Re: Some comments on spiro and test and a brief history of Aldosterone Stimulating Hormone AKA renin and AII. Maybe more that you wanted to know on Hx of aldo.

[Guest guest]

My PCP, a female doctor in charge of the unit that cares for the female veterans

at the local VA hospital, disagrees with your assessment regarding breasts once

they have developed. My guess is she has dealt with more breast issues in a

month than you have in your lifetime so I have to put my trust in her!

You can continue looking for how spiro antagonizing testosterone in men affects

bones, it probably is a good issue. I believe my post was addressing women and

maybe even postmenopausal!

I still don't understand why one would want to " reduce the risk " or " negate the

issue " when if you do the correct procedure and never introduce the issues in

the first place that would be an issue you wouldn't have to address! Do we just

tell the woman who is 75 and been on Spiro since she was 35 and just broke her

hip, " Oops, maybe I was wrong, maybe Eplerenone (or surgery) wasn't such a bad

option afterall! " IMHO you and your professional friends that treat PA should

be advocating the correct medecine. EVERY PTN should know the choices and risks

so they can make their on choice - they are the one that will have to live with

it or die from it!

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> > > > > > > > > > > > > Since I decided to give Cortisol a rest I got

> > bored

> > > > > > and decided I'd see what " extras " Spironolactone might be

> > doing

> > > > for

> > > > > > the ladies, didn't have to look far!

> > > > > > > > > > > > >

> > > > > > > > > > > > > Hypoactive sexual desire disorder in

> > premenopausal

> > > > > > women: case studies.

> > > > > > > > > > > > >

> > > > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/22314119

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> > > > > > > > > > > > > Do you really need less Androgen?

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[Guest guest]

The "correct" medicine is based on the evidence not on theory. I see no evidence that spiro causes osteopenia etc. The data for high salt intake is very strong. But no trials that lowering salt intake makes Fx less common.The VA should be able to search for this data in a very large data set. Indeed regarding both issues. My guess is I have seen at least as many males with sprio induced breast enlargement/masses (I would estimate 40 but as it is now illegal to keep track of patients information, I do not have details-HIPPA) as she has and they have all gone away when spiro is stopped so yours may be something else. Most were in men who had developed the problem on spiro Rx for PA or difficult HTN. My experience is that every male who takes it long enough gets a problem but if they can lower dose and salt intake it may go away. Of course most of this experience was when I was using 400 mg a day to treat difficult HTN. With DASH it looks like we rarely need to go to that level.Seems like we need to start a file on breast problems on spiro. Men and women. CE Grim MDOn May 4, 2012, at 2:04 PM, wrote: My PCP, a female doctor in charge of the unit that cares for the female veterans at the local VA hospital, disagrees with your assessment regarding breasts once they have developed. My guess is she has dealt with more breast issues in a month than you have in your lifetime so I have to put my trust in her! You can continue looking for how spiro antagonizing testosterone in men affects bones, it probably is a good issue. I believe my post was addressing women and maybe even postmenopausal! I still don't understand why one would want to "reduce the risk" or "negate the issue" when if you do the correct procedure and never introduce the issues in the first place that would be an issue you wouldn't have to address! Do we just tell the woman who is 75 and been on Spiro since she was 35 and just broke her hip, "Oops, maybe I was wrong, maybe Eplerenone (or surgery) wasn't such a bad option afterall!" IMHO you and your professional friends that treat PA should be advocating the correct medecine. EVERY PTN should know the choices and risks so they can make their on choice - they are the one that will have to live with it or die from it! > > > > > > > > > > > > > > > > > > > > > > > > > > Since I decided to give Cortisol a rest I got > > bored > > > > > > and decided I'd see what "extras" Spironolactone might be > > doing > > > > for > > > > > > the ladies, didn't have to look far! > > > > > > > > > > > > > > > > > > > > > > > > > > Hypoactive sexual desire disorder in > > premenopausal > > > > > > women: case studies. > > > > > > > > > > > > > > > > > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/22314119 > > > > > > > > > > > > > > > > > > > > > > > > > > Do you really need less Androgen? > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > > >

[Guest guest]

Here are three studies that I found in less than 15 minutes - Guess I will leave

the care of my boobs in Dr. Webster's hands!

Cytomorphology of male breast lesions: diagnostic pitfalls and clinical

implications.

M, Masood S.

Source

Department of Pathology and Laboratory Medicine, University of Florida College

of Medicine-ville, ville, Florida 32209, USA.

http://www.ncbi.nlm.nih.gov/pubmed/22246937

Breast cancer in males.

http://www.ncbi.nlm.nih.gov/pubmed/21951882

Gynecomastia – evaluation and current treatment options

Ruth E , A Kermott, and M Hassan Murad

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3071351/pdf/tcrm-7-145.pdf

> > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > Since I decided to give Cortisol a rest I

> > got

> > > > bored

> > > > > > > > and decided I'd see what " extras " Spironolactone might be

> > > > doing

> > > > > > for

> > > > > > > > the ladies, didn't have to look far!

> > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > Hypoactive sexual desire disorder in

> > > > premenopausal

> > > > > > > > women: case studies.

> > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > http://www.ncbi.nlm.nih.gov/pubmed/22314119

> > > > > > > > > > > > > > >

> > > > > > > > > > > > > > > Do you really need less Androgen?

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[Guest guest]

Broken bones are likely not caused by excess Aldo or spiro intake.

Most likely a consequence of high Cortisol (aka untreated Cushing's).

[Guest guest]

Remember that adrenal Cushing's will go thru the same evolutionary stages as PA. CE Grim MDOn May 4, 2012, at 5:14 PM, lvasiliu@... wrote: Broken bones are likely not caused by excess Aldo or spiro intake. Most likely a consequence of high Cortisol (aka untreated Cushing's).

[Guest guest]

The study I reported was saying it was a low testosterone issue for older women.

Spiro came into the picture because it is an androgen antgonists which I believe

would reduce circulting testosterone.

>

> Broken bones are likely not caused by excess Aldo or spiro intake.

>

> Most likely a consequence of high Cortisol (aka untreated Cushing's).

>