Re: Effects on Renin after surgery

[Guest guest]

Depends on aldo production, other meds, and salt intake.I would think it should be back to normal by 1 month and is almost always higher and aldo lower the day after surgery if the right one was taken out.CE Grim MDOn Apr 2, 2012, at 6:43 PM, Francis Bill SUSPECTED PA wrote: Do you know of any data that gives affects on Renin long term after surgery? Other then removal of adrenal gland would two weeks give enough to have renin return to pre surgey levels?

[Guest guest]

Guess I should have asked this a bit different. I had an appendectomy and two

weeks later had PRA test done. Becides the meds I was on for the PRA ratio test.

ATENOLOL25MG TRIAMTERENE50MG POTASSIUM CHLORIDE 20MEQ FUROSEMIDE 60MG TAB. Would

this change the outcome of the tests?

Evaluation for RENIN: 1.8 ng/mL/hr

Current Range:

Non-hypertensive adults:

RENIN: (upright/sitting) 0.65-5.0 ng/mL/hr

SERUM ALDOS: 16 ng/dL adult reference range:

Upright 8:00-10:00 am < or = 28 ng/dL

Upright 4:00-6:00 pm < or = 21 ng/dL

Supine 8:00-10:00 am 3-16 ng/dL

I am told the meds wouldn't effect test much by my now PCP.

>

> > Do you know of any data that gives affects on Renin long term after

> > surgery? Other then removal of adrenal gland would two weeks give

> > enough to have renin return to pre surgey levels?

> >

> >

>

[Guest guest]

The problem is I can not get the VA to retest me. And since they don't think I

have PA then no need to treat it.

> > >

> > > > Do you know of any data that gives affects on Renin long term after

> > > > surgery? Other then removal of adrenal gland would two weeks give

> > > > enough to have renin return to pre surgey levels?

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[Guest guest]

I am a long way from doing good. B/P and fluid may be better due to less salt

still have brain fog all the time. Also shortness of breath is a big problem.

I still need to work on DASH.

> > > > >

> > > > > > Do you know of any data that gives affects on Renin long

> > term after

> > > > > > surgery? Other then removal of adrenal gland would two weeks

> > give

> > > > > > enough to have renin return to pre surgey levels?

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[Guest guest]

I am thinking about doing this. Most likey would have to stop meds so would have

to have VA Dr that will do this. When I asked my PCP retesting because how the

Meds affect Aldo Renin tests was told he would not stop meds. He then lood at

test results that were done and told me meds didn't change meds enough to retest

off them.

> > > > > > >

> > > > > > > > Do you know of any data that gives affects on Renin long

> > > > term after

> > > > > > > > surgery? Other then removal of adrenal gland would two

> > weeks

> > > > give

> > > > > > > > enough to have renin return to pre surgey levels?

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[Guest guest]

I can give info on how to apply and he would have to have a doctor willing to

refer him and symptoms to justify the protocol he is applying for. " I think I

have PA would not work " First he/they would have to show SX, like BP, ARR and

other items that indicate he is a fit for what they are currently researching.

Asking about a 40 y/o cutoff is not what they are studying, that is a done deal.

Is is the result of many studies, done with controls and that is not a medical

decision, it is an actuarial decision IMHO. Insurance and government make the

final decision unless you can convince them otherwise or want to pay for it

yourself, IMHO!

> > > > > > >

> > > > > > > > Do you know of any data that gives affects on Renin long

> > > > term after

> > > > > > > > surgery? Other then removal of adrenal gland would two

> > weeks

> > > > give

> > > > > > > > enough to have renin return to pre surgey levels?

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[Guest guest]

What meds are you on that lower you renin? What is you renin? Are you using

your c-pap? What is your BP average for the last month ore more? (Are you

recording fasting BP numbers daily in MyheathEVet? Those are the things you

will need to even be considered IMHE (myhealtheved can be replaced by another

program that shows the results) Those are the kinds of things you will need or

it is a waste your's and my time to even consider it! Search the NIH website

and see what protocols are available to you, the one I am in is

00-CH-0160....JOHN.

> > > > > > > >

> > > > > > > > > Do you know of any data that gives affects on Renin long

> > > > > term after

> > > > > > > > > surgery? Other then removal of adrenal gland would two

> > > weeks

> > > > > give

> > > > > > > > > enough to have renin return to pre surgey levels?

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[Guest guest]

My suggestion, as per usual, is to RUN, do not pass go, to NIH! They continue

to be the best docs ever! And the nursing staff is second to none. The study

is now in the " sick " people phase. Sometime, they will close it and only allow

" healthy " (non symptomatic people) into the protocol. It won't be there

forever, in other words. All anyone needs to do is google NIH search the

studies...in the search box, put aldosterone, or hyperaldosteronism or the

protocol number that has on his signature....then, fill out the contact

info, send an email to Dr. Lyssikatos, he will call you and voila! You will then

have the very best evaluation, treatment and care for FREE! No ins., and as a

taxpayer, I am very happy to benefit from what I pay in taxes. I know it's not

FREE, nothing is, but I mean you pay your transportation and then benefit from

the government/tax supported National Institutes of Health research program.

You pay nothing out of pocket and they don't deal with your insurance even if

you have it. They even pay for your meds. It's a no brainer folks!

> > > > > > > >

> > > > > > > > > Do you know of any data that gives affects on Renin long

> > > > > term after

> > > > > > > > > surgery? Other then removal of adrenal gland would two

> > > weeks

> > > > > give

> > > > > > > > > enough to have renin return to pre surgey levels?

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[Guest guest]

Information from Endocrine Society PA Guidelines

Beta-adrenergic blockers atenolol being one may lower both renin and aldo

K+-wasting diuretics furosemide being one may or may not raise aldo but may

raise renin K+-sparing diuretics triamterene being one may raise both renin and

aldo. K status Hypokalemia may lower aldo and may or may not raise renin.

Potassium loading may raise aldo and may or may not lower aldo. Yes I use my

bi-pap not sure how much good it does. If they look at the many B/P readings

from the VA from my many visits to the ED and clinic then would find in high.

> > > > > > > > >

> > > > > > > > > > Do you know of any data that gives affects on Renin long

> > > > > > term after

> > > > > > > > > > surgery? Other then removal of adrenal gland would two

> > > > weeks

> > > > > > give

> > > > > > > > > > enough to have renin return to pre surgey levels?

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[Guest guest]

For this one only thing it says is you need the adrenal bump.

> > > > > > > > >

> > > > > > > > > > Do you know of any data that gives affects on Renin long

> > > > > > term after

> > > > > > > > > > surgery? Other then removal of adrenal gland would two

> > > > weeks

> > > > > > give

> > > > > > > > > > enough to have renin return to pre surgey levels?

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[Guest guest]

You have it right.

> > > > > > > > > > >

> > > > > > > > > > > > Do you know of any data that gives affects on

> > Renin long

> > > > > > > > term after

> > > > > > > > > > > > surgery? Other then removal of adrenal gland

> > would two

> > > > > > weeks

> > > > > > > > give

> > > > > > > > > > > > enough to have renin return to pre surgey levels?

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[Guest guest]

Depends on why you are taking them. Will not do much for B/P. Can help with

heart rate and may help with breathing problems. Some Data shows it can help

reduce stress.

> >> > > > > > > > > >

> >> > > > > > > > > > > Do you know of any data that gives affects on

> >> Renin long

> >> > > > > > > term after

> >> > > > > > > > > > > surgery? Other then removal of adrenal gland

> >> would two

> >> > > > > weeks

> >> > > > > > > give

> >> > > > > > > > > > > enough to have renin return to pre surgey levels?

> >> > > > > > > > > > >

> >> > > > > > > > > > >

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[Guest guest]

Beta blockers diminish the effects of epinephrine (adrenaline) and other stress

hormones.

I have found that if I stop taking atenolol my breathing gets worse. Not that it

is that good when taking it. Without it I almost can't function.

> > >> > > > > > > > > >

> > >> > > > > > > > > > > Do you know of any data that gives affects on

> > >> Renin long

> > >> > > > > > > term after

> > >> > > > > > > > > > > surgery? Other then removal of adrenal gland

> > >> would two

> > >> > > > > weeks

> > >> > > > > > > give

> > >> > > > > > > > > > > enough to have renin return to pre surgey levels?

> > >> > > > > > > > > > >

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[Guest guest]

you don't need an adrenal bump to be part of that protocol; I got in just on

badly done labwork, and a " normal " MRI. NIH docs did, however, read the MRI

themselves prior to my invitation, and saw abnormalities.

> > > > > > > > > >

> > > > > > > > > > > Do you know of any data that gives affects on Renin long

> > > > > > > term after

> > > > > > > > > > > surgery? Other then removal of adrenal gland would two

> > > > > weeks

> > > > > > > give

> > > > > > > > > > > enough to have renin return to pre surgey levels?

> > > > > > > > > > >

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[Guest guest]

All I have been told about the brain fog is they have no idea what is causing

it. I am told shortness of breath is due to deconditioning. after working with

PT for over a month was told they thought it was something other then

deconditioning But seems Dr don't believe PT.

> >

> > If your BP is at goal and you are feeling well then no reason to try

> > spiro I would think. You may have done well with DASH and current meds

> > and not need sprio or eplere.

> >

> > If either of these is a problem then a trial of spiro or eplerenone is

> > appropriate as both are approved for use in high blood pressure of

> > almost any kind.

>

>

> .

>

> <http://geo./serv?s=97359714/grpId=7299303/grpspId=1705132763/msgId

> =42099/stime=1333742700/nc1=5191951/nc2=3848643/nc3=5191945>

>

[Guest guest]

Francis, I was going to recommend a cardiologist, but then thought about NIH

again, and realized that if you go to NIH, they will also do a cardio workup on

you if you have cardiac issues. So, call NIH, Run, don't walk there....you

won't regret it.

> > >

> > > If your BP is at goal and you are feeling well then no reason to try

> > > spiro I would think. You may have done well with DASH and current meds

> > > and not need sprio or eplere.

> > >

> > > If either of these is a problem then a trial of spiro or eplerenone is

> > > appropriate as both are approved for use in high blood pressure of

> > > almost any kind.

> >

> >

> > .

> >

> > <http://geo./serv?s=97359714/grpId=7299303/grpspId=1705132763/msgId

> > =42099/stime=1333742700/nc1=5191951/nc2=3848643/nc3=5191945>

> >

>

[Guest guest]

Look for the right protocol first though because I will be extremely surprised

if this is it unless they are keeping a secret from me again!

> >> >

> >> > If your BP is at goal and you are feeling well then no reason to try

> >> > spiro I would think. You may have done well with DASH and current meds

> >> > and not need sprio or eplere.

> >> >

> >> > If either of these is a problem then a trial of spiro or eplerenone is

> >> > appropriate as both are approved for use in high blood pressure of

> >> > almost any kind.

> >

> >

> >.

> > Web Bug from

> >http://geo./serv?s=97359714/grpId=7299303/grpspId=1705132763/msgId=

> >42201/stime=1333976864/nc1=3848643/nc2=5191951/nc3=5191950

> ><http://www.mailscanner.tv/1x1spacer.gif>

> >

>

[Guest guest]

Study 1 of 1 for search of: 00-CH-0160

Study of Adrenal Gland Tumors

This study is currently recruiting participants.

Verified September 2011 by National Institutes of Health Clinical Center (CC)

First Received on June 28, 2000. Last Updated on March 20, 2012 History of

Changes

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human

Development (NICHD)

Information provided by: National Institutes of Health Clinical Center (CC)

ClinicalTrials.gov Identifier: NCT00005927

Criteria

•INCLUSION CRITERIA:

Patients are adults or children with evidence for the existence of a tumor of

the adrenal glands, as indicated by previously obtained imaging studies and/or

biochemical investigation of hormonal secretion. This condition is meant to

include the possibility of individuals with subclinical hormone secretion

syndromes, which may be detectable at the biochemical level even in the absence

of frank clinical signs/symptoms.

All eligible patients are invited to participate in this protocol, regardless of

sex, race or ethnic origin. All populations appear at risk for adrenal tumors,

and therefore the subject population can include Native Americans, Asian/Pacific

Islanders, Caucasian, Hispanic, and Black individuals. Patients will be accepted

for evaluation based on referral from clinicians, or may be self-referred, if

they can provide evidence supportive of the diagnosis of hormone oversecretion.

Patients must be willing to return to the NIH for follow-up evaluation.

> > >> >

> > >> > If your BP is at goal and you are feeling well then no reason to try

> > >> > spiro I would think. You may have done well with DASH and current meds

> > >> > and not need sprio or eplere.

> > >> >

> > >> > If either of these is a problem then a trial of spiro or eplerenone is

> > >> > appropriate as both are approved for use in high blood pressure of

> > >> > almost any kind.

> > >

> > >

> > >.

> > > Web Bug from

> >

>http://geo./serv?s=97359714/grpId=7299303/grpspId=1705132763/msgId=

> > >42201/stime=1333976864/nc1=3848643/nc2=5191951/nc3=5191950

> > ><http://www.mailscanner.tv/1x1spacer.gif>

> > >

> >

>

[Guest guest]

You are baiting me and even as punchy as I am I'm not falling. Look forward,

maybe just over the horizon and tell me what you see! IMHO they are not looking

for any old tumor, in fact my tumor was not what brought me here. It was

something else. With that said, I encourage you to check if you are so

inclined, It is certainly not my place to answer.

> > > > >> >

> > > > >> > If your BP is at goal and you are feeling well then no reason to

try

> > > > >> > spiro I would think. You may have done well with DASH and current

meds

> > > > >> > and not need sprio or eplere.

> > > > >> >

> > > > >> > If either of these is a problem then a trial of spiro or eplerenone

is

> > > > >> > appropriate as both are approved for use in high blood pressure of

> > > > >> > almost any kind.

> > > > >

> > > > >

> > > > >.

> > > > > Web Bug from

> > > >

>http://geo./serv?s=97359714/grpId=7299303/grpspId=1705132763/msgId=

> > > > >42201/stime=1333976864/nc1=3848643/nc2=5191951/nc3=5191950

> > > > ><http://www.mailscanner.tv/1x1spacer.gif>

> > > > >

> > > >

> > >

> >

> >

>

[Guest guest]

You can check this out by this link.

http://www.clinicaltrials.gov/ct2/show/NCT00005927?term=00-CH-0160 & rank=1

> > > > > >> >

> > > > > >> > If your BP is at goal and you are feeling well then no reason to

try

> > > > > >> > spiro I would think. You may have done well with DASH and current

meds

> > > > > >> > and not need sprio or eplere.

> > > > > >> >

> > > > > >> > If either of these is a problem then a trial of spiro or

eplerenone is

> > > > > >> > appropriate as both are approved for use in high blood pressure

of

> > > > > >> > almost any kind.

> > > > > >

> > > > > >

> > > > > >.

> > > > > > Web Bug from

> > > > >

>http://geo./serv?s=97359714/grpId=7299303/grpspId=1705132763/msgId=

> > > > > >42201/stime=1333976864/nc1=3848643/nc2=5191951/nc3=5191950

> > > > > ><http://www.mailscanner.tv/1x1spacer.gif>

> > > > > >

> > > > >

> > > >

> > >

> > >

> >

>

[Guest guest]

As far as I know never been tested for Babesiosis My SX don't seem to fit. While

I don't go every week have been many times due to SX.

> > >

> > > If your BP is at goal and you are feeling well then no reason to try

> > > spiro I would think. You may have done well with DASH and current meds

> > > and not need sprio or eplere.

> > >

> > > If either of these is a problem then a trial of spiro or eplerenone is

> > > appropriate as both are approved for use in high blood pressure of

> > > almost any kind.

>

>

> .

> Web Bug from

> http://geo./serv?s=97359714/grpId=7299303/grpspId=1705132763/msgId=

> 42201/stime=1333976864/nc1=3848643/nc2=5191951/nc3=5191950

> <http://www.mailscanner.tv/1x1spacer.gif>

>

[Guest guest]

I do believe Dr Grim has said he would contact my team. My last PCP didn't seem

to have any interest in this. Since my new one seem to thing nothing he is

seeing indicates PA then not likely to get very far with him. In fact other then

s Dr would be hard to find any other Dr at this VA that thinks PA is some

they will never see.

What is needed is to have someone like Dr Grim come to the VA and teach VA care

providers that PA is real and very common. I belive Dr Grim has tried to do this

but since he would like to be paid for his time as he should. He hasn't done it.

My thoughts are What ever Dr Grim would charge to do this would save the VA much

more then then they would pay him.

> >> >

> >> > If your BP is at goal and you are feeling well then no reason to try

> >> > spiro I would think. You may have done well with DASH and current meds

> >> > and not need sprio or eplere.

> >> >

> >> > If either of these is a problem then a trial of spiro or eplerenone is

> >> > appropriate as both are approved for use in high blood pressure of

> >> > almost any kind.

> >

> >

> >.

> > Web Bug from

> >http://geo./serv?s=97359714/grpId=7299303/grpspId=1705132763/msgId=

> >42201/stime=1333976864/nc1=3848643/nc2=5191951/nc3=5191950

> ><http://www.mailscanner.tv/1x1spacer.gif>

> >

>

[Guest guest]

The problem is DR has to be on board to some extent. I would have to stop meds.

Dr grim says this should only be done by Dr.

> > >> >

> > >> > If your BP is at goal and you are feeling well then no reason to try

> > >> > spiro I would think. You may have done well with DASH and current

> meds

> > >> > and not need sprio or eplere.

> > >> >

> > >> > If either of these is a problem then a trial of spiro or eplerenone

> is

> > >> > appropriate as both are approved for use in high blood pressure of

> > >> > almost any kind.

> > >

> > >

> > >.

> > > Web Bug from

> >

> >http://geo./serv?s=97359714/grpId=7299303/grpspId=1705132763/msgId

> =

> > >42201/stime=1333976864/nc1=3848643/nc2=5191951/nc3=5191950

> > ><http://www.mailscanner.tv/1x1spacer.gif>

> > >

> >

>

[Guest guest]

you can contact dr. lyssikatos. If you ask him, he can contact your

doc...contact him, discuss your situation with him, he will assess it, ask you

to send him some records which he will review and get back to you. It will be a

god send. He will answer all your questions and when you tell him you have

problematic drs., he will be all too familiar. Ask him to contact one of them,

and he will call, (as he did mine) and convince them to write the letter (as he

did mine). They will (as a team at NIH) look at your records and meds, etc. and

then, in tandem with your docs, manage your getting off your meds, etc. I have

heard that once NIH gets involved in a VA case, they hup to.

> > > > >> >

> > > > >> > If your BP is at goal and you are feeling well then no

> > reason to try

> > > > >> > spiro I would think. You may have done well with DASH and

> > current

> > > meds

> > > > >> > and not need sprio or eplere.

> > > > >> >

> > > > >> > If either of these is a problem then a trial of spiro or

> > eplerenone

> > > is

> > > > >> > appropriate as both are approved for use in high blood

> > pressure of

> > > > >> > almost any kind.

> > > > >

> > > > >

> > > > >.

> > > > > Web Bug from

> > > >

> > >

>http://geo./serv?s=97359714/grpId=7299303/grpspId=1705132763/msgId

> > > =

> > > > >42201/stime=1333976864/nc1=3848643/nc2=5191951/nc3=5191950

> > > > ><http://www.mailscanner.tv/1x1spacer.gif>

> > > > >

> > > >

> > >

> >

> >

>