Re: Alzheimer's - when does it start

[Guest guest]

Wow Lottie- you read my ( tiny) mind.  My father died of Alzheimer's and my

mother has vascular induced  dementia.  I told my sister that I'm not sure if

what I'm experiencing is chemo brain from the Gleevec or early onset of

Alzheimer's but that I was going to do some research.  Thank you for this very

informative article.

From: Lottie Duthu <lotajam@...>

Subject: [ ] Alzheimer's - when does it start

" CML " < >

Date: Thursday, March 19, 2009, 10:25 PM

When and where does Alzheimer's really start? This is a subject no one wants to

talk about, yet we all know someone who is affected by this disease. Remember

the phrase amyloid beta 42 in connection with Alzheimer's, it's a marker, like

Ph+ is a marker for CML.

Researchers at Washington University School of Medicine in St. Louis have linked

a potential indicator of Alzheimer's disease to brain damage in humans with no

signs of mental impairment. Although their cognitive and neurological

assessments were normal, study participants with lower levels of a substance

known as amyloid beta 42 (A-beta 42) in their cerebrospinal fluid (CSF) had

reduced whole brain volumes, suggesting that Alzheimer's changes might already

be damaging their brains. Scientists previously showed that low CSF levels of

A-beta 42 mark the presence of amyloid deposition in the brain, a key diagnostic

marker of the amyloid plaques that characterize Alzheimer's disease. Evidence is

mounting that Alzheimer's harms the brain for many years before physicians and

family members can detect symptoms, and this has led many to conclude that

successful Alzheimer's treatments may only be possible if scientists find ways

to identify pre-symptomatic

sufferers.

The entire article has more information on this subject.

http://www.medicaln ewstoday. com:80/articles/ 141826.php

Blessings,

Lottie