Re: Sustained Molecular Remission

[Guest guest]

Hi Matt,

That's the STIM (STop IMatinib) trial. The Dr I see in Paris is part

of it (I do not qualify). I think the trial is still going on and more

patients have been enrolled. To be in the trial you needed to be PCRU

for two years, so it concerns a very limited fraction of cml patients

(~15% reach PCRU), and an even smaller fraction of them may be cured

(off medication and no relapse). The best hope for the rest of us

would be new drugs or combination of drugs improving this rate.

Marcos.

On Tue, Apr 21, 2009 at 5:27 PM, <mtmaynor@...> wrote:

>

>

>

> Zavie (or anyone for that matter):

>

> My wife ran across this journal in a blood cancer

> discussion board, but I could not find any other

> reference to it:

>

> In Blood Sep 2006, the French CML Working Group report a study

> showing that 50% of 12 CML patients (who achieved sustained PCRU of

> at least 2 years on imatinib) have sustained their molecular

> remission at median 18 months of follow-up after discontinuing the

> drug.

>

> All the experts I have spoken with say that CML comes back,

> even if you do reach PCRU once you get off medication.

>

> Anybody heard of this test or these results?

>

> With the warmest regards,

>

> Matt

> CML of Florida

> Dx January of 2005

> Gleevec March of 2005

> Tasigna November of 2007

> Number 1078 in the Esteemed Zavie Zero Club

> **************Access 350+ FREE radio stations anytime from anywhere on the

> web. Get the Radio Toolbar!

> (http://toolbar.aol.com/aolradio/download.html?ncid=emlcntusdown00000003)

>

>

[Guest guest]

Wow wish I could be in that trial.

I have been on tasigna for 14 month and pcru for 11 month.

St

Sent via BlackBerry by AT & T

Re: [ ] Sustained Molecular Remission

Hi Matt,

That's the STIM (STop IMatinib) trial. The Dr I see in Paris is part

of it (I do not qualify). I think the trial is still going on and more

patients have been enrolled. To be in the trial you needed to be PCRU

for two years, so it concerns a very limited fraction of cml patients

(~15% reach PCRU), and an even smaller fraction of them may be cured

(off medication and no relapse). The best hope for the rest of us

would be new drugs or combination of drugs improving this rate.

Marcos.

On Tue, Apr 21, 2009 at 5:27 PM, <mtmaynor@...> wrote:

>

>

>

> Zavie (or anyone for that matter):

>

> My wife ran across this journal in a blood cancer

> discussion board, but I could not find any other

> reference to it:

>

> In Blood Sep 2006, the French CML Working Group report a study

> showing that 50% of 12 CML patients (who achieved sustained PCRU of

> at least 2 years on imatinib) have sustained their molecular

> remission at median 18 months of follow-up after discontinuing the

> drug.

>

> All the experts I have spoken with say that CML comes back,

> even if you do reach PCRU once you get off medication.

>

> Anybody heard of this test or these results?

>

> With the warmest regards,

>

> Matt

> CML of Florida

> Dx January of 2005

> Gleevec March of 2005

> Tasigna November of 2007

> Number 1078 in the Esteemed Zavie Zero Club

> **************Access 350+ FREE radio stations anytime from anywhere on the

> web. Get the Radio Toolbar!

> (http://toolbar.aol.com/aolradio/download.html?ncid=emlcntusdown00000003)

>

>

[Guest guest]

For those who want to read more here's a link to the article reporting

the results

http://tinyurl.com/curjte

If you can't get it either ask Blood journal for access and mention

you are a patient, or send an email to me offline.

Marcos.

On Tue, Apr 21, 2009 at 6:52 PM, <onthewtr@...> wrote:

>

>

> Wow wish I could be in that trial.

> I have been on tasigna for 14 month and pcru for 11 month.

> St

> Sent via BlackBerry by AT & T

>

> Re: [ ] Sustained Molecular Remission

>

>

> Hi Matt,

> That's the STIM (STop IMatinib) trial. The Dr I see in Paris is part

> of it (I do not qualify). I think the trial is still going on and more

> patients have been enrolled. To be in the trial you needed to be PCRU

> for two years, so it concerns a very limited fraction of cml patients

> (~15% reach PCRU), and an even smaller fraction of them may be cured

> (off medication and no relapse). The best hope for the rest of us

> would be new drugs or combination of drugs improving this rate.

> Marcos.

>

> On Tue, Apr 21, 2009 at 5:27 PM, <mtmaynor@...> wrote:

>>

>>

>>

>> Zavie (or anyone for that matter):

>>

>> My wife ran across this journal in a blood cancer

>> discussion board, but I could not find any other

>> reference to it:

>>

>> In Blood Sep 2006, the French CML Working Group report a study

>> showing that 50% of 12 CML patients (who achieved sustained PCRU of

>> at least 2 years on imatinib) have sustained their molecular

>> remission at median 18 months of follow-up after discontinuing the

>> drug.

>>

>> All the experts I have spoken with say that CML comes back,

>> even if you do reach PCRU once you get off medication.

>>

>> Anybody heard of this test or these results?

>>

>> With the warmest regards,

>>

>> Matt

>> CML of Florida

>> Dx January of 2005

>> Gleevec March of 2005

>> Tasigna November of 2007

>> Number 1078 in the Esteemed Zavie Zero Club

>> **************Access 350+ FREE radio stations anytime from anywhere on the

>> web. Get the Radio Toolbar!

>> (http://toolbar.aol.com/aolradio/download.html?ncid=emlcntusdown00000003)

>>

>>

[Guest guest]

Hi Matt,

This is an ongoing study and what you read is true. What you didn't read was

that all the patients that maintained their PCRU after stopping Gleevec were

in Interferon prior to taking Gleevec. Those who didn't take Interferon

first relapsed.

Zavie

Zavie (age 70)

67 Shoreham Avenue

Ottawa, Canada, K2G 3X3

dxd AUG/99

INF OCT/99 to FEB/00, CHF

No meds FEB/00 to JAN/01

Gleevec since MAR/27/01 (400 mg)

CCR SEP/01. #102 in Zero Club

2.8 log reduction Sep/05

3.0 log reduction Jan/06

2.9 log reduction Feb/07

3.6 log reduction Apr/08

3.6 log reduction Sep/08

e-mail: zmiller@...

Tel: 613-726-1117

Tel: 561-429-3309 in Florida

Fax: 309-296-0807

Cell: 613-282-0204

ID: zaviem

YM: zaviemiller

Skype: Zavie

_____

From: [mailto: ] On Behalf Of

mtmaynor@...

Sent: April-21-09 8:27 PM

Subject: [ ] Sustained Molecular Remission

Zavie (or anyone for that matter):

My wife ran across this journal in a blood cancer

discussion board, but I could not find any other

reference to it:

In Blood Sep 2006, the French CML Working Group report a study

showing that 50% of 12 CML patients (who achieved sustained PCRU of

at least 2 years on imatinib) have sustained their molecular

remission at median 18 months of follow-up after discontinuing the

drug.

All the experts I have spoken with say that CML comes back,

even if you do reach PCRU once you get off medication.

Anybody heard of this test or these results?

With the warmest regards,

Matt

CML of Florida

Dx January of 2005

Gleevec March of 2005

Tasigna November of 2007

Number 1078 in the Esteemed Zavie Zero Club

**************Access 350+ FREE radio stations anytime from anywhere on the

web. Get the Radio Toolbar!

(http://toolbar.

<http://toolbar.aol.com/aolradio/download.html?ncid=emlcntusdown00000003>

aol.com/aolradio/download.html?ncid=emlcntusdown00000003)

[Guest guest]

Yes, and that's probably one of the motivations of the gleevec/peg

interferon trials going on now. Although the report with the dozen of

patients was a pilot study (which started the STIM trial) and with the

constraint of 2 years of PCRU at the time of this study it was going

to have lots of people initially on gleevec, and it biases the

results. The authors claimed in a 2008 meeting the trend of sustained

remission off drug toward patients previously on inteferon is not

statistically significant. For a more recent report with more patients

see http://tinyurl.com/d5feyj. The problem the STIM study is probably

still facing is the scarcity of patients to enroll, but that may

improve as the bulk of cml patients increase and more reach PCRU with

the 2nd generation drugs. This may be a big battleground between

pharmaceuticals and health insurance systems (private or public) as

one can imagine the economic implications.

Marcos.

On Wed, Apr 22, 2009 at 7:35 AM, Zavie <zmiller@...> wrote:

>

>

> Hi Matt,

>

> This is an ongoing study and what you read is true. What you didn't read was

> that all the patients that maintained their PCRU after stopping Gleevec were

> in Interferon prior to taking Gleevec. Those who didn't take Interferon

> first relapsed.

>

> Zavie

>

>

> Zavie (age 70)

> 67 Shoreham Avenue

> Ottawa, Canada, K2G 3X3

> dxd AUG/99

> INF OCT/99 to FEB/00, CHF

> No meds FEB/00 to JAN/01

> Gleevec since MAR/27/01 (400 mg)

> CCR SEP/01. #102 in Zero Club

> 2.8 log reduction Sep/05

> 3.0 log reduction Jan/06

> 2.9 log reduction Feb/07

> 3.6 log reduction Apr/08

> 3.6 log reduction Sep/08

> e-mail: zmiller@...

> Tel: 613-726-1117

> Tel: 561-429-3309 in Florida

> Fax: 309-296-0807

> Cell: 613-282-0204

> ID: zaviem

> YM: zaviemiller

> Skype: Zavie

>

> _____

>

> From: [mailto: ] On Behalf Of

> mtmaynor@...

> Sent: April-21-09 8:27 PM

>

> Subject: [ ] Sustained Molecular Remission

>

> Zavie (or anyone for that matter):

>

> My wife ran across this journal in a blood cancer

> discussion board, but I could not find any other

> reference to it:

>

> In Blood Sep 2006, the French CML Working Group report a study

> showing that 50% of 12 CML patients (who achieved sustained PCRU of

> at least 2 years on imatinib) have sustained their molecular

> remission at median 18 months of follow-up after discontinuing the

> drug.

>

> All the experts I have spoken with say that CML comes back,

> even if you do reach PCRU once you get off medication.

>

> Anybody heard of this test or these results?

>

> With the warmest regards,

>

> Matt

> CML of Florida

> Dx January of 2005

> Gleevec March of 2005

> Tasigna November of 2007

> Number 1078 in the Esteemed Zavie Zero Club

> **************Access 350+ FREE radio stations anytime from anywhere on the

> web. Get the Radio Toolbar!

> (http://toolbar.

> <http://toolbar.aol.com/aolradio/download.html?ncid=emlcntusdown00000003>

> aol.com/aolradio/download.html?ncid=emlcntusdown00000003)

>

>

[Guest guest]

Marcos:

Thank you for the information. Go Stanford!

With the warmest regards,

Matt

CML of Florida

Dx January of 2005

Gleevec March of 2005

Tasigna November of 2007

Number 1078 in the Esteemed Zavie Zero Club

In a message dated 4/21/2009 10:46:15 P.M. Eastern Daylight Time,

montereyunderwater@... writes:

For those who want to read more here's a link to the article reporting

the results

_http://tinyurl.http://tin_ (http://tinyurl.com/curjte)

If you can't get it either ask Blood journal for access and mention

you are a patient, or send an email to me offline.

Marcos.

On Tue, Apr 21, 2009 at 6:52 PM, <_onthewtr@..._

(mailto:onthewtr@...) > wrote:

>

>

> Wow wish I could be in that trial.

> I have been on tasigna for 14 month and pcru for 11 month.

> St

> Sent via BlackBerry by AT & T

>

> -----Original Message-----

> From: Marcos Perreau Guimaraes <_montereyunderwater@montereyu_

(mailto:montereyunderwater@...) >

>

> Date: Tue, 21 Apr 2009 18:16:04

> <_@..._ (mailto: ) >

> Subject: Re: [ ] Sustained Molecular Remission

>

>

> Hi Matt,

> That's the STIM (STop IMatinib) trial. The Dr I see in Paris is part

> of it (I do not qualify). I think the trial is still going on and more

> patients have been enrolled. To be in the trial you needed to be PCRU

> for two years, so it concerns a very limited fraction of cml patients

> (~15% reach PCRU), and an even smaller fraction of them may be cured

> (off medication and no relapse). The best hope for the rest of us

> would be new drugs or combination of drugs improving this rate.

> Marcos.

>

> On Tue, Apr 21, 2009 at 5:27 PM, <_mtmaynor@..._

(mailto:mtmaynor@...) > wrote:

>>

>>

>>

>> Zavie (or anyone for that matter):

>>

>> My wife ran across this journal in a blood cancer

>> discussion board, but I could not find any other

>> reference to it:

>>

>> In Blood Sep 2006, the French CML Working Group report a study

>> showing that 50% of 12 CML patients (who achieved sustained PCRU of

>> at least 2 years on imatinib) have sustained their molecular

>> remission at median 18 months of follow-up after discontinuing the

>> drug.

>>

>> All the experts I have spoken with say that CML comes back,

>> even if you do reach PCRU once you get off medication.

>>

>> Anybody heard of this test or these results?

>>

>> With the warmest regards,

>>

>> Matt

>> CML of Florida

>> Dx January of 2005

>> Gleevec March of 2005

>> Tasigna November of 2007

>> Number 1078 in the Esteemed Zavie Zero Club

>> ************ ************<WBR>**Access 350+ FREE radio stations anytime

fr

>> web. Get the Radio Toolbar!

>>

(_http://toolbar.http://toolbar.http://toohttp://toohttp://toolbar.http_

(http://toolbar.aol.com/aolradio/download.html?ncid=emlcntusdown00000003) )

>>

>> [Non-text portions of this message have been removed]

>>

>>

>

>

>

> --

> Marcos Perreau Guimaraes

> Suppes Brain Lab

> Ventura Hall - CSLI

> Stanford University

> 220 Panama street

> Stanford CA 94305-4101

> 650 614 2305

> 650 468 9926 (cell)

> _marcospg@..._ (mailto:marcospg@...)

> _montereyunderwater@montereyu_ (mailto:montereyunderwater@...)

> www.stanford. www.stanf

>

>

> [Non-text portions of this message have been removed]

>

>

--

Marcos Perreau Guimaraes

Suppes Brain Lab

Ventura Hall - CSLI

Stanford University

220 Panama street

Stanford CA 94305-4101

650 614 2305

650 468 9926 (cell)

_marcospg@..._ (mailto:marcospg@...)

_montereyunderwater@montereyu_ (mailto:montereyunderwater@...)

www.stanford.www.stanford.

With the warmest regards,

Matt

CML of Florida

Dx January of 2005

Gleevec March of 2005

Tasigna November of 2007

Number 1078 in the Esteemed Zavie Zero Club

**************Access 350+ FREE radio stations anytime from anywhere on the

web. Get the Radio Toolbar!

(http://toolbar.aol.com/aolradio/download.html?ncid=emlcntusdown00000003)