Guest guest Posted April 16, 2012 Report Share Posted April 16, 2012 Was your ER visit due to results of NIH study? > > We meant yesterday afternoon when they " released " me. And I will share a little here but I actually know little more than you. > > The word Dr. M. used is " 17-Hydroxy-steroids. " 5 min. summary is here…. > > This is as far as I got before I literally ran out of gas last night! I woke up 4 hrs later, went to bed and now it is 5 am and I will finish that thought! > > From the patent info: 17-Hydroxy-steroids > Patent 4898694 Issued on February 6, 1990 > > > BACKGROUND OF THE INVENTION > > This invention relates to novel steroids and more particularly to androsterone derivatives useful as anti-cancer, anti-obesity, anti-diabetic, and hypolipidemic agents and useful for combatting coronary diseases. > > I'm early in understanding but it appears this or a mutation is suspected to be in my gene pool./ > > Okay, 3d try and I will send this today whether or not I get it finished! I don't know much more since I spent last night in the ER. > > I knew early that they were investigating hyperaldosteronism as a " masking " condition and were more concerned about what was hiding behind it. They were quite surprised when I used the term CYP11B1 because this is apparently a close relative of Cortisol. That is likely why Spironolactone is not right in this condition. When there is already an excess cort issue and the action of spiro increases it more it becomes a " DOUBLE WHAMMY " ! Sorry for the technical jargon, I'll work on the complete answer, maybe! > > I'll send this now before I get distracted again. I still need to figure out where this trip is headed but am honored to have a front row seat! We'll need to decide how much you want to know. > > .... > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2012 Report Share Posted April 16, 2012 Yes, I guess. I was on such an emotional high and I knew I was going to crash. I felt 50 miles may be too far to travel if that happened and 24/7 call nurse agreed and suggested I visit ER. Had a good chat with a young doctor and he put me up in " the Lodge " for the night and I suggested he go home and have a quite evening! > > > > We meant yesterday afternoon when they " released " me. And I will share a little here but I actually know little more than you. > > > > The word Dr. M. used is " 17-Hydroxy-steroids. " 5 min. summary is here…. > > > > This is as far as I got before I literally ran out of gas last night! I woke up 4 hrs later, went to bed and now it is 5 am and I will finish that thought! > > > > From the patent info: 17-Hydroxy-steroids > > Patent 4898694 Issued on February 6, 1990 > > > > > > BACKGROUND OF THE INVENTION > > > > This invention relates to novel steroids and more particularly to androsterone derivatives useful as anti-cancer, anti-obesity, anti-diabetic, and hypolipidemic agents and useful for combatting coronary diseases. > > > > I'm early in understanding but it appears this or a mutation is suspected to be in my gene pool./ > > > > Okay, 3d try and I will send this today whether or not I get it finished! I don't know much more since I spent last night in the ER. > > > > I knew early that they were investigating hyperaldosteronism as a " masking " condition and were more concerned about what was hiding behind it. They were quite surprised when I used the term CYP11B1 because this is apparently a close relative of Cortisol. That is likely why Spironolactone is not right in this condition. When there is already an excess cort issue and the action of spiro increases it more it becomes a " DOUBLE WHAMMY " ! Sorry for the technical jargon, I'll work on the complete answer, maybe! > > > > I'll send this now before I get distracted again. I still need to figure out where this trip is headed but am honored to have a front row seat! We'll need to decide how much you want to know. > > > > .... > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 16, 2012 Report Share Posted April 16, 2012 Maybe there are references that can be sent or we can look up?CE Grim MDOn Apr 16, 2012, at 2:24 PM, wrote: We meant yesterday afternoon when they "released" me. And I will share a little here but I actually know little more than you. The word Dr. M. used is " 17-Hydroxy-steroids." 5 min. summary is here…. This is as far as I got before I literally ran out of gas last night! I woke up 4 hrs later, went to bed and now it is 5 am and I will finish that thought! From the patent info: 17-Hydroxy-steroids Patent 4898694 Issued on February 6, 1990 BACKGROUND OF THE INVENTION This invention relates to novel steroids and more particularly to androsterone derivatives useful as anti-cancer, anti-obesity, anti-diabetic, and hypolipidemic agents and useful for combatting coronary diseases. I'm early in understanding but it appears this or a mutation is suspected to be in my gene pool./ Okay, 3d try and I will send this today whether or not I get it finished! I don't know much more since I spent last night in the ER. I knew early that they were investigating hyperaldosteronism as a "masking" condition and were more concerned about what was hiding behind it. They were quite surprised when I used the term CYP11B1 because this is apparently a close relative of Cortisol. That is likely why Spironolactone is not right in this condition. When there is already an excess cort issue and the action of spiro increases it more it becomes a "DOUBLE WHAMMY"! Sorry for the technical jargon, I'll work on the complete answer, maybe! I'll send this now before I get distracted again. I still need to figure out where this trip is headed but am honored to have a front row seat! We'll need to decide how much you want to know. .... Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2012 Report Share Posted April 17, 2012 This would be very common in Bipolar Disorder. Saw this many times in my mother. Might want to research this. > > > > > > We meant yesterday afternoon when they " released " me. And I will share a little here but I actually know little more than you. > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids. " 5 min. summary is here…. > > > > > > This is as far as I got before I literally ran out of gas last night! I woke up 4 hrs later, went to bed and now it is 5 am and I will finish that thought! > > > > > > From the patent info: 17-Hydroxy-steroids > > > Patent 4898694 Issued on February 6, 1990 > > > > > > > > > BACKGROUND OF THE INVENTION > > > > > > This invention relates to novel steroids and more particularly to androsterone derivatives useful as anti-cancer, anti-obesity, anti-diabetic, and hypolipidemic agents and useful for combatting coronary diseases. > > > > > > I'm early in understanding but it appears this or a mutation is suspected to be in my gene pool./ > > > > > > Okay, 3d try and I will send this today whether or not I get it finished! I don't know much more since I spent last night in the ER. > > > > > > I knew early that they were investigating hyperaldosteronism as a " masking " condition and were more concerned about what was hiding behind it. They were quite surprised when I used the term CYP11B1 because this is apparently a close relative of Cortisol. That is likely why Spironolactone is not right in this condition. When there is already an excess cort issue and the action of spiro increases it more it becomes a " DOUBLE WHAMMY " ! Sorry for the technical jargon, I'll work on the complete answer, maybe! > > > > > > I'll send this now before I get distracted again. I still need to figure out where this trip is headed but am honored to have a front row seat! We'll need to decide how much you want to know. > > > > > > .... > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2012 Report Share Posted April 17, 2012 I will be happy to share facts and references if/as I find them. I haven't started looking because I expect a summary once all the tests are back. They are certainly talking at a much lower level than I am able to. If anyone is interested in getting an idea as to what they are working on I suggest a Pubmed search on author: Stratakis, Constantine A. and check out the 340 hits. If you tire of that you might take a quick look at CUSHING'S Syndrome. Before you mention it Dr. Grim, I understand the " moon face " is not a requirement, at least in this " masked " situation. Nurse Jill provided me a couple of papers from the Mayo Clinic and allI can say is I thought all those SXs were associated with low K which I didn't have! Before everyone develops this masked syndrome let Dr. Stratakis, his team and I see if we can reduce the testing to a little less than a quarter mil dollars! It's classified as " very rare " at the moment! (Hint, every time I turn around I hear something called DNA. Makes you wonder if they are looking to reduce the playing field with a swab doesn't it.) I have learned a lot about the value of proper testing by competent professionals! I believe every test I had was a standard test with particular attention paid to preparation, ie off Metformin prior to contrast. Medicine and treatment is constantly changing and yesterday's treatment may be yesterday's news! Living without adrenals may not be the most desirable but may be better than " living " with BAD adrenals! I had 3 different nurses explain that and their observation from treating PTNs, they gain more experience every day! It's off the table now but I'm not afraid of it! ..... > > > We meant yesterday afternoon when they " released " me. And I will > > share a little here but I actually know little more than you. > > > > The word Dr. M. used is " 17-Hydroxy-steroids. " 5 min. summary is > > here…. > > > > This is as far as I got before I literally ran out of gas last > > night! I woke up 4 hrs later, went to bed and now it is 5 am and I > > will finish that thought! > > > > From the patent info: 17-Hydroxy-steroids > > Patent 4898694 Issued on February 6, 1990 > > > > BACKGROUND OF THE INVENTION > > > > This invention relates to novel steroids and more particularly to > > androsterone derivatives useful as anti-cancer, anti-obesity, anti- > > diabetic, and hypolipidemic agents and useful for combatting > > coronary diseases. > > > > I'm early in understanding but it appears this or a mutation is > > suspected to be in my gene pool./ > > > > Okay, 3d try and I will send this today whether or not I get it > > finished! I don't know much more since I spent last night in the ER. > > > > I knew early that they were investigating hyperaldosteronism as a > > " masking " condition and were more concerned about what was hiding > > behind it. They were quite surprised when I used the term CYP11B1 > > because this is apparently a close relative of Cortisol. That is > > likely why Spironolactone is not right in this condition. When there > > is already an excess cort issue and the action of spiro increases it > > more it becomes a " DOUBLE WHAMMY " ! Sorry for the technical jargon, > > I'll work on the complete answer, maybe! > > > > I'll send this now before I get distracted again. I still need to > > figure out where this trip is headed but am honored to have a front > > row seat! We'll need to decide how much you want to know. > > > > .... > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2012 Report Share Posted April 17, 2012 It may not be that rare. In fact can find many that have both SX of PA and cushing's. > > > > > We meant yesterday afternoon when they " released " me. And I will > > > share a little here but I actually know little more than you. > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids. " 5 min. summary is > > > here…. > > > > > > This is as far as I got before I literally ran out of gas last > > > night! I woke up 4 hrs later, went to bed and now it is 5 am and I > > > will finish that thought! > > > > > > From the patent info: 17-Hydroxy-steroids > > > Patent 4898694 Issued on February 6, 1990 > > > > > > BACKGROUND OF THE INVENTION > > > > > > This invention relates to novel steroids and more particularly to > > > androsterone derivatives useful as anti-cancer, anti-obesity, anti- > > > diabetic, and hypolipidemic agents and useful for combatting > > > coronary diseases. > > > > > > I'm early in understanding but it appears this or a mutation is > > > suspected to be in my gene pool./ > > > > > > Okay, 3d try and I will send this today whether or not I get it > > > finished! I don't know much more since I spent last night in the ER. > > > > > > I knew early that they were investigating hyperaldosteronism as a > > > " masking " condition and were more concerned about what was hiding > > > behind it. They were quite surprised when I used the term CYP11B1 > > > because this is apparently a close relative of Cortisol. That is > > > likely why Spironolactone is not right in this condition. When there > > > is already an excess cort issue and the action of spiro increases it > > > more it becomes a " DOUBLE WHAMMY " ! Sorry for the technical jargon, > > > I'll work on the complete answer, maybe! > > > > > > I'll send this now before I get distracted again. I still need to > > > figure out where this trip is headed but am honored to have a front > > > row seat! We'll need to decide how much you want to know. > > > > > > .... > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2012 Report Share Posted April 17, 2012 Cushing's evolves much like PA but have not written about that as much. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Apr 17, 2012, at 8:39, <jclark24p@...> wrote: I will be happy to share facts and references if/as I find them. I haven't started looking because I expect a summary once all the tests are back. They are certainly talking at a much lower level than I am able to. If anyone is interested in getting an idea as to what they are working on I suggest a Pubmed search on author: Stratakis, Constantine A. and check out the 340 hits. If you tire of that you might take a quick look at CUSHING'S Syndrome. Before you mention it Dr. Grim, I understand the "moon face" is not a requirement, at least in this "masked" situation. Nurse Jill provided me a couple of papers from the Mayo Clinic and allI can say is I thought all those SXs were associated with low K which I didn't have! Before everyone develops this masked syndrome let Dr. Stratakis, his team and I see if we can reduce the testing to a little less than a quarter mil dollars! It's classified as "very rare" at the moment! (Hint, every time I turn around I hear something called DNA. Makes you wonder if they are looking to reduce the playing field with a swab doesn't it.) I have learned a lot about the value of proper testing by competent professionals! I believe every test I had was a standard test with particular attention paid to preparation, ie off Metformin prior to contrast. Medicine and treatment is constantly changing and yesterday's treatment may be yesterday's news! Living without adrenals may not be the most desirable but may be better than "living" with BAD adrenals! I had 3 different nurses explain that and their observation from treating PTNs, they gain more experience every day! It's off the table now but I'm not afraid of it! ..... > > > We meant yesterday afternoon when they "released" me. And I will > > share a little here but I actually know little more than you. > > > > The word Dr. M. used is " 17-Hydroxy-steroids." 5 min. summary is > > here…. > > > > This is as far as I got before I literally ran out of gas last > > night! I woke up 4 hrs later, went to bed and now it is 5 am and I > > will finish that thought! > > > > From the patent info: 17-Hydroxy-steroids > > Patent 4898694 Issued on February 6, 1990 > > > > BACKGROUND OF THE INVENTION > > > > This invention relates to novel steroids and more particularly to > > androsterone derivatives useful as anti-cancer, anti-obesity, anti- > > diabetic, and hypolipidemic agents and useful for combatting > > coronary diseases. > > > > I'm early in understanding but it appears this or a mutation is > > suspected to be in my gene pool./ > > > > Okay, 3d try and I will send this today whether or not I get it > > finished! I don't know much more since I spent last night in the ER. > > > > I knew early that they were investigating hyperaldosteronism as a > > "masking" condition and were more concerned about what was hiding > > behind it. They were quite surprised when I used the term CYP11B1 > > because this is apparently a close relative of Cortisol. That is > > likely why Spironolactone is not right in this condition. When there > > is already an excess cort issue and the action of spiro increases it > > more it becomes a "DOUBLE WHAMMY"! Sorry for the technical jargon, > > I'll work on the complete answer, maybe! > > > > I'll send this now before I get distracted again. I still need to > > figure out where this trip is headed but am honored to have a front > > row seat! We'll need to decide how much you want to know. > > > > .... > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2012 Report Share Posted April 17, 2012 Sx of both are common in other problems as well. So need to do proper testing when suspected. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Apr 17, 2012, at 8:58, Francis Bill SUSPECTED PA <georgewbill@...> wrote: It may not be that rare. In fact can find many that have both SX of PA and cushing's. > > > > > We meant yesterday afternoon when they "released" me. And I will > > > share a little here but I actually know little more than you. > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids." 5 min. summary is > > > here…. > > > > > > This is as far as I got before I literally ran out of gas last > > > night! I woke up 4 hrs later, went to bed and now it is 5 am and I > > > will finish that thought! > > > > > > From the patent info: 17-Hydroxy-steroids > > > Patent 4898694 Issued on February 6, 1990 > > > > > > BACKGROUND OF THE INVENTION > > > > > > This invention relates to novel steroids and more particularly to > > > androsterone derivatives useful as anti-cancer, anti-obesity, anti- > > > diabetic, and hypolipidemic agents and useful for combatting > > > coronary diseases. > > > > > > I'm early in understanding but it appears this or a mutation is > > > suspected to be in my gene pool./ > > > > > > Okay, 3d try and I will send this today whether or not I get it > > > finished! I don't know much more since I spent last night in the ER. > > > > > > I knew early that they were investigating hyperaldosteronism as a > > > "masking" condition and were more concerned about what was hiding > > > behind it. They were quite surprised when I used the term CYP11B1 > > > because this is apparently a close relative of Cortisol. That is > > > likely why Spironolactone is not right in this condition. When there > > > is already an excess cort issue and the action of spiro increases it > > > more it becomes a "DOUBLE WHAMMY"! Sorry for the technical jargon, > > > I'll work on the complete answer, maybe! > > > > > > I'll send this now before I get distracted again. I still need to > > > figure out where this trip is headed but am honored to have a front > > > row seat! We'll need to decide how much you want to know. > > > > > > .... > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2012 Report Share Posted April 17, 2012 Sx of both are common in other problems as well. So need to do proper testing when suspected. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Apr 17, 2012, at 8:58, Francis Bill SUSPECTED PA <georgewbill@...> wrote: It may not be that rare. In fact can find many that have both SX of PA and cushing's. > > > > > We meant yesterday afternoon when they "released" me. And I will > > > share a little here but I actually know little more than you. > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids." 5 min. summary is > > > here…. > > > > > > This is as far as I got before I literally ran out of gas last > > > night! I woke up 4 hrs later, went to bed and now it is 5 am and I > > > will finish that thought! > > > > > > From the patent info: 17-Hydroxy-steroids > > > Patent 4898694 Issued on February 6, 1990 > > > > > > BACKGROUND OF THE INVENTION > > > > > > This invention relates to novel steroids and more particularly to > > > androsterone derivatives useful as anti-cancer, anti-obesity, anti- > > > diabetic, and hypolipidemic agents and useful for combatting > > > coronary diseases. > > > > > > I'm early in understanding but it appears this or a mutation is > > > suspected to be in my gene pool./ > > > > > > Okay, 3d try and I will send this today whether or not I get it > > > finished! I don't know much more since I spent last night in the ER. > > > > > > I knew early that they were investigating hyperaldosteronism as a > > > "masking" condition and were more concerned about what was hiding > > > behind it. They were quite surprised when I used the term CYP11B1 > > > because this is apparently a close relative of Cortisol. That is > > > likely why Spironolactone is not right in this condition. When there > > > is already an excess cort issue and the action of spiro increases it > > > more it becomes a "DOUBLE WHAMMY"! Sorry for the technical jargon, > > > I'll work on the complete answer, maybe! > > > > > > I'll send this now before I get distracted again. I still need to > > > figure out where this trip is headed but am honored to have a front > > > row seat! We'll need to decide how much you want to know. > > > > > > .... > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 17, 2012 Report Share Posted April 17, 2012 Have no reason to deny or agree with your assessment however I would leave the concluslusions re 17 hydroxy to the ones who received the patient 22 years ago and are working through the process! The next step is to find a family willing to be a controlled focus group. (There may very well be more than one) I will be working on a pedigree for one in the next few days. BTW if you have both I would suggest you pay attention to cushing because as I understand it, the treatment for reducing excess cortisol is very limited! > > > > > > > We meant yesterday afternoon when they " released " me. And I will > > > > share a little here but I actually know little more than you. > > > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids. " 5 min. summary is > > > > here…. > > > > > > > > This is as far as I got before I literally ran out of gas last > > > > night! I woke up 4 hrs later, went to bed and now it is 5 am and I > > > > will finish that thought! > > > > > > > > From the patent info: 17-Hydroxy-steroids > > > > Patent 4898694 Issued on February 6, 1990 > > > > > > > > BACKGROUND OF THE INVENTION > > > > > > > > This invention relates to novel steroids and more particularly to > > > > androsterone derivatives useful as anti-cancer, anti-obesity, anti- > > > > diabetic, and hypolipidemic agents and useful for combatting > > > > coronary diseases. > > > > > > > > I'm early in understanding but it appears this or a mutation is > > > > suspected to be in my gene pool./ > > > > > > > > Okay, 3d try and I will send this today whether or not I get it > > > > finished! I don't know much more since I spent last night in the ER. > > > > > > > > I knew early that they were investigating hyperaldosteronism as a > > > > " masking " condition and were more concerned about what was hiding > > > > behind it. They were quite surprised when I used the term CYP11B1 > > > > because this is apparently a close relative of Cortisol. That is > > > > likely why Spironolactone is not right in this condition. When there > > > > is already an excess cort issue and the action of spiro increases it > > > > more it becomes a " DOUBLE WHAMMY " ! Sorry for the technical jargon, > > > > I'll work on the complete answer, maybe! > > > > > > > > I'll send this now before I get distracted again. I still need to > > > > figure out where this trip is headed but am honored to have a front > > > > row seat! We'll need to decide how much you want to know. > > > > > > > > .... > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2012 Report Share Posted April 21, 2012 Dr. Grim, I went back to this one because it made me so happy to hear you advocate proper testing. My case is considered real rare and as I understand it can be even more challenging when you have one condition " masking " another condition and throw in a muted gene just to keep Endroconologists employed! The more I look, the more I understand why Dr. Moriatis gave me 45 minutes at close eye contact, no phone ringing, back to clock and he never looked over his sholder! (At least 4 nurses asked me how I kept his undivided attention for so long!) If I am right this is a very hot subject in atleast 3 countries and NIH may have just found their " Lab Rat " so they can play too! A pubmed article last week may have summarized it as well as anyone, " These findings have sparked considerable interest, and over the next 12 months a number of additional reports can be confidently expected to throw light on both normal and abnormal adrenocortical zonation and the genesis of primary aldosteronism. " I'm not quite ready to share my speculations but will be asking Dr. Moriatis a direct question this weekend and he has promised to never lie to me! > > > > > > > > > We meant yesterday afternoon when they " released " me. And I will > > > > > share a little here but I actually know little more than you. > > > > > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids. " 5 min. summary is > > > > > here…. > > > > > > > > > > This is as far as I got before I literally ran out of gas last > > > > > night! I woke up 4 hrs later, went to bed and now it is 5 am and I > > > > > will finish that thought! > > > > > > > > > > From the patent info: 17-Hydroxy-steroids > > > > > Patent 4898694 Issued on February 6, 1990 > > > > > > > > > > BACKGROUND OF THE INVENTION > > > > > > > > > > This invention relates to novel steroids and more particularly to > > > > > androsterone derivatives useful as anti-cancer, anti-obesity, anti- > > > > > diabetic, and hypolipidemic agents and useful for combatting > > > > > coronary diseases. > > > > > > > > > > I'm early in understanding but it appears this or a mutation is > > > > > suspected to be in my gene pool./ > > > > > > > > > > Okay, 3d try and I will send this today whether or not I get it > > > > > finished! I don't know much more since I spent last night in the ER. > > > > > > > > > > I knew early that they were investigating hyperaldosteronism as a > > > > > " masking " condition and were more concerned about what was hiding > > > > > behind it. They were quite surprised when I used the term CYP11B1 > > > > > because this is apparently a close relative of Cortisol. That is > > > > > likely why Spironolactone is not right in this condition. When there > > > > > is already an excess cort issue and the action of spiro increases it > > > > > more it becomes a " DOUBLE WHAMMY " ! Sorry for the technical jargon, > > > > > I'll work on the complete answer, maybe! > > > > > > > > > > I'll send this now before I get distracted again. I still need to > > > > > figure out where this trip is headed but am honored to have a front > > > > > row seat! We'll need to decide how much you want to know. > > > > > > > > > > .... > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2012 Report Share Posted April 21, 2012 You are not a lab rat. Rats cannot say no. I have always said that man is the ultimate experimental animal that I will (have) spend my life working on. I have never treated a rat or a mouse. And you can always say no to any research proposed.CE Grim MD On Apr 21, 2012, at 10:01 AM, wrote: Dr. Grim, I went back to this one because it made me so happy to hear you advocate proper testing. My case is considered real rare and as I understand it can be even more challenging when you have one condition "masking" another condition and throw in a muted gene just to keep Endroconologists employed! The more I look, the more I understand why Dr. Moriatis gave me 45 minutes at close eye contact, no phone ringing, back to clock and he never looked over his sholder! (At least 4 nurses asked me how I kept his undivided attention for so long!) If I am right this is a very hot subject in atleast 3 countries and NIH may have just found their "Lab Rat" so they can play too! A pubmed article last week may have summarized it as well as anyone, "These findings have sparked considerable interest, and over the next 12 months a number of additional reports can be confidently expected to throw light on both normal and abnormal adrenocortical zonation and the genesis of primary aldosteronism." I'm not quite ready to share my speculations but will be asking Dr. Moriatis a direct question this weekend and he has promised to never lie to me! > > > > > > > > > We meant yesterday afternoon when they "released" me. And I will > > > > > share a little here but I actually know little more than you. > > > > > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids." 5 min. summary is > > > > > here…. > > > > > > > > > > This is as far as I got before I literally ran out of gas last > > > > > night! I woke up 4 hrs later, went to bed and now it is 5 am and I > > > > > will finish that thought! > > > > > > > > > > From the patent info: 17-Hydroxy-steroids > > > > > Patent 4898694 Issued on February 6, 1990 > > > > > > > > > > BACKGROUND OF THE INVENTION > > > > > > > > > > This invention relates to novel steroids and more particularly to > > > > > androsterone derivatives useful as anti-cancer, anti-obesity, anti- > > > > > diabetic, and hypolipidemic agents and useful for combatting > > > > > coronary diseases. > > > > > > > > > > I'm early in understanding but it appears this or a mutation is > > > > > suspected to be in my gene pool./ > > > > > > > > > > Okay, 3d try and I will send this today whether or not I get it > > > > > finished! I don't know much more since I spent last night in the ER. > > > > > > > > > > I knew early that they were investigating hyperaldosteronism as a > > > > > "masking" condition and were more concerned about what was hiding > > > > > behind it. They were quite surprised when I used the term CYP11B1 > > > > > because this is apparently a close relative of Cortisol. That is > > > > > likely why Spironolactone is not right in this condition. When there > > > > > is already an excess cort issue and the action of spiro increases it > > > > > more it becomes a "DOUBLE WHAMMY"! Sorry for the technical jargon, > > > > > I'll work on the complete answer, maybe! > > > > > > > > > > I'll send this now before I get distracted again. I still need to > > > > > figure out where this trip is headed but am honored to have a front > > > > > row seat! We'll need to decide how much you want to know. > > > > > > > > > > .... > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2012 Report Share Posted April 21, 2012 Did you know that they are starting to use lawyers as test subjects for medical research - they found that there were some things that a lab rat just wouldn't do. Sorry, I couldn't resist - Dr. Grim's comment brought to mind an old joke told by a young lawyer! > > > > > > > > > > > > > We meant yesterday afternoon when they " released " me. And > > I will > > > > > > > share a little here but I actually know little more than > > you. > > > > > > > > > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids. " 5 min. > > summary is > > > > > > > here…. > > > > > > > > > > > > > > This is as far as I got before I literally ran out of gas > > last > > > > > > > night! I woke up 4 hrs later, went to bed and now it is 5 > > am and I > > > > > > > will finish that thought! > > > > > > > > > > > > > > From the patent info: 17-Hydroxy-steroids > > > > > > > Patent 4898694 Issued on February 6, 1990 > > > > > > > > > > > > > > BACKGROUND OF THE INVENTION > > > > > > > > > > > > > > This invention relates to novel steroids and more > > particularly to > > > > > > > androsterone derivatives useful as anti-cancer, anti- > > obesity, anti- > > > > > > > diabetic, and hypolipidemic agents and useful for combatting > > > > > > > coronary diseases. > > > > > > > > > > > > > > I'm early in understanding but it appears this or a > > mutation is > > > > > > > suspected to be in my gene pool./ > > > > > > > > > > > > > > Okay, 3d try and I will send this today whether or not I > > get it > > > > > > > finished! I don't know much more since I spent last night > > in the ER. > > > > > > > > > > > > > > I knew early that they were investigating > > hyperaldosteronism as a > > > > > > > " masking " condition and were more concerned about what was > > hiding > > > > > > > behind it. They were quite surprised when I used the term > > CYP11B1 > > > > > > > because this is apparently a close relative of Cortisol. > > That is > > > > > > > likely why Spironolactone is not right in this condition. > > When there > > > > > > > is already an excess cort issue and the action of spiro > > increases it > > > > > > > more it becomes a " DOUBLE WHAMMY " ! Sorry for the technical > > jargon, > > > > > > > I'll work on the complete answer, maybe! > > > > > > > > > > > > > > I'll send this now before I get distracted again. I still > > need to > > > > > > > figure out where this trip is headed but am honored to > > have a front > > > > > > > row seat! We'll need to decide how much you want to know. > > > > > > > > > > > > > > .... > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2012 Report Share Posted April 21, 2012 You didn't see my " tongue in cheek " ! This is always made very clear and you sign many releases. It's also good to keep focus and young doctors in line. I'm considering a 1-pager " How to be a good lab rat " for them. Hint1: " Feeling like a Rat? Raise the blind instead of opening it. You won't feel like you are looking theough the bars! " > > > > > > > > > > > > > We meant yesterday afternoon when they " released " me. And > > I will > > > > > > > share a little here but I actually know little more than > > you. > > > > > > > > > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids. " 5 min. > > summary is > > > > > > > here…. > > > > > > > > > > > > > > This is as far as I got before I literally ran out of gas > > last > > > > > > > night! I woke up 4 hrs later, went to bed and now it is 5 > > am and I > > > > > > > will finish that thought! > > > > > > > > > > > > > > From the patent info: 17-Hydroxy-steroids > > > > > > > Patent 4898694 Issued on February 6, 1990 > > > > > > > > > > > > > > BACKGROUND OF THE INVENTION > > > > > > > > > > > > > > This invention relates to novel steroids and more > > particularly to > > > > > > > androsterone derivatives useful as anti-cancer, anti- > > obesity, anti- > > > > > > > diabetic, and hypolipidemic agents and useful for combatting > > > > > > > coronary diseases. > > > > > > > > > > > > > > I'm early in understanding but it appears this or a > > mutation is > > > > > > > suspected to be in my gene pool./ > > > > > > > > > > > > > > Okay, 3d try and I will send this today whether or not I > > get it > > > > > > > finished! I don't know much more since I spent last night > > in the ER. > > > > > > > > > > > > > > I knew early that they were investigating > > hyperaldosteronism as a > > > > > > > " masking " condition and were more concerned about what was > > hiding > > > > > > > behind it. They were quite surprised when I used the term > > CYP11B1 > > > > > > > because this is apparently a close relative of Cortisol. > > That is > > > > > > > likely why Spironolactone is not right in this condition. > > When there > > > > > > > is already an excess cort issue and the action of spiro > > increases it > > > > > > > more it becomes a " DOUBLE WHAMMY " ! Sorry for the technical > > jargon, > > > > > > > I'll work on the complete answer, maybe! > > > > > > > > > > > > > > I'll send this now before I get distracted again. I still > > need to > > > > > > > figure out where this trip is headed but am honored to > > have a front > > > > > > > row seat! We'll need to decide how much you want to know. > > > > > > > > > > > > > > .... > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2012 Report Share Posted April 21, 2012 You didn't see my " tongue in cheek " ! This is always made very clear and you sign many releases. It's also good to keep focus and young doctors in line. I'm considering a 1-pager " How to be a good lab rat " for them. Hint1: " Feeling like a Rat? Raise the blind instead of opening it. You won't feel like you are looking theough the bars! " > > > > > > > > > > > > > We meant yesterday afternoon when they " released " me. And > > I will > > > > > > > share a little here but I actually know little more than > > you. > > > > > > > > > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids. " 5 min. > > summary is > > > > > > > here…. > > > > > > > > > > > > > > This is as far as I got before I literally ran out of gas > > last > > > > > > > night! I woke up 4 hrs later, went to bed and now it is 5 > > am and I > > > > > > > will finish that thought! > > > > > > > > > > > > > > From the patent info: 17-Hydroxy-steroids > > > > > > > Patent 4898694 Issued on February 6, 1990 > > > > > > > > > > > > > > BACKGROUND OF THE INVENTION > > > > > > > > > > > > > > This invention relates to novel steroids and more > > particularly to > > > > > > > androsterone derivatives useful as anti-cancer, anti- > > obesity, anti- > > > > > > > diabetic, and hypolipidemic agents and useful for combatting > > > > > > > coronary diseases. > > > > > > > > > > > > > > I'm early in understanding but it appears this or a > > mutation is > > > > > > > suspected to be in my gene pool./ > > > > > > > > > > > > > > Okay, 3d try and I will send this today whether or not I > > get it > > > > > > > finished! I don't know much more since I spent last night > > in the ER. > > > > > > > > > > > > > > I knew early that they were investigating > > hyperaldosteronism as a > > > > > > > " masking " condition and were more concerned about what was > > hiding > > > > > > > behind it. They were quite surprised when I used the term > > CYP11B1 > > > > > > > because this is apparently a close relative of Cortisol. > > That is > > > > > > > likely why Spironolactone is not right in this condition. > > When there > > > > > > > is already an excess cort issue and the action of spiro > > increases it > > > > > > > more it becomes a " DOUBLE WHAMMY " ! Sorry for the technical > > jargon, > > > > > > > I'll work on the complete answer, maybe! > > > > > > > > > > > > > > I'll send this now before I get distracted again. I still > > need to > > > > > > > figure out where this trip is headed but am honored to > > have a front > > > > > > > row seat! We'll need to decide how much you want to know. > > > > > > > > > > > > > > .... > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2012 Report Share Posted April 21, 2012 > > > > > > >> > > > > > > > We meant yesterday afternoon when they "released" me. And > > > I will> > > > > > > > share a little here but I actually know little more than > > > you.> > > > > > > >> > > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids." 5 min. > > > summary is> > > > > > > > here….> > > > > > > >> > > > > > > > This is as far as I got before I literally ran out of gas > > > last> > > > > > > > night! I woke up 4 hrs later, went to bed and now it is 5 > > > am and I> > > > > > > > will finish that thought!> > > > > > > >> > > > > > > > From the patent info: 17-Hydroxy-steroids> > > > > > > > Patent 4898694 Issued on February 6, 1990> > > > > > > >> > > > > > > > BACKGROUND OF THE INVENTION> > > > > > > >> > > > > > > > This invention relates to novel steroids and more > > > particularly to> > > > > > > > androsterone derivatives useful as anti-cancer, anti- > > > obesity, anti-> > > > > > > > diabetic, and hypolipidemic agents and useful for combatting> > > > > > > > coronary diseases.> > > > > > > >> > > > > > > > I'm early in understanding but it appears this or a > > > mutation is> > > > > > > > suspected to be in my gene pool./> > > > > > > >> > > > > > > > Okay, 3d try and I will send this today whether or not I > > > get it> > > > > > > > finished! I don't know much more since I spent last night > > > in the ER.> > > > > > > >> > > > > > > > I knew early that they were investigating > > > hyperaldosteronism as a> > > > > > > > "masking" condition and were more concerned about what was > > > hiding> > > > > > > > behind it. They were quite surprised when I used the term > > > CYP11B1> > > > > > > > because this is apparently a close relative of Cortisol. > > > That is> > > > > > > > likely why Spironolactone is not right in this condition. > > > When there> > > > > > > > is already an excess cort issue and the action of spiro > > > increases it> > > > > > > > more it becomes a "DOUBLE WHAMMY"! Sorry for the technical > > > jargon,> > > > > > > > I'll work on the complete answer, maybe!> > > > > > > >> > > > > > > > I'll send this now before I get distracted again. I still > > > need to> > > > > > > > figure out where this trip is headed but am honored to > > > have a front> > > > > > > > row seat! We'll need to decide how much you want to know.> > > > > > > >> > > > > > > > ....> > > > > > > >> > > > > > > >> > > > > > >> > > > > >> > > > >> > > > >> > > >> > >> > >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2012 Report Share Posted April 21, 2012 > > > > > > >> > > > > > > > We meant yesterday afternoon when they "released" me. And > > > I will> > > > > > > > share a little here but I actually know little more than > > > you.> > > > > > > >> > > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids." 5 min. > > > summary is> > > > > > > > here….> > > > > > > >> > > > > > > > This is as far as I got before I literally ran out of gas > > > last> > > > > > > > night! I woke up 4 hrs later, went to bed and now it is 5 > > > am and I> > > > > > > > will finish that thought!> > > > > > > >> > > > > > > > From the patent info: 17-Hydroxy-steroids> > > > > > > > Patent 4898694 Issued on February 6, 1990> > > > > > > >> > > > > > > > BACKGROUND OF THE INVENTION> > > > > > > >> > > > > > > > This invention relates to novel steroids and more > > > particularly to> > > > > > > > androsterone derivatives useful as anti-cancer, anti- > > > obesity, anti-> > > > > > > > diabetic, and hypolipidemic agents and useful for combatting> > > > > > > > coronary diseases.> > > > > > > >> > > > > > > > I'm early in understanding but it appears this or a > > > mutation is> > > > > > > > suspected to be in my gene pool./> > > > > > > >> > > > > > > > Okay, 3d try and I will send this today whether or not I > > > get it> > > > > > > > finished! I don't know much more since I spent last night > > > in the ER.> > > > > > > >> > > > > > > > I knew early that they were investigating > > > hyperaldosteronism as a> > > > > > > > "masking" condition and were more concerned about what was > > > hiding> > > > > > > > behind it. They were quite surprised when I used the term > > > CYP11B1> > > > > > > > because this is apparently a close relative of Cortisol. > > > That is> > > > > > > > likely why Spironolactone is not right in this condition. > > > When there> > > > > > > > is already an excess cort issue and the action of spiro > > > increases it> > > > > > > > more it becomes a "DOUBLE WHAMMY"! Sorry for the technical > > > jargon,> > > > > > > > I'll work on the complete answer, maybe!> > > > > > > >> > > > > > > > I'll send this now before I get distracted again. I still > > > need to> > > > > > > > figure out where this trip is headed but am honored to > > > have a front> > > > > > > > row seat! We'll need to decide how much you want to know.> > > > > > > >> > > > > > > > ....> > > > > > > >> > > > > > > >> > > > > > >> > > > > >> > > > >> > > > >> > > >> > >> > >> >> Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2012 Report Share Posted April 21, 2012 I saw the tongue in cheek but many consider taking part in research as becoming a "lab rat". So I always stress that lab rats cannot say no. I recall I sent a letter to the NY Times about this that may have even been published but can't recall or more likely it was not published.Humans always have that option when taking part in a research project-at least since the Geneva Conventions were published after WWII trials.On Apr 21, 2012, at 5:33 PM, wrote: You didn't see my "tongue in cheek"! This is always made very clear and you sign many releases. It's also good to keep focus and young doctors in line. I'm considering a 1-pager "How to be a good lab rat" for them. Hint1: "Feeling like a Rat? Raise the blind instead of opening it. You won't feel like you are looking theough the bars!" > > > > > > > > > > > > > We meant yesterday afternoon when they "released" me. And > > I will > > > > > > > share a little here but I actually know little more than > > you. > > > > > > > > > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids." 5 min. > > summary is > > > > > > > here…. > > > > > > > > > > > > > > This is as far as I got before I literally ran out of gas > > last > > > > > > > night! I woke up 4 hrs later, went to bed and now it is 5 > > am and I > > > > > > > will finish that thought! > > > > > > > > > > > > > > From the patent info: 17-Hydroxy-steroids > > > > > > > Patent 4898694 Issued on February 6, 1990 > > > > > > > > > > > > > > BACKGROUND OF THE INVENTION > > > > > > > > > > > > > > This invention relates to novel steroids and more > > particularly to > > > > > > > androsterone derivatives useful as anti-cancer, anti- > > obesity, anti- > > > > > > > diabetic, and hypolipidemic agents and useful for combatting > > > > > > > coronary diseases. > > > > > > > > > > > > > > I'm early in understanding but it appears this or a > > mutation is > > > > > > > suspected to be in my gene pool./ > > > > > > > > > > > > > > Okay, 3d try and I will send this today whether or not I > > get it > > > > > > > finished! I don't know much more since I spent last night > > in the ER. > > > > > > > > > > > > > > I knew early that they were investigating > > hyperaldosteronism as a > > > > > > > "masking" condition and were more concerned about what was > > hiding > > > > > > > behind it. They were quite surprised when I used the term > > CYP11B1 > > > > > > > because this is apparently a close relative of Cortisol. > > That is > > > > > > > likely why Spironolactone is not right in this condition. > > When there > > > > > > > is already an excess cort issue and the action of spiro > > increases it > > > > > > > more it becomes a "DOUBLE WHAMMY"! Sorry for the technical > > jargon, > > > > > > > I'll work on the complete answer, maybe! > > > > > > > > > > > > > > I'll send this now before I get distracted again. I still > > need to > > > > > > > figure out where this trip is headed but am honored to > > have a front > > > > > > > row seat! We'll need to decide how much you want to know. > > > > > > > > > > > > > > .... > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted April 21, 2012 Report Share Posted April 21, 2012 I saw the tongue in cheek but many consider taking part in research as becoming a "lab rat". So I always stress that lab rats cannot say no. I recall I sent a letter to the NY Times about this that may have even been published but can't recall or more likely it was not published.Humans always have that option when taking part in a research project-at least since the Geneva Conventions were published after WWII trials.On Apr 21, 2012, at 5:33 PM, wrote: You didn't see my "tongue in cheek"! This is always made very clear and you sign many releases. It's also good to keep focus and young doctors in line. I'm considering a 1-pager "How to be a good lab rat" for them. Hint1: "Feeling like a Rat? Raise the blind instead of opening it. You won't feel like you are looking theough the bars!" > > > > > > > > > > > > > We meant yesterday afternoon when they "released" me. And > > I will > > > > > > > share a little here but I actually know little more than > > you. > > > > > > > > > > > > > > The word Dr. M. used is " 17-Hydroxy-steroids." 5 min. > > summary is > > > > > > > here…. > > > > > > > > > > > > > > This is as far as I got before I literally ran out of gas > > last > > > > > > > night! I woke up 4 hrs later, went to bed and now it is 5 > > am and I > > > > > > > will finish that thought! > > > > > > > > > > > > > > From the patent info: 17-Hydroxy-steroids > > > > > > > Patent 4898694 Issued on February 6, 1990 > > > > > > > > > > > > > > BACKGROUND OF THE INVENTION > > > > > > > > > > > > > > This invention relates to novel steroids and more > > particularly to > > > > > > > androsterone derivatives useful as anti-cancer, anti- > > obesity, anti- > > > > > > > diabetic, and hypolipidemic agents and useful for combatting > > > > > > > coronary diseases. > > > > > > > > > > > > > > I'm early in understanding but it appears this or a > > mutation is > > > > > > > suspected to be in my gene pool./ > > > > > > > > > > > > > > Okay, 3d try and I will send this today whether or not I > > get it > > > > > > > finished! I don't know much more since I spent last night > > in the ER. > > > > > > > > > > > > > > I knew early that they were investigating > > hyperaldosteronism as a > > > > > > > "masking" condition and were more concerned about what was > > hiding > > > > > > > behind it. They were quite surprised when I used the term > > CYP11B1 > > > > > > > because this is apparently a close relative of Cortisol. > > That is > > > > > > > likely why Spironolactone is not right in this condition. > > When there > > > > > > > is already an excess cort issue and the action of spiro > > increases it > > > > > > > more it becomes a "DOUBLE WHAMMY"! Sorry for the technical > > jargon, > > > > > > > I'll work on the complete answer, maybe! > > > > > > > > > > > > > > I'll send this now before I get distracted again. I still > > need to > > > > > > > figure out where this trip is headed but am honored to > > have a front > > > > > > > row seat! We'll need to decide how much you want to know. > > > > > > > > > > > > > > .... > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > Quote Link to comment Share on other sites More sharing options...
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