Re: Homocysteine levels in blood

[Guest guest]

No often tested. And no data that I am aware of. Maybe NIH does it. May your pressure be low!CE Grim MS, MDSpecializing in DifficultHypertensionOn Apr 25, 2012, at 12:09, lvasiliu@... wrote:

I have high levels of homocysteine in my blood.

Is this a common finding among PA patients? Does anybody else here have

elevated or high blood homocysteine levels?

Thanks for replying.

tiu

[Guest guest]

Well, well, well tiu - aren't you the smart one! I had never heard of

" homocysteine " so I had to look it up. My guess it might be a " second cousin "

to PA. By that I mean it might not be a direct result of PA but a side effect

of the treatment of PA or some of the effects of PA. Here, look at this:

Source: http://medical-dictionary.thefreedictionary.com/homocysteine

Prevention

Certain drugs are suspected of increasing the level of homocysteine in the

blood. People using these drugs should discuss with their doctor the

advisability of increasing their intake of folic acid, vitamin B6, and vitamin

B12.

These drugs include:

-lipid-lowering drugs such as fenofibrate (Tricor) and bezafibrate (Bezalip)

-metformin (Glucophage), a drug to modify insulin resistance

-anti-epileptic drugs such as phenobarbital, phenytoin (Dilantin), primidone

(Mysoline) and carbamazepine (Tegretol)

-levadopa (Sinemet) for treatment of Parkinson's disease

-methotrexate (Rheumatrex, Trexall) for treatment of cancer, psoriasis,

rheumatoid arthritis, and systemic lupus erythematosus

-androgen treatment

-nitrous oxide ( " laughing gas " ), a mild anesthetic

In my case I use metformin to treat my T2DM which may be caused by PA and I

believe Spironolactone is considered n " androgen treatment " !

I can tell you that NIH did check and in fact have me on a weekly dose of vit.B

and we will recheck in 8 weeks! Kind of makes me wonder if a drug that affects

androgen needlessly is the right drug to treat PA but that is just my opinion!

(The two Endos that I asked at NIH agreed with me, BTW!)

>

> > I have high levels of homocysteine in my blood.

> >

> > Is this a common finding among PA patients? Does anybody else here have

> > elevated or high blood homocysteine levels?

> >

> > Thanks for replying.

> > tiu

> >

> >

>

[Guest guest]

Interesting aspect !

But I was also thinking along the lines of arteries fibrosis in PA and

high blood homocysteine concentrations.

But while searching look what I've found:

" Serum Homocysteine: Relationship with Circulating Levels of Cortisol and

Ascorbate " here:

http://content.karger.com/produktedb/produkte.asp?typ=pdf & file=000158636

" Conclusion: The association between serum concentrations of homocysteine,

cortisol and ascorbate suggests interaction between circulating levels of these

molecules. "

It says that there is a positive correlation between high cortisol and high

homocysteine.

BTW, there is also a connection between homocysteine and depression:

http://ajp.psychiatryonline.org/article.aspx?articleid=98467

>

> Well, well, well tiu - aren't you the smart one! I had never heard of

" homocysteine " so I had to look it up. My guess it might be a " second cousin "

to PA. By that I mean it might not be a direct result of PA but a side effect

of the treatment of PA or some of the effects of PA. Here, look at this:

>

> Source: http://medical-dictionary.thefreedictionary.com/homocysteine

[Guest guest]

Homocysteine levels are problematic for cardiac patients, don't know much more

than that.

>

> I have high levels of homocysteine in my blood.

>

> Is this a common finding among PA patients? Does anybody else here have

> elevated or high blood homocysteine levels?

>

> Thanks for replying.

> tiu

>

[Guest guest]

Well we don't know if they are problematic as there are no studies showing that lower it helps the problem as far as I know. CE Grim MDOn Apr 27, 2012, at 11:56 AM, maggiekat7 wrote: Homocysteine levels are problematic for cardiac patients, don't know much more than that. > > I have high levels of homocysteine in my blood. > > Is this a common finding among PA patients? Does anybody else here have > elevated or high blood homocysteine levels? > > Thanks for replying. > tiu >

[Guest guest]

One of those weird connections to heart disease, that we know increases risk when high, bit when we lower it, doesn't seem to alter the risk - at least not to date. It's new, so research is new, and I guess we need more years under it to get at what it is that drives the risk. I remember reading that Asians, on a hereditary level, seem to have lower homocysteine levels and naturally lower heart disease. Westerners not so luCky, AND our diets are worse on top of it.

Homocysteine levels are problematic for cardiac patients, don't know much more than that.>> I have high levels of homocysteine in my blood.> > Is this a common finding among PA patients? Does anybody else here have> elevated or high blood homocysteine levels?> > Thanks for replying.> tiu>

[Guest guest]

I would use the term interesting rather than weird. And not ready for prime time yet.CE Grim MDOn Apr 29, 2012, at 11:38 PM, Bingham wrote: One of those weird connections to heart disease, that we know increases risk when high, bit when we lower it, doesn't seem to alter the risk - at least not to date. It's new, so research is new, and I guess we need more years under it to get at what it is that drives the risk. I remember reading that Asians, on a hereditary level, seem to have lower homocysteine levels and naturally lower heart disease. Westerners not so luCky, AND our diets are worse on top of it. Homocysteine levels are problematic for cardiac patients, don't know much more than that.>> I have high levels of homocysteine in my blood.> > Is this a common finding among PA patients? Does anybody else here have> elevated or high blood homocysteine levels?> > Thanks for replying.> tiu>