Guest guest Posted May 23, 2009 Report Share Posted May 23, 2009 Hi everyone. I don't post too often, was diagnosed about a year ago and have been doing very well on Gleevec until about 5 weeks ago when my liver enzymes became slightly/moderatly elevated. Reduced dose to 300 mg and began monitoring weekly and every week enzymes went up. After having been off Gleevec completely for 1 week enzymes still rising (ALT 350, AST 280). Because enzymes still rose while off Gleevec, my onc thinks it might not be Gleevec related. Has anyone else had an experience like this where enzymes still rose while off drug? Maybe it takes longer than a week before they stop rising? I'm going to a liver specialist next week and will probably have a biopsy. Staying off Gleevec for now. Thanks for your help! Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 23, 2009 Report Share Posted May 23, 2009 Hi Kathy, If you look through the archives, you'll see that there have been many discussions about this subject. It can take weeks, even months sometimes, for the liver enzymes to get back to normal. This has me wondering how much your doctor knows about Gleevec related hepatoxicity. The elevated enzymes are most likely related to the Gleevec but you should still get a hepatitis test to rule that out. Tracey > > Hi everyone. I don't post too often, was diagnosed about a year ago and have been doing very well on Gleevec until about 5 weeks ago when my liver enzymes became slightly/moderatly elevated. Reduced dose to 300 mg and began monitoring weekly and every week enzymes went up. After having been off Gleevec completely for 1 week enzymes still rising (ALT 350, AST 280). Because enzymes still rose while off Gleevec, my onc thinks it might not be Gleevec related. Has anyone else had an experience like this where enzymes still rose while off drug? Maybe it takes longer than a week before they stop rising? I'm going to a liver specialist next week and will probably have a biopsy. Staying off Gleevec for now. Thanks for your help! > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted May 26, 2009 Report Share Posted May 26, 2009 Thanks Tracey- It turns out that I have tested positive for Epstein Barr/Mononucleosis (at 48 yrs old!). So my Doc thinks that is what's causing the elevating liver enzymes and I'm starting back on Gleevec today after 2 weeks off. Hopefully, this is all it is..I have been extra tired with on and off sore throat. Also, by doc admits he doesn't know much about CML or Gleevec. But he does contact other doctors about me, last week he spoke to Dr. Kantarjian from MC , who told him I might need to switch to Sprycel. Kathy -- In , " Tracey " <traceyincanada@...> wrote: > > Hi Kathy, > > If you look through the archives, you'll see that there have been many discussions about this subject. It can take weeks, even months sometimes, for the liver enzymes to get back to normal. This has me wondering how much your doctor knows about Gleevec related hepatoxicity. The elevated enzymes are most likely related to the Gleevec but you should still get a hepatitis test to rule that out. > > Tracey > > > > > > > Hi everyone. I don't post too often, was diagnosed about a year ago and have been doing very well on Gleevec until about 5 weeks ago when my liver enzymes became slightly/moderatly elevated. Reduced dose to 300 mg and began monitoring weekly and every week enzymes went up. After having been off Gleevec completely for 1 week enzymes still rising (ALT 350, AST 280). Because enzymes still rose while off Gleevec, my onc thinks it might not be Gleevec related. Has anyone else had an experience like this where enzymes still rose while off drug? Maybe it takes longer than a week before they stop rising? I'm going to a liver specialist next week and will probably have a biopsy. Staying off Gleevec for now. Thanks for your help! > > > Quote Link to comment Share on other sites More sharing options...
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