Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 The first time I took spiro it did work wonders for my adult-onset cystic acne. The second time it made it far worse. Go figure! Both times gave me debilitating breast pain so I didn't last long on it. My doctor believes that the reason that it's not more common knowledge that the side effects of spiro can be equally bad for both sexes is that " most " women LOVE the side effect of bigger boobs so much that they are willing to put up with the side effects - your comment about the " glowing feedback " further confirms this. I've always been very content to be petite all over, so I simply cannot fathom this thinking! > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > Source > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > Abstract > > > > BACKGROUND: > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > OBJECTIVES: > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > METHODS: > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > RESULTS: > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > CONCLUSIONS: > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 Plastic surgeons make millions and billions from making them bigger so most don't share your non-enthusiasm for their growth. As a male, if the pain that I felt is the same for a woman I can't imagine a little growth being worth it though. I can only describe it as feeling like I had rocks under my nipples and bumping my chest into anything was intensely painful. , 2/2/12, msmith_1928 <janeray1940@...> wrote: From: msmith_1928 <janeray1940@...>Subject: Re: women and spirohyperaldosteronism Date: Thursday, February 2, 2012, 12:28 PM The first time I took spiro it did work wonders for my adult-onset cystic acne. The second time it made it far worse. Go figure! Both times gave me debilitating breast pain so I didn't last long on it.My doctor believes that the reason that it's not more common knowledge that the side effects of spiro can be equally bad for both sexes is that "most" women LOVE the side effect of bigger boobs so much that they are willing to put up with the side effects - your comment about the "glowing feedback" further confirms this. I've always been very content to be petite all over, so I simply cannot fathom this thinking!> >> > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848> > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans.> > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > Source> > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@> > Abstract> > > > BACKGROUND: > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias.> > > > OBJECTIVES: > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels.> > > > METHODS: > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year.> > > > RESULTS: > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups.> > > > CONCLUSIONS: > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels.> > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX.> > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD.> > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS.> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 Sounds like similar pain. The pain for me made it impossible to sleep on my side or belly, hug anybody, carry things in front of me, hike downhill, hit a bump in the road while driving, or do certain yoga asanas, without bringing a tear to my eye. Sometimes I'd get a sort of burning pain while doing nothing at all, it was just this constant dull ache. > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > Source > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > Abstract > > > > > > BACKGROUND: > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > OBJECTIVES: > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > METHODS: > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > RESULTS: > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > CONCLUSIONS: > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 I agree there is nothing sexy about engorged breasts 365 days a year. I am on Inspra and I am having this problem. It is very painful and making it hard to fit into my clothes. I also have to wonder about will this lead to breast cancer. Phyllis > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > Source > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > Abstract > > > > > > BACKGROUND: > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > OBJECTIVES: > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > METHODS: > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > RESULTS: > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > CONCLUSIONS: > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 I used to work with a lady who had 42 lbs. removed! She had " glowing feedback " and no more backache! > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > Source > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > Abstract > > > > > > BACKGROUND: > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > OBJECTIVES: > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > METHODS: > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > RESULTS: > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > CONCLUSIONS: > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 Are you getting it on Inspra? I thought that wasn't supposed to happen. > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > Source > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > Abstract > > > > > > > > BACKGROUND: > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > OBJECTIVES: > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > METHODS: > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > RESULTS: > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > CONCLUSIONS: > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 For the record, I've been on spiro for probably 10 years and never had any problems. I've never had sore or engorged boobs and I'm sure I'm not the only one. From: <jclark24p@...> hyperaldosteronism Sent: Thursday, February 2, 2012 3:34 PM Subject: Re: women and spiro Are you getting it on Inspra? I thought that wasn't supposed to happen. > > > >> > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848> > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans.> > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > Source> > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@> > > > Abstract> > > > > > > > BACKGROUND: > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias.> > > > > > > > OBJECTIVES: > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels.> > > > > > > > METHODS: > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year.> > > > > > > > RESULTS: > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups.> > > > > > > > CONCLUSIONS: > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels.> > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX.> > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD.> > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS.> > > >> > >> >>------------------------------------ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 Looking at engorged breasts 365 days a year as beiong sexy is certainly open to interpretation and the eye of the beholder. Wearing them or touching them may be another story From: <jclark24p@...>Subject: Re: women and spirohyperaldosteronism Date: Thursday, February 2, 2012, 2:34 PM Are you getting it on Inspra? I thought that wasn't supposed to happen. > > > >> > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848> > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans.> > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > Source> > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@> > > > Abstract> > > > > > > > BACKGROUND: > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias.> > > > > > > > OBJECTIVES: > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels.> > > > > > > > METHODS: > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year.> > > > > > > > RESULTS: > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups.> > > > > > > > CONCLUSIONS: > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels.> > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX.> > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD.> > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS.> > > >> > >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 Drug information doesn't say you can't get it just not as many get it. It is possable to get it .04% of the time. > > > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > > Source > > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > > Abstract > > > > > > > > > > BACKGROUND: > > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > > > OBJECTIVES: > > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > > > METHODS: > > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > > > RESULTS: > > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > > > CONCLUSIONS: > > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 a, good for you. It is no fun. Phyllis On 2/2/2012 3:41 PM, a Hall wrote: For the record, I've been on spiro for probably 10 years and never had any problems. I've never had sore or engorged boobs and I'm sure I'm not the only one. From: <jclark24p@...> To: hyperaldosteronism Sent: Thursday, February 2, 2012 3:34 PM Subject: Re: women and spiro Are you getting it on Inspra? I thought that wasn't supposed to happen. > > I agree there is nothing sexy about engorged breasts 365 days a year. > I am on Inspra and I am having this problem. It is very painful and making it hard to fit into my clothes. I also have to wonder about will this lead to breast cancer. > > Phyllis > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 You wouldn't beholding mine if they were sore (but they are not, that's why they wouldn't approve a switch!) I was in the store the other day and I was talking with a friend when his wife came up. She figured out what we were talking about and said, " You've got boobs, can I see them? " I said " Sure, right after I see your's! " Didn't happen! I then told her if she really wanted to see the effect she should look a little lower - that's when she started to cry! Trust me, the growth is NOT proportional to the reduction! :>( > > > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > > Source > > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > > Abstract > > > > > > > > > > BACKGROUND: > > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > > > OBJECTIVES: > > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > > > METHODS: > > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > > > RESULTS: > > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > > > CONCLUSIONS: > > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012  Just rocks? Not hot rocks? Mine would spontaneously combust in the first month of breast feeding. Barb Re: women and spirohyperaldosteronism Date: Thursday, February 2, 2012, 12:28 PM The first time I took spiro it did work wonders for my adult-onset cystic acne. The second time it made it far worse. Go figure! Both times gave me debilitating breast pain so I didn't last long on it.My doctor believes that the reason that it's not more common knowledge that the side effects of spiro can be equally bad for both sexes is that "most" women LOVE the side effect of bigger boobs so much that they are willing to put up with the side effects - your comment about the "glowing feedback" further confirms this. I've always been very content to be petite all over, so I simply cannot fathom this thinking!> >> > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848> > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans.> > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > Source> > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@> > Abstract> > > > BACKGROUND: > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias.> > > > OBJECTIVES: > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels.> > > > METHODS: > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year.> > > > RESULTS: > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups.> > > > CONCLUSIONS: > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels.> > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX.> > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD.> > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS.> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 How does tht compare with a placebo? That's quite different than something between 5.9 and 50+% depending on dosage with Spiro. (Don't hold me to those number, they are close but may not be exact.) Now, before you ladies get your " hate pens " out, I'd carry 3 boobs around before I would willingly endure the side effects some of you describe! > > > > > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > > > Source > > > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > > > Abstract > > > > > > > > > > > > BACKGROUND: > > > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > > > > > OBJECTIVES: > > > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > > > > > METHODS: > > > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > > > > > RESULTS: > > > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > > > > > CONCLUSIONS: > > > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 Depends on what chart you look at. you can see more here. http://www.drugs.com/pro/inspra.html > > > > > > > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > > > > Source > > > > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > > > > Abstract > > > > > > > > > > > > > > BACKGROUND: > > > > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > > > > > > > OBJECTIVES: > > > > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > > > > > > > METHODS: > > > > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > > > > > > > RESULTS: > > > > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > > > > > > > CONCLUSIONS: > > > > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 I thought we were specifically talking about the sexual hormone side effects, gynecomastia and menstrual irregularities. I don't have much experience in menstrual irregularities but IMHO 4 in 10,000 (or 1 in 2,500 ) might be " normal " or darn close to it! > > > > > > > > > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > > > > > Source > > > > > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > > > > > Abstract > > > > > > > > > > > > > > > > BACKGROUND: > > > > > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > > > > > > > > > OBJECTIVES: > > > > > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > > > > > > > > > METHODS: > > > > > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > > > > > > > > > RESULTS: > > > > > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > > > > > > > > > CONCLUSIONS: > > > > > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 Note it says Gynecomastia and abnormal vaginal bleeding were reported with Inspra but not with placebo. To me it mean it was abnormal on Inspra. I thought we were talking about it causing engorged breasts. > > > > > > > > > > > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > > > > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > > > > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > > > > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > > > > > > Source > > > > > > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > > > > > > Abstract > > > > > > > > > > > > > > > > > > BACKGROUND: > > > > > > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > > > > > > > > > > > OBJECTIVES: > > > > > > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > > > > > > > > > > > METHODS: > > > > > > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > > > > > > > > > > > RESULTS: > > > > > > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > > > > > > > > > > > CONCLUSIONS: > > > > > > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > > > > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > > > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > > > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 Not likely due to inspra they say. What else are or we're u taking before inspra. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Feb 2, 2012, at 12:08, phylisrn <phylisrn@...> wrote: I agree there is nothing sexy about engorged breasts 365 days a year. I am on Inspra and I am having this problem. It is very painful and making it hard to fit into my clothes. I also have to wonder about will this lead to breast cancer. Phyllis > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > Source > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > Abstract > > > > > > BACKGROUND: > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > OBJECTIVES: > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > METHODS: > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > RESULTS: > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > CONCLUSIONS: > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 32 lbs of what?May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Feb 2, 2012, at 12:25, <jclark24p@...> wrote: I used to work with a lady who had 42 lbs. removed! She had "glowing feedback" and no more backache! > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > Source > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > Abstract > > > > > > BACKGROUND: > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > OBJECTIVES: > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > METHODS: > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > RESULTS: > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > CONCLUSIONS: > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 If u read the article on genetic aldo u will note several of the affected have been on Spiro for up to 30 years. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Feb 2, 2012, at 12:41, a Hall <shahall@...> wrote: For the record, I've been on spiro for probably 10 years and never had any problems. I've never had sore or engorged boobs and I'm sure I'm not the only one. From: <jclark24p@...> hyperaldosteronism Sent: Thursday, February 2, 2012 3:34 PM Subject: Re: women and spiro Are you getting it on Inspra? I thought that wasn't supposed to happen. > > > >> > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848> > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans.> > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > Source> > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@> > > > Abstract> > > > > > > > BACKGROUND: > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias.> > > > > > > > OBJECTIVES: > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels.> > > > > > > > METHODS: > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year.> > > > > > > > RESULTS: > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups.> > > > > > > > CONCLUSIONS: > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels.> > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX.> > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD.> > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS.> > > >> > >> >>------------------------------------ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 And how many on placebo got it?May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Feb 2, 2012, at 12:48, Francis Bill SUSPECTED PA <georgewbill@...> wrote: Drug information doesn't say you can't get it just not as many get it. It is possable to get it .04% of the time. > > > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > > Source > > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > > Abstract > > > > > > > > > > BACKGROUND: > > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > > > OBJECTIVES: > > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > > > METHODS: > > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > > > RESULTS: > > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > > > CONCLUSIONS: > > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 Thought we were talking about epleroMay your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Feb 2, 2012, at 13:49, <jclark24p@...> wrote: How does tht compare with a placebo? That's quite different than something between 5.9 and 50+% depending on dosage with Spiro. (Don't hold me to those number, they are close but may not be exact.) Now, before you ladies get your "hate pens" out, I'd carry 3 boobs around before I would willingly endure the side effects some of you describe! > > > > > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > > > Source > > > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > > > Abstract > > > > > > > > > > > > BACKGROUND: > > > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > > > > > OBJECTIVES: > > > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > > > > > METHODS: > > > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > > > > > RESULTS: > > > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > > > > > CONCLUSIONS: > > > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 2, 2012 Report Share Posted February 2, 2012 And how many we're in the study that make up the study. Most drugs are approved after testing on fewer than 10,000 folks carefully selected to be not very sick. So what is probability that a side effect that the drug kills one in 25000 will be detected In a 10000 person study?May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Feb 2, 2012, at 17:08, Francis Bill SUSPECTED PA <georgewbill@...> wrote: Note it says Gynecomastia and abnormal vaginal bleeding were reported with Inspra but not with placebo. To me it mean it was abnormal on Inspra. I thought we were talking about it causing engorged breasts. > > > > > > > > > > > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > > > > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > > > > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > > > > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > > > > > > Source > > > > > > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > > > > > > Abstract > > > > > > > > > > > > > > > > > > BACKGROUND: > > > > > > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > > > > > > > > > > > OBJECTIVES: > > > > > > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > > > > > > > > > > > METHODS: > > > > > > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > > > > > > > > > > > RESULTS: > > > > > > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > > > > > > > > > > > CONCLUSIONS: > > > > > > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > > > > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > > > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > > > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 3, 2012 Report Share Posted February 3, 2012 Hi Just to share my experience - I've been on spiro for about 4 months. Had terrible breast pain to start with (just like the pain I had at the very beginning of my first pregnancy)but it's now gone. I also had disrupted menstruation - that may have settled now but I probably need another 6 months to be sure. My 'slight hirsutism' (my consultant's words) has stayed the same. Terri (recently diagnosed with PA after about 10 years of unexplained high blood pressure which started when I was about 30) Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 3, 2012 Report Share Posted February 3, 2012 We were talking about gynecomstia and the frequency of occurance (note the subject)! > > > > > > > > > > > > > > > > Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of Spironolactone! > > > > > > > > > > > > > > > > Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848 > > > > > > > > > > > > > > > > Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia: a prospective cohort study of Air Force veterans. > > > > > > > > > > > > > > > > Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE. > > > > > > > > Source > > > > > > > > The University of Texas School of Public Health, Regional Campus at Dallas, Dallas, Texas 75390-9110, USA. amit.gupta@ > > > > > > > > Abstract > > > > > > > > > > > > > > > > BACKGROUND: > > > > > > > > Operation Ranch Hand veterans were involved in spraying herbicides, including Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that dioxins may be partially responsible for an increase of male reproductive tract disorders such as testicular cancer, cryptorchidism, and hypospadias. > > > > > > > > > > > > > > > > OBJECTIVES: > > > > > > > > In this study, our objective was to assess the effect of serum TCDD concentration on the risk of development of benign prostatic hyperplasia (BPH) and on serum testosterone levels. > > > > > > > > > > > > > > > > METHODS: > > > > > > > > This study was a longitudinal, prospective cohort study made up of U.S. Air Force veterans involved in Operation Ranch Hand. Other Air Force veterans who did not spray herbicides were included as comparisons. BPH was determined by medical record review and by medical examinations conducted during the study. Data were available for 971 Ranch Hand and 1,266 comparison veterans. We investigated the relationship between BPH and serum TCDD level using the proportional hazards models adjusted for testosterone levels, body mass index (BMI), and the percentage change in BMI per year. > > > > > > > > > > > > > > > > RESULTS: > > > > > > > > In univariate and multivariate analyses, the risk of BPH decreased with increasing serum TCDD in the comparison group. The multivariate risk ratio for BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98). Excluding men with prostate cancer, inflammatory or other prostatic diseases did not substantially alter the association. Serum testosterone levels were inversely associated with serum TCDD levels in both Ranch Hand and comparison groups. > > > > > > > > > > > > > > > > CONCLUSIONS: > > > > > > > > TCDD exposure at general population levels is associated with a decreasing risk of BPH with higher exposure levels. TCDD exposure is also negatively associated with serum testosterone levels. > > > > > > > > > > > > > > > > - 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59 BS 125. D/C Spironolactone 12/20/2011 due to adverse SX. > > > > > > > > Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD and PTSD. > > > > > > > > Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate 10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11 to prepare for AVS. > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 3, 2012 Report Share Posted February 3, 2012 And how is the BP and K etc doing? Trust u are so DASHING to minimize need for Spiro. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Feb 3, 2012, at 0:55, Terri Bearhope <terribearhope@...> wrote: Hi Just to share my experience - I've been on spiro for about 4 months. Had terrible breast pain to start with (just like the pain I had at the very beginning of my first pregnancy)but it's now gone. I also had disrupted menstruation - that may have settled now but I probably need another 6 months to be sure. My 'slight hirsutism' (my consultant's words) has stayed the same. Terri (recently diagnosed with PA after about 10 years of unexplained high blood pressure which started when I was about 30) Quote Link to comment Share on other sites More sharing options...
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