Re: Low Dose

January 10, 2001

This is good at pulling out the mercury that isn't inside cells or

organs. It is great for lead.

Actually it is more economical than high doses. 200 mg pulls out

twice as much as 50 mg, but costs 4 times as much.

Andy

--- In egroups, kenneth kersmanc <kenjoan@r...>

wrote:

> Is it profitable to continue on a low dose of DMSA 50mg.- child

weighs approx. 50 lbs? Is this a waste of time and money? Will we

still be pulling out mercury? Joan

> kenjoan

August 29, 2006

I don't know if this information has reached this list yet, but the NHLBI and Dana Farber are doing clinical studies with low-dose sub-q Rituxan in relapsed patients, and are recruiting patients. The ClinicalTrials.gov links are:

http://www.clinicaltrials.gov/ct/show/NCT000366418?order=1

http://www.clinicaltrials.gov/ct/show/NCT00330252?order=2

Good luck!

Marietta

Marietta Brill cell: 718-938-8712

From: jb50192@...Reply- To: Subject: Low doseDate: Tue, 29 Aug 2006 17:01:33 EDT

All - I'll try to get the subject included in our "special focus" session in LA in October, by Dr. Rai.

November 27, 2006

You didn't post the mgs of your tablet. Are they 50mg? If so, dissolve

1 tablet in 50mg of DISTILLED water, peferrably using a amber glass

bottle. Each mg of the liquid is 1mg of LDN. Shake well before drawing

out each dose, using a baby syringe for measuring.

>

> I can only get a mg dose ftom the pahrmacy, does anyone have ifor on

> crushing a mg tablest, mixing it with water and threfore making mg

> dose, has this been effective for anyone ? Thanks for any replies. K

>

November 27, 2006

Does it matter if it's Distilled water, or will drinking water do. ?

Ken

> >

> > I can only get a mg dose ftom the pahrmacy, does anyone have ifor on

> > crushing a mg tablest, mixing it with water and threfore making mg

> > dose, has this been effective for anyone ? Thanks for any replies. K

> >

>

November 28, 2006

Sorry to be so " thick " but how much is 50 mgs of water ?

> >

> > I can only get a mg dose ftom the pahrmacy, does anyone have ifor on

> > crushing a mg tablest, mixing it with water and threfore making mg

> > dose, has this been effective for anyone ? Thanks for any replies. K

> >

>

November 28, 2006

50 mlOn Nov 27, 2006, at 11:29 PM, kemorson wrote:Sorry to be so "thick" but how much is 50 mgs of water ? > >> > I can only get a mg dose ftom the pahrmacy, does anyone have ifor on > > crushing a mg tablest, mixing it with water and threfore making mg > > dose, has this been effective for anyone ? Thanks for any replies. K> >>

November 28, 2006

Yes, it does matter. DIstilled water is available in most stores and costs about $1.00 a gallon.

50 ml is about two ounces. Get a glass one cup measuring cup with both ounce and milliliter measures on it to measure the water. Use a glass jar or bottle. Recycled four ounce baby food jars are nice.

Syringes to measure out doses are available without a prescription and sometimes free from a pharmacy.

mjh"The Basil Book"http://foxhillfarm.us/FireBasil/

April 24, 2009

Hi , It's been a few years since I have been on Gleevec, but I do

remember this: you must take it with a substantial meal. A little bowl of

cereal won't cut it. Splitting the dose is fine, but take something

especially milk with the meal. And if you don';t feel well, do not lie

down, directly after eating. I hate to see you cut the dose, good luck,

Bobby

On Fri, Apr 24, 2009 at 3:23 PM, Rosen Lum <rrosenlum@...>wrote:

>

> I have been having difficulty with the side effects of Gleevec. My new doc

> asked me to start splitting the dose in half -- 200 mg in the p.m. and 200

> in the a.m. After six weeks, no change. Now he is putting me on a low dose

> of 300 mg. a day. I take 200 at night and 100 in the a.m. Does anyone else

> do this, take less than 400 mg. a day?

>

> in San Francisco

>

> __________________________________________________________

> Rediscover Hotmail®: Get e-mail storage that grows with you.

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2_042009

>

April 24, 2009

Yow! I didn't realize that. So often I just have a glass of water and stuff down

a couple pieces of toast! I thought the whole business of taking it with food

was to prevent nausea ... I had no idea it had anything to do with its efficacy.

From: rmcd1929@...

Date: Fri, 24 Apr 2009 16:22:29 -0400

Subject: Re: [ ] Low dose

Hi , It's been a few years since I have been on Gleevec, but I do

remember this: you must take it with a substantial meal. A little bowl of

cereal won't cut it. Splitting the dose is fine, but take something

especially milk with the meal. And if you don';t feel well, do not lie

down, directly after eating. I hate to see you cut the dose, good luck,

Bobby

On Fri, Apr 24, 2009 at 3:23 PM, Rosen Lum <rrosenlum@...>wrote:

>

> I have been having difficulty with the side effects of Gleevec. My new doc

> asked me to start splitting the dose in half -- 200 mg in the p.m. and 200

> in the a.m. After six weeks, no change. Now he is putting me on a low dose

> of 300 mg. a day. I take 200 at night and 100 in the a.m. Does anyone else

> do this, take less than 400 mg. a day?

>

> in San Francisco

>

> __________________________________________________________

> Rediscover Hotmail®: Get e-mail storage that grows with you.

>

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2_042009

>

April 24, 2009

WHEN DR. DRUKER GAVE ME MY FIRST PILLS IT CAME WITH INSTRUCTIONS (THIS WAS

STILL IN TRIAL), I DON'T KNOW WHY THEY DON;T STILL DO THAT. EATING A GOOD

MEAL, BACON, EGGS, TOAST, MUST HELP ABSORB THE MEDS, AND YOU DON'T GET SICK,

OR AS SICK AS. IF YOU CAN TOLERATE MILK, IT HELPS IF YOU HAVE A SANDWICH

WITH A LARGE GLASS. I DIDN'T EAT ENOUGH BREAKFAST ONE DAY AND HAD TO PULL

OVER INTO SHOPPING MALL AND HEAVE IN FRONT OF A BANK FULL OF PEOPLE!!

GOOD LUCK, IF YOU CHANGE YOUR EATING HABITS YOU MAY TOLERATE THE HIGHER DOSE

AND BE ON THE ROAD TO BETTER LIVING..BOBBY

On Fri, Apr 24, 2009 at 4:31 PM, Rosen Lum <rrosenlum@...>wrote:

>

> Yow! I didn't realize that. So often I just have a glass of water and stuff

> down a couple pieces of toast! I thought the whole business of taking it

> with food was to prevent nausea ... I had no idea it had anything to do with

> its efficacy.

>

> From: rmcd1929@...

> Date: Fri, 24 Apr 2009 16:22:29 -0400

> Subject: Re: [ ] Low dose

>

> Hi , It's been a few years since I have been on Gleevec, but I

> do

>

> remember this: you must take it with a substantial meal. A little bowl of

>

> cereal won't cut it. Splitting the dose is fine, but take something

>

> especially milk with the meal. And if you don';t feel well, do not lie

>

> down, directly after eating. I hate to see you cut the dose, good luck,

>

> Bobby

>

> On Fri, Apr 24, 2009 at 3:23 PM, Rosen Lum <rrosenlum@...

> >wrote:

>

> >

>

> >

>

> >

>

> > I have been having difficulty with the side effects of Gleevec. My new

> doc

>

> > asked me to start splitting the dose in half -- 200 mg in the p.m. and

> 200

>

> > in the a.m. After six weeks, no change. Now he is putting me on a low

> dose

>

> > of 300 mg. a day. I take 200 at night and 100 in the a.m. Does anyone

> else

>

> > do this, take less than 400 mg. a day?

>

> >

>

> > in San Francisco

>

> >

>

> > __________________________________________________________

>

> > Rediscover Hotmail®: Get e-mail storage that grows with you.

>

> >

>

> >

>

http://windowslive.com/RediscoverHotmail?ocid=TXT_TAGLM_WL_HM_Rediscover_Storage\

2_042009

>

> >

>

> >

April 24, 2009

Ha ha ha! I've had those episodes too. But my main beef with Gleevec is the

fatigue. I'm snoozing my life away! I conked out last night around 9:30 p.m.,

woke up at 12 noon, and at 2:40 p.m., I would love nothing right now more than a

nap. Sheesh!

If the 300 mg. doesn't work, he will switch me to Tasigna or Sprycel.

>

> From: rmcd1929@...

> Date: Fri, 24 Apr 2009 16:54:31 -0400

> Subject: Re: [ ] Low dose

>

> WHEN DR. DRUKER GAVE ME MY FIRST PILLS IT CAME WITH INSTRUCTIONS (THIS WAS

> STILL IN TRIAL), I DON'T KNOW WHY THEY DON;T STILL DO THAT. EATING A GOOD

> MEAL, BACON, EGGS, TOAST, MUST HELP ABSORB THE MEDS, AND YOU DON'T GET SICK,

> OR AS SICK AS. IF YOU CAN TOLERATE MILK, IT HELPS IF YOU HAVE A SANDWICH

> WITH A LARGE GLASS. I DIDN'T EAT ENOUGH BREAKFAST ONE DAY AND HAD TO PULL

> OVER INTO SHOPPING MALL AND HEAVE IN FRONT OF A BANK FULL OF PEOPLE!!

> GOOD LUCK, IF YOU CHANGE YOUR EATING HABITS YOU MAY TOLERATE THE HIGHER DOSE

> AND BE ON THE ROAD TO BETTER LIVING..BOBBY

>

> On Fri, Apr 24, 2009 at 4:31 PM, Rosen Lum

<rrosenlum@...>wrote:

>

> >

> > Yow! I didn't realize that. So often I just have a glass of water and stuff

> > down a couple pieces of toast! I thought the whole business of taking it

> > with food was to prevent nausea ... I had no idea it had anything to do with

> > its efficacy.

> >

> > From: rmcd1929@...

> > Date: Fri, 24 Apr 2009 16:22:29 -0400

> > Subject: Re: [ ] Low dose

> >

> > Hi , It's been a few years since I have been on Gleevec, but I

> > do

> >

> > remember this: you must take it with a substantial meal. A little bowl of

> >

> > cereal won't cut it. Splitting the dose is fine, but take something

> >

> > especially milk with the meal. And if you don';t feel well, do not lie

> >

> > down, directly after eating. I hate to see you cut the dose, good luck,

> >

> > Bobby

> >

> > On Fri, Apr 24, 2009 at 3:23 PM, Rosen Lum <rrosenlum@...

> > >wrote:

> >

> > >

> >

> > >

> >

> > >

> >

> > > I have been having difficulty with the side effects of Gleevec. My new

> > doc

> >

> > > asked me to start splitting the dose in half -- 200 mg in the p.m. and

> > 200

> >

> > > in the a.m. After six weeks, no change. Now he is putting me on a low

> > dose

> >

> > > of 300 mg. a day. I take 200 at night and 100 in the a.m. Does anyone

> > else

> >

> > > do this, take less than 400 mg. a day?

> >

> > >

> >

> > > in San Francisco

> >

> > >

> >

> > > __________________________________________________________

> >

> > > Rediscover Hotmail®: Get e-mail storage that grows with you.

> >

> > >

> >

> > >

> >

http://windowslive.com/RediscoverHotmail?ocid=TXT_TAGLM_WL_HM_Rediscover_Storage\

2_042009

> >

> > >

> >

> > >

April 25, 2009

Hi : Bobby is right. If I just eat a very light meal, and then take my

Gleevec 400MG. I would get nausea. I started to eat a good breakfast, and then

my glass of water with the Gleevec. The substantial amount of food really

works.

Some people like to take their medication with dinner because then in most cases

they know they are eating more. I guess its according to your schedule.

Our dinner time is never at the same time, therefore, I chose to do my

Gleevec with Breakfast. This way I know I took my pill, and I am done for the

day. All my other medications are once a day also, so everything gets taken in

the morning.

Hope some of this helped you. Maybe if you took 200mg. with breakfast, and

then 200mg with Dinner. Just an idea.

April 25, 2009

Hi ,

I found early on when I was on Glivec that I felt hell on earth if taken

only with a light meal. I always had to eat it in the middle of a

substantial meal which for me was in the evening. So unlike now with Tasigna

where you have to take it on a fasting regime.

What are your PCR's? If going on a smaller dose, they need to be monitored

more closely to ensure it is not a sub optimal dose.

Regards,

from Down Under

From: [mailto: ] On Behalf Of

Rosen Lum

Sent: Saturday, 25 April 2009 5:24 AM

Subject: [ ] Low dose

I have been having difficulty with the side effects of Gleevec. My new doc

asked me to start splitting the dose in half -- 200 mg in the p.m. and 200

in the a.m. After six weeks, no change. Now he is putting me on a low dose

of 300 mg. a day. I take 200 at night and 100 in the a.m. Does anyone else

do this, take less than 400 mg. a day?

in San Francisco

__________________________________________________________

Rediscover HotmailR: Get e-mail storage that grows with you.

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rage2_042009

April 25, 2009

- Were you taking 1 /400 mg or 4/ 100 mg? You didn't say what kind of

side effects. I found I could tolerate the 400 mg pill better than 4/100 mgs.

I'll let those with more knowledge weigh in on this but it is my understanding

that less than 400 mg is a sub therapeutic dose. I started on that dose

because my red blood cells were low and he was afraid about how low they might

go when I started on Gleevec. But I told him I wanted to go to 400 ASAP and as

soon as my levels stabilized I went to 400 and have remained there since April

2007. I'm not trying to second guess him but - How many CML patients does your

doc have?

> From: Rosen Lum <rrosenlum@...>

> Subject: [ ] Low dose

>

> Date: Friday, April 24, 2009, 12:23 PM

> I have been having difficulty with the side effects of

> Gleevec. My new doc asked me to start splitting the dose in

> half -- 200 mg in the p.m. and 200 in the a.m. After six

> weeks, no change. Now he is putting me on a low dose of 300

> mg. a day. I take 200 at night and 100 in the a.m. Does

> anyone else do this, take less than 400 mg. a day?

>

> in San Francisco

>

> _________________________________________________________________

> Rediscover Hotmail®: Get e-mail storage that grows with

> you.

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2_042009

>

April 25, 2009

Since '05 I took one 400 mg pill at bedtime each day. I started having terrible

side effects several months ago (!) -- sleeping 16 and more hours a day and

suffering terrible, but very predictable, bouts of depression that would show up

at around 11 a.m. and disappear like clockwork around 6 or so. My old hem/onc

told me to tough it out, I was lucky to be alive and for my labs to look so

good, but then I switched docs. The new guy (his name is Anand Druva) had me

first try splitting the dose evenly, one at night and one in the a.m. That was a

dud. So now I'm on the 300 mg. dose (200 mg in the p.m. and 100 in the a.m.). I

have to confess I am nervous about it.

From: chimera46@...

Date: Fri, 24 Apr 2009 22:39:47 -0700