Guest guest Posted March 8, 2009 Report Share Posted March 8, 2009 Aloha Sharon , you mentioned that when you took a vacation from Sprycel because of pleural effusions, it didn't affect your blood counts. The real test is in the marrow, did they do a BMA during that time? I know that the TKI's really do stay in your system for a while and do knock a punch to the phillies, but I am not certain how long we can take a vacation. For the women who went through pregnancy, some switched to Inteferon because it does not cross the blood brain barrier. Some didn't take anything, but their WBC did not say low, their counts escalated if I recall correctly. Once they resumed their treatment, their counts normalized, but I wonder if they were able to recover fully - back to where they were before they stopped. There are still a lot of unanswered questions. I remember distinctly that when I went off Hydrea to get into a trial with INF + HHT, my counts escalated so much in less than the one week wash out period, they had to put me back on Hydrea. I'm quoting you that everyone is different, so I wonder what would happen if I stopped. I had to stop SKI several times because of severe side effects, mainly hives, but I don't recall my counts changing, but there was no mention of the BMA, because there were no other BMA, other than the initial one before I started it. I had time to recover in 3 months for my next BMA. It would be interesting to hear from others who did stop and relapsed. Blessings, Lottie Quote Link to comment Share on other sites More sharing options...
Guest guest Posted March 8, 2009 Report Share Posted March 8, 2009 I have been off all meds since Feb. 19 . I go back to see my onc tomorrow. I am quite nervous as to what may have been going on in Gleevec's absence. Will let you all know . Keep your fingers crossed. I never thought I would say it but I want my Gleevec back. Feeling pretty bad. Eva From: Lottie Duthu Sent: Saturday, March 07, 2009 8:48 PM CML Subject: [ ] Taking a vacation Aloha Sharon , you mentioned that when you took a vacation from Sprycel because of pleural effusions, it didn't affect your blood counts. The real test is in the marrow, did they do a BMA during that time? I know that the TKI's really do stay in your system for a while and do knock a punch to the phillies, but I am not certain how long we can take a vacation. For the women who went through pregnancy, some switched to Inteferon because it does not cross the blood brain barrier. Some didn't take anything, but their WBC did not say low, their counts escalated if I recall correctly. Once they resumed their treatment, their counts normalized, but I wonder if they were able to recover fully - back to where they were before they stopped. There are still a lot of unanswered questions. I remember distinctly that when I went off Hydrea to get into a trial with INF + HHT, my counts escalated so much in less than the one week wash out period, they had to put me back on Hydrea. I'm quoting you that everyone is different, so I wonder what would happen if I stopped. I had to stop SKI several times because of severe side effects, mainly hives, but I don't recall my counts changing, but there was no mention of the BMA, because there were no other BMA, other than the initial one before I started it. I had time to recover in 3 months for my next BMA. It would be interesting to hear from others who did stop and relapsed. Blessings, Lottie Quote Link to comment Share on other sites More sharing options...
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