Re: A Quick Comment/Question (Insomnia)

[Guest guest]

I hate to interrupt this conversation, it's been fun to watch, but I don't want

to loose some of the thoughts I had. I did some researching how Spironolactone

potentilly effects cortisol and posted some studies. I wondered if that might

be a factor with insomnia. I found this study which may have some basis. Have

a look:

Impact of Sleep and Its Disturbances on Hypothalamo-Pituitary-Adrenal Axis

Activity

Marcella Balbo, Leproult, and Eve Van Cauter*

Sleep, Chronobiology and Neuroendocrinology Research Laboratory, Department of

Medicine, The University of Chicago, Chicago, IL 60637, USA

*Eve Van Cauter: Email: evcauter@...

Academic Editor: Deborah Suchecki

Received December 11, 2009; Accepted March 27, 2010.

Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2902103/?tool=pubmed

" Abstract

The daily rhythm of cortisol secretion is relatively stable and primarily under

the influence of the circadian clock. Nevertheless, several other factors affect

hypothalamo-pituitary-adrenal (HPA) axis activity. Sleep has modest but clearly

detectable modulatory effects on HPA axis activity. Sleep onset exerts an

inhibitory effect on cortisol secretion while awakenings and sleep offset are

accompanied by cortisol stimulation. During waking, an association between

cortisol secretory bursts and indices of central arousal has also been detected.

Abrupt shifts of the sleep period induce a profound disruption in the daily

cortisol rhythm, while sleep deprivation and/or reduced sleep quality seem to

result in a modest but functionally important activation of the axis. HPA

hyperactivity is clearly associated with metabolic, cognitive and psychiatric

disorders and could be involved in the well-documented associations between

sleep disturbances and the risk of obesity, diabetes and cognitive dysfunction.

Several clinical syndromes, such as insomnia, depression, Cushing's syndrome,

sleep disordered breathing (SDB) display HPA hyperactivity, disturbed sleep,

psychiatric and metabolic impairments. Further research to delineate the

functional links between sleep and HPA axis activity is needed to fully

understand the pathophysiology of these syndromes and to develop adequate

strategies of prevention and treatment. "

One previous study talked about Spiro's limiting the gene for aldosterone

(CYP11B2) and altering its neighboring gene (CYP11B1). I have no conclusion

tonight but thought it interesting. Natalia, I don't know if you get the sme

effect with Epler.

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> > > Funny how after 5000 years a simple sentence of Buddha is distorted to

such extent…He simply said: “Investigate the truth independently.â€

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> > > No wonder it is said: truth is one word but ignorance multiplied it!...or

something like that J

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> > > Max.

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> > > Do you remember that:

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> > > Believe nothing just because a so-called wise person said it. Believe

nothing just because it is said to be of divine origin. Believe nothing just

because a belief is generally held. Believe nothing just because it is said in

ancient books. Believe nothing just because it is said to be of divine origin.

Believe nothing just because someone else believes it. Believe nothing just

because it is said to be of divine origin. Believe only what you, yourself,

test and judge to be true.

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> > > Buddha

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>