2 grams daily)

Drugs that may cause ACUTE DOSE-INDEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acebutolol allopurin atenolol cimetidine dantrolene diclofenac diltiazem enfluraneethambutol ethionamide halothane ibuprofen indomethacin ol labetaloisoniazidketoconazolecarbamazepinemaprotilinemetoprolomianserinnaproxenpara-aminosalicylic acid penicillinsphenelzine phenindionephenobarbital phenylbutazonephenytoin piroxicamprobenecid pyrazinamide quinidinequinineranitidine sulfonamides sulindactricyclic antidepressants valproic acid verapamil

Drugs that may cause ACUTE FATTY INFILTRATION OF THE LIVER

adrenocortical steroids antithyroid drugs isoniazid methotrexate

phenothiazines phenytoinsalicylates

sulfonamides tetracyclines valproic acid

Drugs that may cause CHOLESTATIC JAUNDICE actinomycin Damoxicillin/ clavulanate azathioprine captopril carbamazepine carbimazole cephalosporinschlordiazepoxidechl orpropamide cloxacillin cyclophosphamide cyclosporine danazoldiazepamdisopyramide enalapril erythromycinflecainide flurazepamflutamideglyburide goldgriseofulvinhaloperidolketoconazole mercaptopurine methyltestosteronenifedipine nitrofurantoinnorethandrolone nonsteroidal anti-inflammatory drugs oral contraceptives oxacillinpenicillamine phenothiazines phenytoinpropoxyphenesulfonamides tamoxifenthiabendazole tolbutamidetricyclic antidepressantstroleandomycin verapamil

Drugs that may cause LIVER GRANULOMAS (chronic inflammatory nodules)allopurinol aspirin carbamazepinechlorpromazine diltiazemdisopyramide gold hydralazineisoniazid nitrofurantoin penicillin phenylbutazone phenytoinprocainamidequinidinesulfonamidestolbutamide

Drugs that may cause active chronic hepatitisacetaminophenuisoniazid dantrolene nitrofurantoin methyldopa

Drugs that may cause liver cirrhosis or fibrosis (scarring) methotrexate nicotinic acid

Drugs that may cause chronic cholestasis (resembling primary biliary cirrhosis) chlorpromazine/ valproic acid (combination)chlorpropamide/ erythromycin (combination)imipramine phenothiazinesphenytointhiabendazoletolbutamide

Drugs that may cause LIVER TUMORS (benign and malignant) anabolic steroids danazoloral contraceptives thorotrasttestosterone

Drugs that may cause DAMAGE TO LIVER BLOOD VESSELSadriamycinanabolic steroids azathioprine carmustine cyclophosphamide/ cyclosporine (combination) dacarbazine mercaptopurinemethotrexate mitomycinoral contraceptives thioquaninevincristinevitamin A (excessive doses) SOURCE: The Essential Guide to Prescription Drugs, by W. Long and J. Rybacki. ISBN 0-06-273211- 0

[Guest guest]

Deb ~~

Thanks for sending this. I will tuck it away to compare with any future medications that may be prescribed for me. I appreciate it.

From: Deb <posttransplant@...>Subject: INFO: Drugs That May Cause Liver Dysfunction or DamageHepatitis Cfordummies Date: Wednesday, July 23, 2008, 12:17 PM

Drugs That May Cause Liver Dysfunction or Damage

The liver is the principal organ that is capable of converting drugs into forms that can be readily eliminated from the body. Given the diversity in use today and the complex burden they impose upon the liver, it is not surprising that a

broad spectrum of adverse drugs effects on liver functions and structures has been documented. The reactions range from mild and transient changes in the results of liver function tests to complete liver failure with death of the

host. Many drugs may affect the liver adversely in more than one way, as cited below in several listings. The use of the following drugs requires careful monitoring of their effects on the liver during the entire course of treatment.

Drugs that may cause ACUTE DOSE-DEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acetaminophen salicylates (doses over 2 grams daily)

Drugs that may cause ACUTE DOSE-INDEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acebutolol allopurin atenolol cimetidine dantrolene diclofenac diltiazem enfluraneethambutol ethionamide halothane ibuprofen indomethacin ol labetaloisoniazidketoconazolecarbamazepinemaprotilinemetoprolomianserinnaproxenpara-aminosalicylic acid penicillinsphenelzine phenindionephenobarbital phenylbutazonephenytoin piroxicamprobenecid pyrazinamide quinidinequinineranitidine sulfonamides sulindactricyclic antidepressants valproic acid verapamil

Drugs that may cause ACUTE FATTY INFILTRATION OF THE LIVER

adrenocortical steroids antithyroid drugs isoniazid methotrexate

phenothiazines phenytoinsalicylates

sulfonamides tetracyclines valproic acid

Drugs that may cause CHOLESTATIC JAUNDICE actinomycin Damoxicillin/ clavulanate azathioprine captopril carbamazepine carbimazole cephalosporinschlordiazepoxidechl orpropamide cloxacillin cyclophosphamide cyclosporine danazoldiazepamdisopyramide enalapril erythromycinflecainide flurazepamflutamideglyburide goldgriseofulvinhaloperidolketoconazole mercaptopurine methyltestosteronenifedipine nitrofurantoinnorethandrolone nonsteroidal anti-inflammatory drugs oral contraceptives oxacillinpenicillamine phenothiazines phenytoinpropoxyphenesulfonamides tamoxifenthiabendazole tolbutamidetricyclic antidepressantstroleandomycin verapamil

Drugs that may cause LIVER GRANULOMAS (chronic inflammatory nodules)allopurinol aspirin carbamazepinechlorpromazine diltiazemdisopyramide gold hydralazineisoniazid nitrofurantoin penicillin phenylbutazone phenytoinprocainamidequinidinesulfonamidestolbutamide

Drugs that may cause active chronic hepatitisacetaminophenuisoniazid dantrolene nitrofurantoin methyldopa

Drugs that may cause liver cirrhosis or fibrosis (scarring) methotrexate nicotinic acid

Drugs that may cause chronic cholestasis (resembling primary biliary cirrhosis) chlorpromazine/ valproic acid (combination)chlorpropamide/ erythromycin (combination)imipramine phenothiazinesphenytointhiabendazoletolbutamide

Drugs that may cause LIVER TUMORS (benign and malignant) anabolic steroids danazoloral contraceptives thorotrasttestosterone

Drugs that may cause DAMAGE TO LIVER BLOOD VESSELSadriamycinanabolic steroids azathioprine carmustine cyclophosphamide/ cyclosporine (combination) dacarbazine mercaptopurinemethotrexate mitomycinoral contraceptives thioquaninevincristinevitamin A (excessive doses) SOURCE: The Essential Guide to Prescription Drugs, by W. Long and J. Rybacki. ISBN 0-06-273211- 0

[Guest guest]

I printed out a copy for myself too.It is a handy list.Thanks Deb.

Gail

INFO: Drugs That May Cause Liver Dysfunction or DamageHepatitis Cfordummies Date: Wednesday, July 23, 2008, 12:17 PM

Drugs That May Cause Liver Dysfunction or Damage

The liver is the principal organ that is capable of converting drugs into forms that can be readily eliminated from the body. Given the diversity in use today and the complex burden they impose upon the liver, it is not surprising that a

broad spectrum of adverse drugs effects on liver functions and structures has been documented. The reactions range from mild and transient changes in the results of liver function tests to complete liver failure with death of the

host. Many drugs may affect the liver adversely in more than one way, as cited below in several listings. The use of the following drugs requires careful monitoring of their effects on the liver during the entire course of treatment.

Drugs that may cause ACUTE DOSE-DEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acetaminophen salicylates (doses over 2 grams daily)

Drugs that may cause ACUTE DOSE-INDEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acebutolol allopurin atenolol cimetidine dantrolene diclofenac diltiazem enfluraneethambutol ethionamide halothane ibuprofen indomethacin ol labetaloisoniazidketoconazolecarbamazepinemaprotilinemetoprolomianserinnaproxenpara-aminosalicylic acid penicillinsphenelzine phenindionephenobarbital phenylbutazonephenytoin piroxicamprobenecid pyrazinamide quinidinequinineranitidine sulfonamides sulindactricyclic antidepressants valproic acid verapamil

Drugs that may cause ACUTE FATTY INFILTRATION OF THE LIVER

adrenocortical steroids antithyroid drugs isoniazid methotrexate

phenothiazines phenytoinsalicylates

sulfonamides tetracyclines valproic acid

Drugs that may cause CHOLESTATIC JAUNDICE actinomycin Damoxicillin/ clavulanate azathioprine captopril carbamazepine carbimazole cephalosporinschlordiazepoxidechl orpropamide cloxacillin cyclophosphamide cyclosporine danazoldiazepamdisopyramide enalapril erythromycinflecainide flurazepamflutamideglyburide goldgriseofulvinhaloperidolketoconazole mercaptopurine methyltestosteronenifedipine nitrofurantoinnorethandrolone nonsteroidal anti-inflammatory drugs oral contraceptives oxacillinpenicillamine phenothiazines phenytoinpropoxyphenesulfonamides tamoxifenthiabendazole tolbutamidetricyclic antidepressantstroleandomycin verapamil

Drugs that may cause LIVER GRANULOMAS (chronic inflammatory nodules)allopurinol aspirin carbamazepinechlorpromazine diltiazemdisopyramide gold hydralazineisoniazid nitrofurantoin penicillin phenylbutazone phenytoinprocainamidequinidinesulfonamidestolbutamide

Drugs that may cause active chronic hepatitisacetaminophenuisoniazid dantrolene nitrofurantoin methyldopa

Drugs that may cause liver cirrhosis or fibrosis (scarring) methotrexate nicotinic acid

Drugs that may cause chronic cholestasis (resembling primary biliary cirrhosis) chlorpromazine/ valproic acid (combination)chlorpropamide/ erythromycin (combination)imipramine phenothiazinesphenytointhiabendazoletolbutamide

Drugs that may cause LIVER TUMORS (benign and malignant) anabolic steroids danazoloral contraceptives thorotrasttestosterone

Drugs that may cause DAMAGE TO LIVER BLOOD VESSELSadriamycinanabolic steroids azathioprine carmustine cyclophosphamide/ cyclosporine (combination) dacarbazine mercaptopurinemethotrexate mitomycinoral contraceptives thioquaninevincristinevitamin A (excessive doses) SOURCE: The Essential Guide to Prescription Drugs, by W. Long and J. Rybacki. ISBN 0-06-273211- 0

[Guest guest]

Subject: INFO: Drugs That May Cause Liver Dysfunction or DamageTo: hepatitiscsupportgroupfordummies Date: Wednesday, July 23, 2008, 12:17 PM

Drugs That May Cause Liver Dysfunction or Damage

The liver is the principal organ that is capable of converting drugs into forms that can be readily eliminated from the body. Given the diversity in use today and the complex burden they impose upon the liver, it is not surprising that a

broad spectrum of adverse drugs effects on liver functions and structures has been documented. The reactions range from mild and transient changes in the results of liver function tests to complete liver failure with death of the

host. Many drugs may affect the liver adversely in more than one way, as cited below in several listings. The use of the following drugs requires careful monitoring of their effects on the liver during the entire course of treatment.

Drugs that may cause ACUTE DOSE-DEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acetaminophen salicylates (doses over 2 grams daily)

Drugs that may cause ACUTE DOSE-INDEPENDENT LIVER DAMAGE (resembling acute viral hepatitis)

acebutolol allopurin atenolol cimetidine dantrolene diclofenac diltiazem enfluraneethambutol ethionamide halothane ibuprofen indomethacin ol labetaloisoniazidketoconazolecarbamazepinemaprotilinemetoprolomianserinnaproxenpara-aminosalicylic acid penicillinsphenelzine phenindionephenobarbital phenylbutazonephenytoin piroxicamprobenecid pyrazinamide quinidinequinineranitidine sulfonamides sulindactricyclic antidepressants valproic acid verapamil

Drugs that may cause ACUTE FATTY INFILTRATION OF THE LIVER

adrenocortical steroids antithyroid drugs isoniazid methotrexate

phenothiazines phenytoinsalicylates

sulfonamides tetracyclines valproic acid

Drugs that may cause CHOLESTATIC JAUNDICE actinomycin Damoxicillin/clavulanate azathioprine captopril carbamazepine carbimazole cephalosporinschlordiazepoxidechlorpropamide cloxacillin cyclophosphamide cyclosporine danazoldiazepamdisopyramide enalapril erythromycinflecainide flurazepamflutamideglyburide goldgriseofulvinhaloperidolketoconazole mercaptopurine methyltestosteronenifedipine nitrofurantoinnorethandrolone nonsteroidal anti-inflammatory drugs oral contraceptives oxacillinpenicillamine phenothiazines phenytoinpropoxyphenesulfonamides tamoxifenthiabendazole tolbutamidetricyclic antidepressantstroleandomycin verapamil

Drugs that may cause LIVER GRANULOMAS (chronic inflammatory nodules)allopurinol aspirin carbamazepinechlorpromazine diltiazemdisopyramide gold hydralazineisoniazid nitrofurantoin penicillin phenylbutazone phenytoinprocainamidequinidinesulfonamidestolbutamide

Drugs that may cause active chronic hepatitisacetaminophenuisoniazid dantrolene nitrofurantoin methyldopa

Drugs that may cause liver cirrhosis or fibrosis (scarring) methotrexate nicotinic acid

Drugs that may cause chronic cholestasis (resembling primary biliary cirrhosis) chlorpromazine/valproic acid (combination)chlorpropamide/erythromycin (combination)imipramine phenothiazinesphenytointhiabendazoletolbutamide

Drugs that may cause LIVER TUMORS (benign and malignant) anabolic steroids danazoloral contraceptives thorotrasttestosterone

Drugs that may cause DAMAGE TO LIVER BLOOD VESSELSadriamycinanabolic steroids azathioprine carmustine cyclophosphamide/cyclosporine (combination) dacarbazine mercaptopurinemethotrexate mitomycinoral contraceptives thioquaninevincristinevitamin A (excessive doses) SOURCE: The Essential Guide to Prescription Drugs, by W. Long and J. Rybacki. ISBN 0-06-273211-0