Guest guest Posted June 11, 2009 Report Share Posted June 11, 2009 Dear group, in my daily newspaper yesterday there was an article on the front page saying Lab in Barharbor Me.[ a physician and researcher] may have identified a cure for the most commonform of human leukemia, chronic myeloid leukemia.the genecalled Alox5 allows leukemia producingstem cells to develop and proliferatesays Li [the physician and researcher] says.he says when you block the genes function you,re going to be leukemia free.mice treated with a combination of a drug called Zileuton,,and gleevic If you remove the gene in the mouse you don,t see leukemia develope.He said it must now be studied in human clinical trials. The results of his study has been published in the current issue of the journal National Genetics. Wow , possible, maybe, a fellow cml,er in Bucksport Maine Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 11, 2009 Report Share Posted June 11, 2009 I can't help but raise an eyebrow when I read " may have identified a cure for the most common form of human leukemia, chronic myeloid leukemia " . CML is far from the most common form of leukemia, in fact, it's one of the rarest forms. If they can get that wrong, I can't help but wonder what else they got wrong. Tracey > > Dear group, in my daily newspaper yesterday there was an article on the front page saying Lab in Barharbor Me.[ a physician and researcher] may have identified a cure for the most commonform of human leukemia, chronic myeloid leukemia.the genecalled Alox5 allows leukemia producingstem cells to develop and proliferatesays Li [the physician and researcher] says.he says when you block the genes function you,re going to be leukemia free.mice treated with a combination of a drug called Zileuton,,and gleevic If you remove the gene in the mouse you don,t see leukemia develope.He said it must now be studied in human clinical trials. The results of his study has been published in the current issue of the journal National Genetics. Wow , possible, maybe, a fellow cml,er in Bucksport Maine > Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 11, 2009 Report Share Posted June 11, 2009 > > > > Dear group, in my daily newspaper yesterday there was an article on the front page saying Lab in Barharbor Me.[ a physician and researcher] may have identified a cure for the most commonform of human leukemia, chronic myeloid leukemia.the genecalled Alox5 allows leukemia producingstem cells to develop and proliferatesays Li [the physician and researcher] says.he says when you block the genes function you,re going to be leukemia free.mice treated with a combination of a drug called Zileuton,,and gleevic If you remove the gene in the mouse you don,t see leukemia develope.He said it must now be studied in human clinical trials. The results of his study has been published in the current issue of the journal National Genetics. Wow , possible, maybe, a fellow cml,er in Bucksport Maine > > > Hi. It's a long way medically from mouse to man! Zileuton is a drug originally developed to treat asthma. However it mostly fell out of use due to liver toxicity-a problem when combined with Gleevec, etc. Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 11, 2009 Report Share Posted June 11, 2009 Yes in the general population CML is the rarest of the 4 main leukemias, but do you expect press releases to be accurate nowadays ? . The group mentioned in the article has a paper in Nature Genetics (not National Genetics like below...) which is a legitimate scientific journal. The claims are a little more prudent than in the press release. But they seem to have identified a new pathway to target CML LSC (Leukemia Stem Cells) that are not well targeted by gleevec or the other approved drugs (they target more the differentiated cells). From there to clinical trials and a drug there is a long way but it doesn't hurt to have drs still looking for new treatments. Marcos. On Thu, Jun 11, 2009 at 10:19 AM, Tracey<traceyincanada@...> wrote: > > > I can't help but raise an eyebrow when I read " may have identified a cure > for the most common form of human leukemia, chronic myeloid leukemia " . CML > is far from the most common form of leukemia, in fact, it's one of the > rarest forms. If they can get that wrong, I can't help but wonder what else > they got wrong. > > Tracey > > >> >> Dear group, in my daily newspaper yesterday there was an article on the >> front page saying Lab in Barharbor Me.[ a physician and researcher] >> may have identified a cure for the most commonform of human leukemia, >> chronic myeloid leukemia.the genecalled Alox5 allows leukemia producingstem >> cells to develop and proliferatesays Li [the physician and researcher] >> says.he says when you block the genes function you,re going to be leukemia >> free.mice treated with a combination of a drug called Zileuton,,and gleevic >> If you remove the gene in the mouse you don,t see leukemia develope.He said >> it must now be studied in human clinical trials. The results of his study >> has been published in the current issue of the journal National Genetics. >> Wow , possible, maybe, a fellow cml,er in Bucksport Maine >> > > -- Marcos Perreau Guimaraes Suppes Brain Lab Ventura Hall - CSLI Stanford University 220 Panama street Stanford CA 94305-4101 650 614 2305 650 468 9926 (cell) marcospg@... montereyunderwater@... www.stanford.edu/~marcospg/ Quote Link to comment Share on other sites More sharing options...
Guest guest Posted June 12, 2009 Report Share Posted June 12, 2009 As exciting as this sounds, it is a long long way from lab mice testing to human trials. Zavie Zavie (age 70) 67 Shoreham Avenue Ottawa, Canada, K2G 3X3 dxd AUG/99 INF OCT/99 to FEB/00, CHF No meds FEB/00 to JAN/01 Gleevec since MAR/27/01 (400 mg) CCR SEP/01. #102 in Zero Club 2.8 log reduction Sep/05 3.0 log reduction Jan/06 2.9 log reduction Feb/07 3.6 log reduction Apr/08 3.6 log reduction Sep/08 3.7 log reduction Jan/09 3.8 log reduction May/09 e-mail: zmiller@... Tel: 613-726-1117 Fax: 613-482-4801 Cell: 613-282-0204 ID: zaviem YM: zaviemiller Skype: Zavie _____ From: [mailto: ] On Behalf Of sopranograndma Sent: June 11, 2009 11:47 AM Subject: [ ] cure possible Dear group, in my daily newspaper yesterday there was an article on the front page saying Lab in Barharbor Me.[ a physician and researcher] may have identified a cure for the most commonform of human leukemia, chronic myeloid leukemia.the genecalled Alox5 allows leukemia producingstem cells to develop and proliferatesays Li [the physician and researcher] says.he says when you block the genes function you,re going to be leukemia free.mice treated with a combination of a drug called Zileuton,,and gleevic If you remove the gene in the mouse you don,t see leukemia develope.He said it must now be studied in human clinical trials. The results of his study has been published in the current issue of the journal National Genetics. Wow , possible, maybe, a fellow cml,er in Bucksport Maine Quote Link to comment Share on other sites More sharing options...
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