Spironolactone effect at the CYP11B2/CYP11B1 Gene level in Channel 8

[Guest guest]

Dr. Grim, I am going to explain this one last time so read the whole post.

Spironolactone antagonizes androgen causing a reduction (or elimination, I'm not

sure) at the CYP11B2 gene. This process allows cortisol, which is CYP11B1, the

gene next door to increase. This is all happening on channel 8.

If you are producing excess cortisol for whtever reason you already have excess

cortisol (CYP11B1). If you then apply the effects of spironolactone and

antagonize androgen (CYP11B2) you increase cortisol (CYP11B1) even more (I call

it a " double whammy " !)

This is why NIH thought Spironolactone was the wrong medicine for me. This is

why I would suggest Spironolactone is poor choice for anyone showing signs of

excess cortisol. (Actually this is why I advocate proper testing and treating

appropriately!)

If anyone doesn't know what cortisol does, think " fight or flight " and

depression compounds the problem.

.....