Guest guest Posted February 28, 2009 Report Share Posted February 28, 2009 Some leukemias are suspected or known to have an inherited link (AML, CLL) and some are known (so far) to be acquired diseases like CML. As my father died from Hodgkins and my brother was worried for his infant kid, I asked the question about CML to one of the leading hematologists in Europe, who did work on inherited blood diseases, and his answer was no, as far as we know now, CML is not an inherited disease. He said that a family can have a higher incidence of cancer without an inheritance link, but because they live or have lived close to each other they may have been exposed to the same environment that caused the disease. The fact that a disease is caused by a genetic disorder (BCR-ABL mutation in our case) doesn't mean it is inherited. This mutation has been linked to people working in the chemical industry, nuclear industry, gas stations, military. Some of the first serious epidemiological works on CML came from the followup studies of Hiroshima and Nagasaki. I would imagine drs would be a lot more reluctant letting cml patients have kids if they though cml was transmissible. Marcos On Fri, Feb 27, 2009 at 11:23 PM, Lottie Duthu <lotajam@...> wrote: > I don't know if any of you have heard of inherited leukemia. My sister is > ill and my niece called to ask some questions about leukemia and what kind I > had. She said the doctor mentioned something about inherited leukemia. I > said I never heard of it and the chances of her getting CML, too would be > off the charts. I did look it up and this is what I found: > > http://tinyurl.com/atxkfz > > Blessings, > Lottie > > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 28, 2009 Report Share Posted February 28, 2009 Hi Lottie, I hope your sister is getting better. I'm sorry she is ill. Keep us posted on her health and know that I will say some prayers for her. God bless! Jackie S. From: Lottie Duthu <lotajam@...> Subject: [ ] Inherited Leukemia " CML " < > Date: Saturday, February 28, 2009, 1:23 AM I don't know if any of you have heard of inherited leukemia. My sister is ill and my niece called to ask some questions about leukemia and what kind I had. She said the doctor mentioned something about inherited leukemia. I said I never heard of it and the chances of her getting CML, too would be off the charts. I did look it up and this is what I found: http://tinyurl. com/atxkfz Blessings, Lottie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted February 28, 2009 Report Share Posted February 28, 2009 When I was diagnosed with CML, my first question was if it could be inherited because my grandmother and her daughter which was my fathers sister died of Leukemia. He told me no, that there is no evidence of it being a inherited disease. I will pray for your sister Lottie, and I doubt if she has Leukemia too. Its all such a mystery, and nobody really has the perfect answer. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 Oh Lottie , you and your sister are in my prayers. Eva XXOO From: Lottie Duthu Sent: Saturday, February 28, 2009 2:23 AM CML Subject: [ ] Inherited Leukemia I don't know if any of you have heard of inherited leukemia. My sister is ill and my niece called to ask some questions about leukemia and what kind I had. She said the doctor mentioned something about inherited leukemia. I said I never heard of it and the chances of her getting CML, too would be off the charts. I did look it up and this is what I found: http://tinyurl.com/atxkfz Blessings, Lottie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 Hi Lottie - I'm so sorry to hear about your sister another load to add to your burden. I can't find the article, however in one of our Leukaemia newsletters last year/year before, there was a sorry about CLL and how it was inherited as a few family members had been diagnosed with this and research is being undertaken. Every day I am so thankful that I was dx with CML in this time and era thanks to our Dr Druker as opposed to other blood disorders and cancers. My brother in law has multiple myeloma and is not doing well and is having a mini transplant at the moment and he really hasn't got a good prognosis to live more than 3 years. One of my clients we provide care to stay in their home has CLL and has had this for more than 20 years. He was a Vietnam war veteran. Regards, from Down Under #1149 Zavies Zero Club Dx: 25/07/07 Commenced Glivec 400mg 27/9/07 Changed to Tasigna 800mg 3/8/08 PCRs: 23/01/08 - 13.01 % 14/04/08 - 0.08 % 12/05/08 - 0.02% (Glivec 200mg) 06/08/08 - 0.09 % (commenced Tasigna) 30/09/08 - 0.18 % 19/12/08 - 0.00% From: [mailto: ] On Behalf Of Lottie Duthu Sent: Saturday, 28 February 2009 6:23 PM CML Subject: [ ] Inherited Leukemia I don't know if any of you have heard of inherited leukemia. My sister is ill and my niece called to ask some questions about leukemia and what kind I had. She said the doctor mentioned something about inherited leukemia. I said I never heard of it and the chances of her getting CML, too would be off the charts. I did look it up and this is what I found: http://tinyurl.com/atxkfz Blessings, Lottie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 1, 2009 Report Share Posted March 1, 2009 I don't know about 2nd generation leukemia for parents that have been contaminated by radioactive material. In France there a string of cases in court from people exposed during the French testings in the 50s and 60s and have various kinds of cancer. Until recently you had to prove the cancer couldn't possibly come from something else, what isn't possible, but that changed somewhat and now courts are ruling more often in favor of the plaintiffs. Concerning CML there is an interesting finding in a paper about the followup of Hiroshima and Nagasaki. In the general population CML makes about 15% of leukemia cases. Among the people with leukemia exposed at Hiroshima CML makes 36% of all the leukemia. At Nagasaki the CML contribution is normal. The difference is the composition of the device, uranium for Hiroshima and plutonium for Nagasaki. Here a link to the paper : http://tinyurl.com/cvhbxr Marcos On Sun, Mar 1, 2009 at 9:21 AM, D <lmd23@...> wrote: > Wow, Marcos - that is interesting. My father was involved in the > atomic bomb testing on the south Pacific island of Anewetok (? not > sure of spelling) in the 1950's and also in the atomic testing in > Nevada a few years later. He was in the Air Force. My father has > since passed away (from head and neck cancer, as he was a heavy > smoker), but it makes me wonder about my CML. I wasn't conceived at > the time he had the exposure (I was born in 1965), but I suppose you > never know. > > > > -- Marcos Perreau Guimaraes Suppes Brain Lab Ventura Hall - CSLI Stanford University 220 Panama street Stanford CA 94305-4101 650 614 2305 650 468 9926 (cell) marcospg@... montereyunderwater@... www.stanford.edu/~marcospg/ Quote Link to comment Share on other sites More sharing options...
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