Agent Orange and Man Boobs

[Guest guest]

Does Agent Orange cause gyneocomastia? Maybe if you add a small dose of

Spironolactone!

Source: http://www.ncbi.nlm.nih.gov/pubmed/17107848

Serum dioxin, testosterone, and subsequent risk of benign prostatic hyperplasia:

a prospective cohort study of Air Force veterans.

Gupta A, Ketchum N, Roehrborn CG, Schecter A, Aragaki CC, Michalek JE.

Source

The University of Texas School of Public Health, Regional Campus at Dallas,

Dallas, Texas 75390-9110, USA. amit.gupta@...

Abstract

BACKGROUND:

Operation Ranch Hand veterans were involved in spraying herbicides, including

Agent Orange, during the Vietnam War in 1962-1971; Agent Orange was contaminated

with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). It has been hypothesized that

dioxins may be partially responsible for an increase of male reproductive tract

disorders such as testicular cancer, cryptorchidism, and hypospadias.

OBJECTIVES:

In this study, our objective was to assess the effect of serum TCDD

concentration on the risk of development of benign prostatic hyperplasia (BPH)

and on serum testosterone levels.

METHODS:

This study was a longitudinal, prospective cohort study made up of U.S. Air

Force veterans involved in Operation Ranch Hand. Other Air Force veterans who

did not spray herbicides were included as comparisons. BPH was determined by

medical record review and by medical examinations conducted during the study.

Data were available for 971 Ranch Hand and 1,266 comparison veterans. We

investigated the relationship between BPH and serum TCDD level using the

proportional hazards models adjusted for testosterone levels, body mass index

(BMI), and the percentage change in BMI per year.

RESULTS:

In univariate and multivariate analyses, the risk of BPH decreased with

increasing serum TCDD in the comparison group. The multivariate risk ratio for

BPH in the comparison group was 0.84 (95% confidence interval, 0.73-0.98).

Excluding men with prostate cancer, inflammatory or other prostatic diseases did

not substantially alter the association. Serum testosterone levels were

inversely associated with serum TCDD levels in both Ranch Hand and comparison

groups.

CONCLUSIONS:

TCDD exposure at general population levels is associated with a decreasing risk

of BPH with higher exposure levels. TCDD exposure is also negatively associated

with serum testosterone levels.

- 65 yo super ob., fastidious male - 12mm X 13mm rt. a.adnoma with

previous rt. flank pain. Treating with DASH. Stats w/o meds = BP 175/90 HR 59

BS 125. D/C Spironolactone 12/20/2011 due to adverse SX.

Other Issues/Opportunities: OSA w Bi-Pap settings 13/19, DM2, Gynecomastia, MDD

and PTSD.

Meds: Duloxetine hcl 80 MG, Metoprolol Tartrate 200 MG, AmlodipineBesylate

10mg, 81mg aspirin and Metformin 2000MG. Started washing Spironolactone 12/20/11

to prepare for AVS.