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Dr. Druker Award

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Dear Barb,

I found the article through a link at the web site you sent. I quote the

article from it:

http://www.epo.org/about-us/press/backgrounders/inventors2009.html

Chronic myelogenous leukaemia (CML) was long-considered one of the deadliest

forms of cancer, affecting both adults and children. But now with Glivec, a

cancer fighting drug, CML has become much more treatable thanks to American

oncologist Druker and Swiss medicinal chemist Jürg Zimmermann.

In 1960, researchers discovered that CML was caused by an abnormally short

chromosome and 13 years later it emerged that this was the result of chromosome

swapping: therein lay the key to a cure. In 1990, researchers began looking for

inhibitors of the fusion protein " BCR-ABL " , which causes the overproduction of

white blood cells in the body. Scientists working for Swiss-based pharmaceutical

company Novartis developed a compound designed to reduce BCR-ABL, and Jürg

Zimmermann and his team set about improving the compound. In 1994, Novartis

teamed up with oncologist Druker and set about refining the inhibitor.

Today, the compound now known as Glivec is hailed as a wonder drug. Follow-up

data shows that Glivec therapy helps stabilise the blood count of 98% of

patients.

Perhaps someone would come up with a novel idea for letting him know we

appreciate the giant recognition if his dedication and work.

FYI,

Lottie

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